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- Kawai, M., et al.
(författare)
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Comparison of the efficacy of salmeterol/fluticasone propionate combination in Japanese and Caucasian asthmatics
- 2007
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Ingår i: Respir Med. - : Elsevier BV. - 0954-6111. ; 101:12, s. 2488-94
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: The effect of ethnicity on the efficacy of salmeterol (S)+fluticasone propionate (FP) has not been examined in Japanese and Caucasian asthmatics. In this study, the efficacy of combination treatment with S and FP from a single inhaler (SFC) was compared with concurrent treatment with S and FP administration from separate inhalers (S+FP) in Japanese and Caucasian asthmatics. METHODS: This was a randomised, double-blind, crossover study in male and female Japanese (n=18) and Caucasian (n=17) asthmatics (50-100% predicted FEV(1); >35% reversibility in sGaw). Subjects received SFC (S 50mcg/FP 250mcgb.i.d.) and S+FP (S 50mcgb.i.d.+FP 250mcgb.i.d.) for 14 days. sGaw and FEV(1) were determined 0-12h after the first and last doses. RESULTS: Treatment with both SFC and S+FP produced marked bronchodilation, which was maintained 0-12h after the first dose. Baseline sGaw and FEV(1) increased up to 51% and 180mL, respectively, in Japanese subjects over 2 weeks of treatment, with similar improvements in Caucasian subjects. On Day 14 the 0-12h S+FP:SFC treatment ratios (90% CI) for sGaw AUC and peak were 1.05 (0.98, 1.12) and 1.05 (0.97, 1.14), respectively, in Japanese subjects, and 0.99 (0.92, 1.07) and 0.98 (0.89, 1.07), respectively, in Caucasian subjects, with no difference between the two ethnic groups. CONCLUSIONS: The finding of a similar significant bronchodilator response in Japanese and Caucasian asthmatics following concurrent and combination treatment with salmeterol and FP suggests that the therapeutic response to these agents is comparable and independent of ethnicity in Japanese and Caucasian asthma patients.
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- Väisänen, P, et al.
(författare)
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Adaptive optics imaging and optical spectroscopy of a multiple merger in a luminous infrared galaxy
- 2008
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 384:3, s. 886-906
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Tidskriftsartikel (refereegranskat)abstract
- We present near-infrared (NIR) adaptive optics imaging obtained with VLT/NACO and optical spectroscopy from the Southern African Large Telescope of a luminous IR galaxy (LIRG) IRAS 19115-2124. These data are combined with archival Hubble Space Telescope imaging and Spitzer imaging and spectroscopy, allowing us to study this disturbed interacting/merging galaxy, dubbed the Bird, in extraordinary detail. In particular, the data reveal a triple system where the LIRG phenomenon is dominated by the smallest of the components. One nucleus is a regular barred spiral with significant rotation, while another is highly disturbed with a surface brightness distribution intermediate to that of disc and bulge systems, and hints of remaining arm/bar structure. We derive dynamical masses in the range 3-7 × 1010Msolarfor both. The third component appears to be a 1-2 × 1010Msolar mass irregular galaxy. The total system exhibits HII galaxy-like optical line ratios and strengths, and no evidence for active galactic nucleus (AGN) activity is found from optical or mid-IR data. The star formation rate is estimated to be ~190Msolaryr-1. We also report a search for supernovae from NIR images separated by five months and search for superstar cluster candidates. We detect outflowing gas from the Bird mostly in the range 100-300 km s-1 using NaI D absorption features. Overall, the Bird shows kinematic, dynamical and emission-line properties typical for cool ultraluminous IR galaxies (ULIRGs). However, the interesting features setting it apart for future studies are its triple merger nature, and the location of its star formation peak - the strongest star formation, as revealed by Spitzer imaging, does not come from the two major K-band nuclei, but from the third irregular component. This is in contrast to the conventional view that the (U)LIRG phases are powered by infalling gas to the major nuclei of the merging spiral galaxies. Aided by simulations, we discuss scenarios where the irregular component is on its first high-speed encounter with the more massive components. Based on observations made with ESO Telescopes at the Paranal Observatory under programme 073.D-0406A, and with the Southern African Large Telescope (SALT).
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