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Träfflista för sökning "WFRF:(Hellman U) srt2:(1995-1999)"

Sökning: WFRF:(Hellman U) > (1995-1999)

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  • Mäkinen, Taija, et al. (författare)
  • Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1.
  • 1999
  • Ingår i: Journal of Biological Chemistry. - : Elsevier BV. - 0021-9258 .- 1083-351X. ; 274:30
  • Tidskriftsartikel (refereegranskat)abstract
    • Vascular endothelial growth factor B (VEGF-B) is expressed in various tissues, especially strongly in the heart, and binds selectively to one of the VEGF receptors, VEGFR-1. The two splice isoforms, VEGF-B(167) and VEGF-B(186), have identical NH(2)-terminal cystine knot growth factor domains but differ in their COOH-terminal domains which give these forms their distinct biochemical properties. In this study, we show that both splice isoforms of VEGF-B bind specifically to Neuropilin-1 (NRP1), a receptor for collapsins/semaphorins and for the VEGF(165) isoform. The NRP1 binding of VEGF-B could be competed by an excess of VEGF(165). The binding of VEGF-B(167) was mediated by the heparin binding domain, whereas the binding of VEGF-B(186) to NRP1 was regulated by exposure of a short COOH-terminal proline-rich peptide upon its proteolytic processing. In immunohistochemistry, NRP1 distribution was found to be overlapping or adjacent to known sites of VEGF-B expression in several tissues, in particular in the developing heart, suggesting the involvement of VEGF-B in NRP1-mediated signaling.
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  • ARAYA, Z, et al. (författare)
  • CHARACTERIZATION OF TAUROCHENODEOXYCHOLIC ACID 6-ALPHA-HYDROXYLASE FROM PIG-LIVER MICROSOMES
  • 1995
  • Ingår i: EUROPEAN JOURNAL OF BIOCHEMISTRY. - : SPRINGER VERLAG. ; 231:3
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • A fraction of cytochrome P-450 catalysing an efficient 6 alpha-hydroxylation of taurine-conjugated 3 alpha,7 alpha-dihydroxy-5 beta-cholanoic acid (taurochenodeoxycholic acid) was partially purified from pig liver microsomes. The specific content of cyto
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  • Resultat 1-10 av 28

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