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Exploitation of Hos...
Exploitation of Host Signal Transduction Pathways Induced by Streptococcus pneumoniae
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- Bergmann, Simone (författare)
- Technical University of Braunschweig
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- Agarwal, Vaibhav (författare)
- Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups,Deutsche Forschungsgemeinschaft (DFG)
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- Hammerschmidt, Sven (författare)
- University of Greifswald
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(creator_code:org_t)
- 2015
- 2015
- Engelska 16 s.
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Ingår i: Streptococcus Pneumoniae : Molecular Mechanisms of Host-Pathogen Interactions - Molecular Mechanisms of Host-Pathogen Interactions. - 9780124105300 - 9780124114531 ; , s. 347-362
- Relaterad länk:
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http://dx.doi.org/10...
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visa fler...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The induction of host signal transduction cascades by bacterial pathogens contributes directly to their virulence. In addition to the pore-forming cytolysin pneumolysin, several surface-exposed proteins of Streptococcus pneumoniae are also potent modulators of complex host signaling pathways. These pneumococcal surface proteins either directly mediate adhesion of pneumococci to specific cell surface receptors or recruit extracellular matrix or serum components as molecular bridges for binding to cellular receptors. In turn, adhesion triggers and subverts host signal transduction cascades to promote pneumococcal translocation across tissue barriers and dissemination within host tissues. This chapter summarizes the current knowledge of how pneumolysin and major adhesins manipulate host signaling pathways. The chapter will provide a structured overview of the signaling profiles induced by pneumococci, focusing on the receptors required and comparing the key signaling molecules and intracellular responses involved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- Adhesion
- Extracellular matrix
- Integrin
- Pneumolysin
- Signal transduction
- Streptococcus pneumoniae
- Surface protein
Publikations- och innehållstyp
- kap (ämneskategori)
- ref (ämneskategori)
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