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- Bjork, E, et al.
(författare)
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Diazoxide treatment at onset preserves residual insulin secretion in adults with autoimmune diabetes
- 1996
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 45:10, s. 1427-1430
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Tidskriftsartikel (refereegranskat)abstract
- Twenty islet cell antibody (ICA)-positive patients, aged 19–38 years, with IDDM were randomized at onset to treatment with either diazoxide, a K+ channel opener that inhibits the release of insulin, or placebo for 3 months, in addition to multiple insulin injection therapy. The patients who were given diazoxide displayed higher residual insulin secretion than the placebo group after 1 year (basal C-peptide level, 0.40 ± 0.04 vs. 0.25 ± 0.04 [mean ± SE] nmol/l; P < 0.021) and at an 18-month follow-up (0.37 ± 0.06 vs. 0.20 ± 0.01 nmol/l, P < 0.033). Metabolic control did not differ between the two groups. During the course of the study, no differences in islet cell or GAD autoantibodies were detected between the two groups. The results of this study warrant further trials to explore the potential of inducing target cell rest in order to halt the loss of insulin-producing cells during the early course of the disease.
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- Bjork, T, et al.
(författare)
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Physical vapour deposition duplex coatings for aluminium extrusion dies
- 1999
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Ingår i: WEAR. - : ELSEVIER SCIENCE SA. - 0043-1648. ; 229:2, s. 1123-1130
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Duplex coatings [plasma nitriding followed by physical vapour deposition (PVD) coating] have been given a lot of interest as surface treatment for forming and cutting tools in recent years. The advantage, as compared to conventional PVD coating, is a high
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| 10. |
- Hansson, H, et al.
(författare)
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Verification of a pencil beam based treatment planning system: output factors for open photon beams shaped with MLC or blocks
- 1999
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Ingår i: Physics in Medicine and Biology. - 1361-6560. ; 44:9, s. 201-207
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Tidskriftsartikel (refereegranskat)abstract
- The accuracy of monitor unit calculations from a pencil beam based, three-dimensional treatment planning system (3D TPS) has been evaluated for open irregularly shaped photon fields. The dose per monitor unit was measured in water and in air for x-ray beam qualities from 6 to 15 MV. The fields were shaped either with a multileaf collimator (MLC) or with customized alloy blocks. Calculations from the 3D TPS were compared with measurements. The agreement between calculated and measured dose per monitor unit depended on field size and the amount of blocking and was within 3% for the MLC-shaped fields. The deviation could be traced to limitations in head scatter modelling for the MLC. For fields shaped with alloy blocks, the dose per monitor unit was calculated to be within 1.6% of measured values for all fields studied. The measured and calculated relative phantom scatter for fields with the same equivalent field size were identical for MLC and alloy shaped fields. These results indicate that the accuracy in the TPS calculations for open irregular fields, shaped with MLC or blocks, is satisfactory for clinical situations.
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