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| 2. |
- Svanberg, Sune, et al.
(författare)
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Applications of terawatt lasers
- 1994
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Ingår i: LASER SPECTROSCOPY - XITH INTERNATIONAL CONFERENCE. - : AIP. - 1551-7616 .- 0094-243X. - 1563962624 ; :290, s. 264-269
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Konferensbidrag (refereegranskat)
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| 3. |
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| 4. |
- Al-Ramadan, Afkar, et al.
(författare)
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Analysis of radiation effects in two irradiated tumor spheroid models
- 2018
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Ingår i: Oncology Letters. - : Spandidos Publications. - 1792-1074 .- 1792-1082. ; 15:3, s. 3008-3016
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Tidskriftsartikel (refereegranskat)abstract
- Multicellular spheroids have proven suitable as three-dimensional in vivo-like models of non-vascularized micrometastases. Unlike monolayer-based models, spheroids mirror the cellular milieu and the pathophysiological gradients inside tumor nodules. However, there is limited knowledge of the radiation effects at the molecular level in spheroids of human origin. The present study is a presentation of selected cell biological processes that may easily be analyzed with methods available at routine pathology laboratories. Using gamma irradiated pancreatic neuroendocrine BON1 and colonic adenocarcinoma HCT116 spheroids as model systems, the present study assessed the radiobiological response in these models. Spheroid growth after irradiation was followed over time and molecular responses were subsequently assessed with immunohistochemistry (IHC) staining for descriptive analyses and semi-automatic grading of apoptosis, G(2)-phase and senescence in thin sections of the spheroids. Growth studies demonstrated the BON1 spheroids were slower growing and less sensitive to radiation compared with the HCT116 spheroids. IHC staining for G2-phase was primarily observed in the outer viable P-cell layers of the spheroids, with the 6 Gy irradiated HCT116 spheroids demonstrating a very clear increase in staining intensity compared with unirradiated spheroids. Apoptosis staining results indicated increased apoptosis with increasing radiation doses. No clear association between senescence and radiation exposure in the spheroids were observed. The present results demonstrate the feasibility of the use of multicellular spheroids of human origin in combination with IHC analyses to unravel radiobiological responses at a molecular level. The present findings inspire further investigations, including other relevant IHC-detectable molecular processes in time-and radiation dose-dependent settings.
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| 5. |
- Albertsson, Martin, et al.
(författare)
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Calculated fission-fragment mass yields and average total kinetic energies of heavy and superheavy nuclei
- 2020
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 56:2
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Tidskriftsartikel (refereegranskat)abstract
- Fission-fragment mass and total-kinetic-energy (TKE) distributions following fission of even-even nuclides in the region 74 ≤ Z≤ 126 and 92 ≤ N≤ 230 , comprising 896 nuclides have been calculated using the Brownian shape-motion method. The emphasis is the region of superheavy nuclei. To show compatibility with earlier results the calculations are extended to include earlier studied regions. An island of asymmetric fission is obtained in the superheavy region, 106 ≤ Z≤ 114 and 162 ≤ N≤ 176 , where the heavy fragment is found to be close to 208Pb and the light fragment adjusts accordingly. Most experimentally observed α-decay chains of superheavy nuclei with Z> 113 terminate by spontaneous fission in our predicted region of asymmetric fission. In these cases, the pronounced large asymmetry is accompanied by a low TKE value compatible with measurements.
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| 7. |
- Andersson, Karl, 1972-
(författare)
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Characterization of Biomolecular Interactions Using a Multivariate Approach
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis presents a novel bioinformatic methodology denoted the bio-chemometric approach. The methodology is designed for generation of detailed descriptions and predictions of biomolecular interactions. It is based on multivariate analysis of the sensitivity of a biomolecular interaction to multiple minor changes in the experimental conditions. In this work, either the chemical environment where the interaction takes place, or the molecular structure of one of the interacting molecules, was varied. The sensitivity of the interaction to the performed variations was presented as a vector called the sensitivity fingerprint. The bio-chemometric approach was tested on several biomolecular interactions. Useful descriptions of the interactions were obtained by measuring binding kinetics for each interaction in 12-20 different buffers and correlating buffer composition to binding kinetics. The obtained chemical sensitivity fingerprints were reproducible, significantly different and showed a weak correlation to binding site properties for the tested interactions. The results indicate that the fingerprints contained useful information about the binding site. The predictive ability of the bio-chemometric approach was tested on two different biomolecular interactions where one of the binding partners was slightly modified into multiple analogues by amino acid exchanges. In one example, interactions of 18 peptide analogues with an antibody gave data that could be used for accurate prediction of the dissociation rates of novel analogues. Reliable predictions of binding kinetics and affinity were also obtained for single domain camel antibody analogues binding to a protein antigen. By using the three-dimensional structure of camel antibodies and data obtained using the bio-chemometric approach, even the importance of non-exchanged amino acids for the binding could be estimated. The bio-chemometric approach can potentially improve the development of peptides and proteins for therapeutic and diagnostic use. It is suggested to be valid for general use in biochemistry.
