Molecular shape land size of hyaluronic acid and chondroitinsulphuric acid

• THE hyaluronic acid, which was first isolated from vitreous humor1, and later has been found in, for example, synovial fluid2 and navel cord tissue3 gives highly viscous solutions and is often precipitated as fibres. Its molecules have therefore been assumed to have a chain structure. The Chondroitinsulphuric acid gives less viscous solutions and is precipitated at most in small fibres of little coherence. Levene and La Forge4 tentatively expressed its structural formula as a tetrasaccharide, a view which seemed to receive support from von Fürth and Bruno5, who by the aid of Northrop’s diffusion method obtained a molecular weight of about 975.

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