Ultrasome : efficient aberration caller for copy number studies of ultra-high resolution

• Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size.  Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10 000 times faster than standard methods with preserved analytic accuracy.

Ämnesord

NATURVETENSKAP  -- Biologi -- Bioinformatik och systembiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)

Nyckelord

DNA

accuracy

article

chromosome aberration

computer program

controlled study

DNA microarray

gene number

human

human cell

information processing

intermethod comparison

mathematical analysis

priority journal

receiver operating characteristic

Ultrasome

Algorithms

Chromosome Aberrations

Computational Biology

Gene Dosage

Gene Expression Profiling

Oligonucleotide Array Sequence Analysis

Polymorphism

Single Nucleotide

Bioinformatics

Bioinformatik

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)