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| 8. |
- Andersson, Lise-Lotte, et al.
(författare)
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Extensive Gamma-ray Spectroscopy of Normally and Superdeformed Structures in 61Cu
- 2008
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 36:3, s. 251-278
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Tidskriftsartikel (refereegranskat)abstract
- A largely extended experimental knowledge of the Cu-61(29)32 nucleus has been obtained from three experiments. Excited states in Cu-61 were produced via the fusion-evaporation reaction Si-28(Ar-36, 3p)Cu-61. In addition to the Ge array GAMMASPHERE, neutron and charged-particle detectors placed around the target position were used for high-performance particle spectroscopy. The constructed level scheme includes more than 160 energy levels and 320 gamma-ray transitions belonging to both normally deformed as well as superdeformed rotational structures. The multipolarities have been determined for the gamma-ray transitions and as a result spin-parity assignments are given for nearly all energy levels. Experimental results in the normally deformed region are compared with predictions from large-scale shell model calculations. The collective structures are compared with results from cranked Nilsson-Strutinsky calculations. The results reveal the need to modify the standard Nilsson parameters in the mass A similar to 60 region.
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| 10. |
- Anna, Carlsson, et al.
(författare)
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Olyckor och skador hos rollatoranvändare i trafikmiljön. Oral presentation vid Transportforum i Linköping den 8-9 januari 2020.
- 2020
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Ingår i: Transportforum i Linköping, konferens.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Bakgrund Rollatorn uppfanns 1978 i Västerås av Aina Wifalk. Idag är Sverige det rullator-tätaste landet i världen och det förskrivs ca 60 000 rullatorer per år. SCB beräknade 2007 att 240 000 personer använde rollator, bland dem ingick var tredje person över 80 år. 2014 fanns 499 000 personer i åldern 80+ i Sverige, år 2030 beräknas antalet ha ökat till 826 000 och 2060 så många som 1 210 000. Om kvoten rollatoranvändare kvarstår kan vi alltså år 2060 räkna med 720 000 rollatoranvändare, bara i åldersgruppen 80+. Användare av rollatorer tillhör gruppen oskyddade trafikanter, men är sällan uppmärksammade i trafiksäkerhetskontexten. Syftet med studien är därför att analysera olycks- och skadedata, som inrapporterats till den nationella databasen STRADA, där användare av rollatorer varit involverade. Resultatet av studien ger värdefull kunskap om risker och hinder som användare av rollator utsätts för i olika typer av trafikmiljöer. Syftet är också att studien ska kunna bidra till att förbättra rörligheten för denna grupp på lång sikt. Metod Studien baseras på olycks- och skadedata från totalt 2 020 rapporterade olyckor med rollator. Inledningsvis undersöktes om antalet rollatorolyckor ökar, minskar eller är konstant över tid. Därefter registrerades varje olycka som antingen ”singel” (N=1 668) eller ”kollision” (N=352). Resultat och slutsats Studien visade på en nästan fördubbling av antalet rollatorrelaterade olyckor i Sverige under perioden 2007–2016. Vidare var ca tre gånger fler kvinnor än män involverade i olyckor med rollator. I en majoritet av singelolyckorna slog användaren i marken. Många av singelolyckorna orsakades av nivåskillnader/kanter, ojämnt underlag eller snubbling. Bilar, lastbilar eller bussar var inblandade i 79% av kollisionerna. Dessa inträffade ofta vid parkeringsplatser, korsningar eller vägsträcka; i många av fallen blev rollatoranvändaren påbackad.
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