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Träfflista för sökning "WFRF:(Chang S. H.) srt2:(1996-1999)"

Sökning: WFRF:(Chang S. H.) > (1996-1999)

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  • Chang, W, et al. (författare)
  • Parathyroid Ca(2+)-conducting currents are modulated by muscarinic receptor agonists and antagonists.
  • 1997
  • Ingår i: The American journal of physiology. - 0002-9513. ; 273:5 Pt 1
  • Tidskriftsartikel (refereegranskat)abstract
    • Parathyroid cells express Ca(2+)-conducting cation currents, which are activated by raising the extracellular Ca2+ concentration ([Ca2+]o) and blocked by dihydropyridines. We found that acetylcholine (ACh) inhibited these currents in a reversible, dose-dependent manner (50% inhibitory concentration approximately equal to 10(-8) M). The inhibitory effects could be mimicked by the agonist (+)-muscarine. The effects of ACh were blunted by the antagonist atropine and reversed by removing ATP from the pipette solution (+)-Muscarine enhanced the adenosine 3',5'-cyclic monophosphate (cAMP) production by 30% but had no effect on inositol phosphate accumulation in parathyroid cells. Oligonucleotide primers, based on sequences of known muscarinic receptors (M1-M5), were used in reverse transcriptase-polymerase chain reaction (RT-PCR) to amplify receptor cDNA from parathyroid poly (A)+ RNA. RT-PCR products displayed > 90% nucleotide sequence identity to human M2- and M4-receptor cDNAs. Expression of M2-receptor protein was further confirmed by immunoblotting and immunocytochemistry. Thus parathyroid cells express muscarinic receptors of M2 and possibly M4 subtypes. These receptors may couple to dihydropyridine-sensitive, cation-selective currents through the activation of adenylate cyclase and ATP-dependent pathways in these cells.
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  • Herron, J.N., Durtschi, J.D., Wang, H-K, Janatova, V., Chang, I-N, Huang, S-C, Caldwell, K.D., and Christensen, D.A. (författare)
  • Orientation and Activity of Immobilized Antibodies
  • 1998
  • Ingår i: M. Malmsten, (ed.), Biopolymers at Interfaces. - : Dekker, NY. ; , s. 221-280
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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