| 1. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 2. |
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| 3. |
- van Rheenen, W, et al.
(författare)
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Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
- 2021
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 53:12, s. 1636-
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Tidskriftsartikel (refereegranskat)abstract
- Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons.
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| 5. |
- Bernardi, G., et al.
(författare)
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The Future Circular Collider : a Summary for the US 2021 Snowmass Process
- 2022
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In this white paper for the 2021 Snowmass process, we give a description of the proposed Future Circular Collider (FCC) project and its physics program. The paper summarizes and updates the discussion submitted to the European Strategy on Particle Physics. After construction of an approximately 90 km tunnel, an electron-positron collider based on established technologies allows world-record instantaneous luminosities at center-of-mass energies from the Z resonance up to tt thresholds, enabling a rich set of fundamental measurements including Higgs couplings determinations at the sub percent level, precision tests of the weak and strong forces, and searches for new particles, including dark matter, both directly and via virtual corrections or mixing. Among other possibilities, the FCC-ee will be able to (i) indirectly discover new particles coupling to the Higgs and/or electroweak bosons up to scales around 7 and 50 TeV, respectively; (ii) perform competitive SUSY tests at the loop level in regions not accessible at the LHC; (iii) study heavy-flavor and tau physics in ultra-rare decays beyond the LHC reach, and (iv) achieve the best potential in direct collider searches for dark matter, sterile neutrinos, and axion-like particles with masses up to around 90 GeV. The tunnel can then be reused for a proton-proton collider, establishing record center-of-mass collision energy, allowing unprecedented reach for direct searches for new particles up to the around 50 TeV scale, and a diverse program of measurements of the Standard Model and Higgs boson, including a precision measurement of the Higgs self-coupling, and conclusively testing weakly-interacting massive particle scenarios of thermal relic dark matter.
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| 6. |
- Gini, L., et al.
(författare)
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Part-Load Behaviour And Control Philosophy Of A Recuperated Supercritical Co2Cycle
- 2022
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Ingår i: Proceedings of the ASME Turbo Expo. - : American Society of Mechanical Engineers (ASME).
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Konferensbidrag (refereegranskat)abstract
- High efficiency, flexibility and competitive capital costs make supercritical CO2 (sCO2) systems a promising technology for renewable power generation in a low carbon energy scenario. Recently, innovative supercritical systems have been studied in the literature and proposed by DOE-NETL (STEP project) and a few projects in the EU Horizon 2020 program aiming to demonstrate supercritical CO2 Brayton power plants, promising superior techno-economic features than steam cycles particularly at high temperatures. The H2020 SOLARSCO2OL project1, which started in 2020, is building the first European MW-scale sCO2 demonstration plant and has been specifically tailored for Concentrating Solar Power (CSP) applications. This paper presents the first offdesign analysis of such a demonstrator, which is based on a simply recuperated sCO2 cycle. The part-load analysis ranged from 50% of nominal up to a 105% peak load, discussing the impact on compressor and turbine operating conditions. The whole system dynamic model has been developed in TRANSEO MATLAB® environment. Full operational envelop has been determined considering cycle main constraints, such as maximum turbine inlet temperature and minimum pressure at compressor inlet. The off-design performance analysis highlights the most relevant relationships among the main part-load regulating parameters, namely mass flow rate, total mass in the loop, and available heat source. The results show specific features of different control approaches, discussing the pros and cons of each solution, considering also its upscale towards commercial applications. In particular, the analysis shows that at 51% of load an efficiency decrease of 20% is expected.
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| 7. |
- Guédez, Rafael, et al.
(författare)
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Design Of A 2 Mw Molten Salt Driven Supercritical Co2 Cycle And Turbomachinery For The Solarsco2Ol Demonstration Project
- 2022
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Ingår i: Proceedings of the ASME Turbo Expo. - : ASME International.
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Konferensbidrag (refereegranskat)abstract
- Supercritical CO2 (sCO2) power cycles have been identified as technology enablers for increasing the cost-competitiveness of Concentrating Solar Power (CSP) plants. Compared to steam cycles, sCO2 cycles have the advantage of allowing higher inlet turbine temperatures, while also deploying turbomachinery that can be a ten-fold more compact. Ongoing research in CSP focuses mainly in developing new receiver and storage concepts able to withstand such required higher temperatures, alongside new heat exchangers that enable coupling to a sCO2 cycle. Meanwhile, advancements in sCO2 turbomachinery have taken place in research projects aimed at investigating the technical feasibility of the cycle, including the optimized design of its individual components and new cycle configurations. Among these, only few focus in demonstrating a full-integrated system, including cycle control and dynamics, and only two worldwide have started plans for MW-scale pilots, none of them in Europe. The EU-funded SOLARSCO2OL project aims at demonstrating a first-of-a-k ind 2 MW gross simple-recuperated sCO2 Brayton cycle driven by heat provided by molten salt s similar to those deployed in commercial CSP plants, which are able to operate at temperatures of up to 580°C. This paper introduces the project objectives and implementation plan, to then focus primarily on the results derived from the first year in specific relation to the conceptual design of each of 2 MW scale power cycle and its k ey components, including also the proposed integration and operational regimes, expected thermod ynamic performance at nominal point, and up-scaling considerations.
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