| 1. |
- Andersson, Jennie, 1986, et al.
(författare)
-
On the Selection of Optimal Propeller Diameter for a 120m Cargo Vessel
- 2018
-
Ingår i: SNAME 15th Propeller and Shafting Symposium, PSS 2018.
-
Konferensbidrag (refereegranskat)abstract
- In the preliminary design of a propulsion unit the selection of propeller diameter is most commonly based on open water tests of systematic propeller series. The optimum diameter obtained from the propeller series data is however not considered to be representative for the operating conditions behind the ship, instead a slightly smaller diameter is often selected. We have used computational fluid dynamics (CFD) to study a 120m cargo vessel with an integrated rudder bulb-propeller hubcap system and a 4-bladed propeller series, to increase our understanding of the hydrodynamic effects influencing the optimum. The results indicate that a 3-4 % smaller diameter is optimal in behind conditions in relation to open water conditions at the same scale factor. The reason is that smaller, higher loaded propellers perform better together with a rudder system. This requires that the gain in transverse kinetic energy losses thanks to the rudder overcomes the increase in viscous losses in the complete propulsion system
|
|
| 2. |
- Dreij, Kristian, et al.
(författare)
-
Cancer Risk Assessment of Airborne PAHs Based on in Vitro Mixture Potency Factors
- 2017
-
Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 51:15, s. 8805-8814
-
Tidskriftsartikel (refereegranskat)abstract
- Complex mixtures of polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants associated with adverse human health effects including cancer. However, the risk of exposure to mixtures is difficult to estimate, and risk assessment by whole mixture potency evaluations has been suggested. To facilitate this, reliable in vitro based testing systems are necessary. Here, we investigated if activation of DNA damage signaling in vitro could be an endpoint for developing whole mixture potency factors (MPFs) for airborne PAHs. Activation of DNA damage signaling was assessed by phosphorylation of Chid and H2AX using Western blotting. To validate the in vitro approach, potency factors were determined for seven individual PAHs which were in very good agreement with established potency factors based on cancer data in vivo. Applying the method using Stockholm air PAH samples indicated MPFs with orders of magnitude higher carcinogenic potency than predicted by established in vivo-based potency factors. Applying the MPFs in cancer risk assessment suggested that 45.4 (6% of all) cancer cases per year in Stockholm are due to airborne PAHs. Applying established models resulted in <1 cancer case per year, which is far from expected levels. We conclude that our in vitro based approach for establishing MPFs could be a novel method to assess whole mixture samples of airborne PAHs to improve health risk assessment.
|
|
| 3. |
- Eslamdoost, Arash, 1982, et al.
(författare)
-
Analysis of Propeller-Hull Interaction Phenomena on a Self-Propelled Axisymmetric Body
- 2017
-
Ingår i: 5th Int. Symposium on Marine Propulsor.
-
Konferensbidrag (refereegranskat)abstract
- The Reynolds Transport theorem for energy is used to study propeller-hull interaction effects by analyzing different components of energy flux through a control volume around a self-propelled vessel. These components are the axial kinetic energy, the transversal kinetic energy, the turbulent kinetic energy, the internal energy and the pressure work. This energy balance approach is here used to study the influence of propeller diameter on the propulsive power. To this end, propellers of different diameters have been studied in behind condition. In order to keep the incoming wake into the propellers as simple as possible, an axi-symmetric hull shape is employed. The energy fluxes are calculated employing a RANS approach to solve the momentum transport and continuity equations together with the energy equation (the heat transfer equation in fluid). The latter equation is solved to compute the internal energy. The results show a minor difference on interaction effects. However, analyzing the energy flux components and their contribution to the total energy provides an extra tool for better understanding of the interaction effects.
|
|
| 4. |
- Gustafsson, Jennie, et al.
(författare)
-
The right to stay put : Resistance and organizing in the wake of changing housing policies in Sweden
- 2019
-
Ingår i: Radical Housing Journal. - 2632-2870. ; 1:2, s. 191-200
-
Tidskriftsartikel (refereegranskat)abstract
- Tenants in Sweden increasingly face rising rents and displacement due to decades of ongoing housing deregulation. In this text, we explore different manifestations of these injustices, and reflect upon consequences and responses as they crystalize locally. By visiting the three cities of Stockholm, Malmö and Uppsala, we highlight three different examples of how tenants respond and formulate protests vis-a-vis privatization through tenure conversion (Stockholm), gentrification spurred by private rental actors (Malmö) and battles over green space and displacement in the rental housing stock (Uppsala). These vignettes exemplify how policy changes play out in different local settings and illustrate how resistance manifests itself on the ground.
|
|
| 5. |
- Gustafsson, Jennie, et al.
(författare)
-
The right to stay put: Resistance and organizing in the wake of changing housing policies in Sweden
- 2019
-
Ingår i: Radical Housing Journal. - : Radical Housing Journal. - 2632-2870. ; 1:2, s. 191-200
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Tenants in Sweden increasingly face rising rents and displacement due to decades of ongoing housing deregulation. In this text, we explore different manifestations of these injustices, and reflect upon consequences and responses as they crystalize locally. By visiting the three cities of Stockholm, Malmö and Uppsala, we highlight three different examples of how tenants respond and formulate protests vis-a-vis privatization through tenure conversion (Stockholm), gentrification spurred by private rental actors (Malmö) and battles over green space and displacement in the rental housing stock (Uppsala). These vignettes exemplify how policy changes play out in different local settings and illustrate how resistance manifests itself on the ground.
|
|
| 6. |
- Locke, Adam E, et al.
(författare)
-
Genetic studies of body mass index yield new insights for obesity biology.
- 2015
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
-
Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
|
|
| 7. |
- Shungin, Dmitry, et al.
(författare)
-
New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
-
Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
|
|
