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Träfflista för sökning "WFRF:(Gustavsson I) srt2:(2000-2004)"

Sökning: WFRF:(Gustavsson I) > (2000-2004)

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  • Gruber, A, et al. (författare)
  • A phase I/II study of the MDR modulator Valspodar (PSC 833) combined with daunorubicin and cytarabine in patients with relapsed and primary refractory acute myeloid leukemia
  • 2003
  • Ingår i: Leukemia research. - 0145-2126 .- 1873-5835. ; 27, s. 323-
  • Tidskriftsartikel (refereegranskat)abstract
    • The cyclosporine analog Valspodar (PSC 833, Novartis Pharma) is a strong inhibitor of the mdr1 gene product p-glycoprotein (pgp). A phase I/II study was conducted in order to evaluate if addition of Valspodar to treatment with daunorubicin and cytarabine, given to patients with primary refractory or relapsed acute myeloid leukemia, could increase the complete remission rate. Fifty-three patients were treated in cohorts of three to six patients. Twelve patients reached a complete remission in bone marrow, five of whom also normalized their peripheral blood values. Three patients experienced treatment-related deaths from pneumonia, liver failure and cerebral hemorrhage, respectively. It is concluded that Valspodar 10mg/kg per 24h in combination with daunorubicin 45mg/m2 for 3 days and cytarabine 1g/m2 twice daily for 4 days is tolerable in this heavily pre-treated group of patients. Due to the moderate treatment results, the phase II part of the study was ended prematurely. The modulation of only pgp did not give an obvious improvement of the treatment results in this group of patients. ⌐ 2002 Elsevier Science Ltd. All rights reserved.
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  • Walter, F., et al. (författare)
  • A production line for forest stem volume measurements from VHF SAR data
  • 2003
  • Ingår i: IEEE "Geoscience and Remote Sensing Symposium (IGARSS), Toulouse, France, 21-25 July. - 0780379292 ; IV, s. 2544-6
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • Retrieval of forest stem volume has been the main civilian application investigated for VHF SAR data during recent years. Based on promising results obtained from previous studies, a project was defined with the objective to develop a fully integrated system for retrieval of stem volume at high spatial resolution from CARABAS-II VHF SAR images. Using the developed production line, stem volume can easily be retrieved within predefined forest stands or within homogeneous areas defined by segmentation of optical satellite images. In order to evaluate the accuracy and efficiency of the production line, CARABAS-II images have been collected and analyzed over a test area covering 25*25 km/sup 2/. The major part of the area is owned by the Swedish forest company Holmen Skog AB. For coniferous forest stands, exhibiting normal forest production conditions, the accuracy in terms of root mean square error (RMSE) for estimation of forest stem volume is about 44 m/sup 3/ ha/sup -1/ (22% of the average stem volume) in the range of 70-400 m/sup 3/ ha/sup -1/, using the developed production line. In comparison to earlier research tools, the developed production line speeds up the analyses approximately 10 times
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  • Resultat 1-9 av 9

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