Tyck till om SwePub Sök
här!
Sökning: WFRF:(Grontved Anders)
> (2010) >
Genetic susceptibil...
Genetic susceptibility to obesity and related traits in childhood and adolescence influence of loci identified by genome-wide association studies
-
- den Hoed, Marcel, 1980- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Hematologi och immunologi,den Hoed
-
- Ekelund, Ulf (författare)
- Örebro universitet,Hälsoakademin,Epidemiol Unit, Inst Metab Sci, Medical Research Council (MRC), Cambridge, England
-
- Brage, Soren (författare)
- Epidemiol Unit, Inst Metab Sci, Medical Research Council (MRC), Cambridge, England
-
visa fler...
-
- Grontved, Anders (författare)
- Inst Sport Sci & Clin Biomech, Univ So Denmark, Odense, Denmark
-
- Zhao, Jing Hua (författare)
- Epidemiol Unit, Inst Metab Sci, Medical Research Council (MRC), Cambridge, England
-
- Sharp, Stephen J. (författare)
- Epidemiol Unit, Inst Metab Sci, Medical Research Council (MRC), Cambridge, England
-
- Ong, Ken K. (författare)
- Epidemiol Unit, Inst Metab Sci, Medical Research Council (MRC), Cambridge, England
-
- Wareham, Nicholas J. (författare)
- Epidemiol Unit, Inst Metab Sci, Medical Research Council (MRC), Cambridge, England
-
- Loos, Ruth J. F. (författare)
- Epidemiol Unit, Inst Metab Sci, Medical Research Council (MRC), Cambridge, England
-
visa färre...
-
(creator_code:org_t)
- 2010-08-19
- 2010
- Engelska.
-
Ingår i: Diabetes. - Alexandria, USA : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 59:11, s. 2980-2988
- Relaterad länk:
-
https://diabetes.dia...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.2...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: Large-scale genome-wide association (GWA) studies have thus far identified 16 loci incontrovertibly associated with obesity-related traits in adults. We examined associations of variants in these loci with anthropometric traits in children and adolescents.Research design and methods: Seventeen variants representing 16 obesity susceptibility loci were genotyped in 1,252 children (mean +/- SD age 9.7 +/- 0.4 years) and 790 adolescents (15.5 +/- 0.5 years) from the European Youth Heart Study (EYHS). We tested for association of individual variants and a genetic predisposition score (GPS-17), calculated by summing the number of effect alleles, with anthropometric traits. For 13 variants, summary statistics for associations with BMI were meta-analyzed with previously reported data (N-total = 13,071 children and adolescents). Results: In EYHS, 15 variants showed associations or trends with anthropometric traits that were directionally consistent with earlier reports in adults. The meta-analysis showed directionally consistent associations with BMI for all 13 variants, of which 9 were significant (0.033-0.098 SD/allele; P < 0.05). The near-TMEM18 variant had the strongest effect (0.098 SD/allele P = 8.5 x 10(-11)). Effect sizes for BMI tended to be more pronounced in children and adolescents than reported earlier in adults for variants in or near SEC16B, TMEM18, and KCTD15, (0.028-0.035 SD/allele higher) and less pronounced for rs925946 in BDNF (0.028 SD/allele lower). Each additional effect allele in the GPS-17 was associated with an increase of 0.034 SD in BMI (P = 3.6 x 10(-5)), 0.039 SD, in sum of skinfolds (P = 1.7 x 10(-7)), and 0.022 SD in waist circumference (P = 1.7 X 10(-4)), which is comparable with reported results in adults (0.039 SD/allele for BMI and 0.033 SD/allele for waist circumference).Conclusions: Most obesity susceptibility loci identified by GWA studies in adults are already associated with anthropometric traits in children/adolescents. Whereas the association of some variants may differ with age, the cumulative effect size is similar. Diabetes 59:2980-2988, 2010
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Nyckelord
- Sports
- Idrott
- Sports Science
- Idrottsvetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Diabetes
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas