| 1. |
- Gustafson, Yngve, et al.
(författare)
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Depression in old age in Austria, Ireland, Portugal and Sweden
- 2013
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Ingår i: European Geriatric Medicine. - : Elsevier BV. - 1878-7649 .- 1878-7657. ; 4:3, s. 202-208
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Tidskriftsartikel (refereegranskat)abstract
- Depression is the third leading cause of disease burden worldwide and the most frequent psychiatric disorder in the older adult population. Depression in old age is disabling, both psychosocially and physically, decreases quality of life and increases mortality. This paper explores the epidemiology, screening, diagnosis and management of depression in old age in four European countries in an attempt to gain a better understanding of the issues contributing to the variability in clinical practice. The prevalence of depression in community dwelling older individuals is high, but studies in the oldest population and in specific settings (like nursing homes) are few. Depression may go undiagnosed, and wide screening programs for early identification of this disease are uncommon. Depression screening is consistently included in comprehensive geriatric assessment, and most geriatricians appear to be confident in its diagnosis and management. Old age psychiatry is still largely underdeveloped, except for Ireland. Primary care physicians start treatment of depression in most countries, referring only complex cases for specialised care. SSRIs seem to be the first line treatment, but choice of antidepressants is widely variable in different countries. Availability of non-pharmacological therapies is still low, and only highly skilled centres use a multifaceted approach to depression care. Attitudes towards depression and mental illness are still mostly negative, which may hinder identification and management of this highly prevalent geriatric problem.
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| 2. |
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| 3. |
- Dabrowski, A. E., et al.
(författare)
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Measuring the bunch frequency multiplication at CTF3
- 2010
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Konferensbidrag (refereegranskat)abstract
- The CTF3 facility is being built and commissioned by an international collaboration in order to test the feasibility of the proposed CLIC drive beam generation scheme. Central to this scheme is the use of RF deflectors to inject bunches into a Delay Loop and a Combiner Ring, in order to transform the initial bunch spacing of 1.5 GHz from the linac to a final bunch spacing of 12 GHz. The optimization procedure relies on several steps. The active length of each ring is carefully adjusted to within a few millimeters accuracy using a two‐period undulator. The transverse optics of the machine must be set-up in a way so as to ensure the beam isochronicity. Diagnostics based on optical streak cameras and RF power measurements have been designed to measure the longitudinal behaviour of the beam during the combination. This paper presents their performance and highlights recent measurements.
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| 4. |
- Dabrowski, A. E., et al.
(författare)
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Measuring the bunch frequency multiplication at the 3rd CLIC Test Facility
- 2012
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Ingår i: Journal of Instrumentation. - 1748-0221 .- 1748-0221. ; 7, s. P01005-
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Tidskriftsartikel (refereegranskat)abstract
- The CLIC Test Facility 3 (CTF3) is being built and commissioned by an international collaboration to test the feasibility of the proposed Compact Linear Collider (CLIC) drive beam generation scheme. Central to this scheme is the use of RF deflectors to inject bunches into a delay loop and a combiner ring, in order to transform the initial bunch frequency of 1.5 GHz from the linac to a final bunch frequency of 12 GHz. To do so, the machine's transverse optics must be tuned to ensure beam isochronicity and each ring's length can finally be adjusted with wiggler magnets to a sub millimeter path length accuracy. Diagnostics based on optical streak camera and RF power measurements, in particular frequency bands, have been designed to measure the longitudinal behaviour of the beam during the combination. This paper presents the diagnostics and recent commissioning measurements.
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| 5. |
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| 6. |
- Minekus, M., et al.
(författare)
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A standardised static in vitro digestion method suitable for food - an international consensus
- 2014
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Ingår i: Food and Function. - : Royal Society of Chemistry (RSC). - 2042-6496 .- 2042-650X. ; 5:6, s. 1113-1124
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Tidskriftsartikel (refereegranskat)abstract
- Simulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of macronutrients (e. g. lipids, proteins and carbohydrates) are used for screening and building new hypotheses. Various digestion models have been proposed, often impeding the possibility to compare results across research teams. For example, a large variety of enzymes from different sources such as of porcine, rabbit or human origin have been used, differing in their activity and characterization. Differences in pH, mineral type, ionic strength and digestion time, which alter enzyme activity and other phenomena, may also considerably alter results. Other parameters such as the presence of phospholipids, individual enzymes such as gastric lipase and digestive emulsifiers vs. their mixtures (e. g. pancreatin and bile salts), and the ratio of food bolus to digestive fluids, have also been discussed at length. In the present consensus paper, within the COST Infogest network, we propose a general standardised and practical static digestion method based on physiologically relevant conditions that can be applied for various endpoints, which may be amended to accommodate further specific requirements. A frameset of parameters including the oral, gastric and small intestinal digestion are outlined and their relevance discussed in relation to available in vivo data and enzymes. This consensus paper will give a detailed protocol and a line-by-line, guidance, recommendations and justifications but also limitation of the proposed model. This harmonised static, in vitro digestion method for food should aid the production of more comparable data in the future.
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| 7. |
- Olvegård, Maja, et al.
(författare)
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High intensity profile monitor for time resolved spectrometry at the CLIC Test Facility 3
- 2012
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 683, s. 29-39
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Tidskriftsartikel (refereegranskat)abstract
- The power source of the Compact Linear Collider (CLIC) relies on the generation and deceleration of a high-intensity electron drive beam. In order to provide the best radio-frequency (RF) to beam-energy transfer efficiency, the electron beam is accelerated using fully loaded RF cavities, which leads to strong beam loading effects resulting in a high-energy transient. The stability of the RF power produced by the drive beam depends on the stability of the drive beam energy and energy spread along the pulse. The control and the monitoring of the time evolution of the beam energy distribution are therefore crucial for the accelerator performance. For this purpose segmented beam dumps, which are simple and robust devices, have been designed and installed at the CLIC Test Facility 3 (CTF3). These devices are located at the end of spectrometer lines and provide horizontal beam profiles with a time resolution better than 10 ns. The segmented dumps are composed of parallel, vertical, metallic plates, and are based on the same principle as a Faraday cup: the impinging beam current is read by a fast acquisition channel. Both FLUKA and Geant4 simulations were performed to define the optimum detector geometry for beam energies ranging from 5 MeV to 150 MeV. This paper presents a detailed description of the different steps of the design: the optimization of the detector spatial resolution, the minimization of the thermal load and the long-term damage resulting from high radiation doses. Four segmented dumps are currently used in the CTF3 complex. Their measured performance and limitations are presented in this paper. Typical beam spectra as measured in the CTF3 linac are also presented along with a description of the RF manipulations needed for tuning the beam energy spectrum.
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