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| 2. |
- Abdellah, Tebani, et al.
(författare)
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Integration of molecular profiles in a longitudinal wellness profiling cohort.
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies andimmune cell profiling, complementedwith gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.
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| 3. |
- Björn, Hellström
(författare)
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Universell utformning i den kommunala samhällsbyggnadsprocessen : Om konsten att bygga en organisation med spelrum för reflektion, kreativitet och professionellt omdöme
- 2022
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Ingår i: Jämlik livsmiljö. - Stockholm : Kungliga tekniska högskolan. ; , s. 17-46
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Avsikten med universell utformning är att behovsägare med olika individuella krav ska göras delaktiga i samhällsstyrningen så tidigt som möjligt och genom hela förloppet via designlösningar i form av tjänster och produkter som svarar mot behoven. Syftet med den här studien är att utreda Uppsala kommuns arbete med tillgänglighetsfrågor, med särskilt fokus på universell utformning. Det handlar framför allt om att belysa universella utmaningsmöjligheter och -svårheter som kan hänföras till kommunal processtyrning med fokus på följande centrala faktorer:BegreppspreciseringOrganisationSamverkanPlaneringStyrning Studien utgår från närläsning av fjorton kommunala styrdokument som hanterar frågor om tillgänglighet och universell utformning, upprättade i Uppsala under perioden 2015–2020. Därutöver har elva tjänstepersoner i Uppsala kommun och Uppsala Funktionsrätt djupintervjuats.Ambitionen är inte att precisera explicita råd, kravkriterier, indikatorer, checklistor, standardiserade metoder och andra former av styrmedel. Utgångspunkten är att precisera frågor – inte genom förenklingar och generaliseringar – utan med hänsyn till komplexa förutsättningar i relation till omvärldsfaktorer som stöd för att komma närmare en förståelse för universell utformning som processdrivet angreppssätt. Därutöver innefattar studien en uppsättning öppet formulerade rekommendationer, med ambitionen att bidra med kunskap om hur universell utformning skulle kunna genomsyra den kommunala samhällsbyggnadsprocessens olika skeden.I studien ställs följande fråga: Hur kan man bygga en organisation med spelrum för reflektion, kreativitet och professionellt omdöme? Många organisationer hämmar detta spelrum genom att skapa ledningssystem med regler och rutiner som har motverkande effekt. Studiens genomgående tema handlar därför om hur angreppssättet universell utformning kan tillämpas i samhällsbyggnadsprocessen som medger spelrum för den kreativa byråkraten.
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| 5. |
- Kulkov, Ignat, et al.
(författare)
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The importance of financial resources and ownership of intellectual property rights for university spin-offs : the cases of Finland and Sweden
- 2020
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Ingår i: Journal of Small Business and Enterprise Development. - : Emerald Group Publishing Limited. - 1462-6004 .- 1758-7840. ; 27:7, s. 1125-1147
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: This paper focuses on medical device university spin-offs (USOs), taking into account the peculiarities of financial and nonfinancial support and intellectual property rights (IPRs). The authors declare that these parameters play a significant role in business development at the early stages. Design/methodology/approach: This empirical data consist of individual and group interviews in Finland and Sweden, which are later inductively analyzed. Findings: The results show that public financial support contributes to the formation and start of sales stages in small countries and local markets. However, at the validation stage, approaches for supporting entrepreneurship in the field of medical devices may differ. The ownership of IPRs assists in the development of entrepreneurship in the region due to the transfer of research results and researchers to the industry and increases the number of spin-offs and the cooperation of universities with business. Originality/value: This contribution is in the identification of the key parameters for the formation, support and development of the USOs from the point of view of the availability of financial resources and the ownership of IPRs.
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| 6. |
- Mellner, Carl, et al.
(författare)
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Increased risk for postoperative periprosthetic fracture in hip fracture patients with the Exeter stem than the anatomic SP2 Lubinus stem
- 2021
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Ingår i: European Journal of Trauma and Emergency Surgery. - : Springer. - 1863-9933 .- 1863-9941. ; 47, s. 803-809
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The purpose of this study was to compare the cumulative incidence of postoperative periprosthetic fracture (PPF) in a cohort of femoral neck fracture (FNF) patients treated with two commonly used cemented stems: either a collarless, polished, tapered Exeter stem or the anatomic Lubinus SP2 stem.METHODS: In this retrospective multicenter cohort study of a consecutive series of patients, we included 2528 patients of age 60 years and above with an FNF who were treated with either hemiarthroplasty or total hip arthroplasty using either a polished tapered Exeter stem or an anatomic Lubinus SP2 stem. The incidence of PPF was assessed at a minimum of 2 years postoperatively.RESULTS: The incidence of PPF was assessed at a median follow-up of 47 months postoperatively. Thirty nine patients (1.5%) sustained a PPF at a median of 27 months (range 0-96 months) postoperatively. Two of the operatively treated fractures were Vancouver A (5%), 7 were Vancouver B1 (18%), 10 were Vancouver B2 (26%), 7 were Vancouver B3 (18%), and 13 were Vancouver C (32%). The cumulative incidence of PPF was 2.3% in the Exeter group compared with 0.7% in the SP2 group (p < 0.001). The HR was 5.4 (95% CI 2.4-12.5, p < 0.001), using the SP2 group as the denominator.CONCLUSIONS: The Exeter stem was associated with a higher risk for PPF than the Lubinus SP2 stem. We suggest that the tapered Exeter stem should be used with caution in the treatment of FNF.TRIAL REGISTRATION: The study was registered at clinicaltrials.gov (identifier: NCT03326271).
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| 7. |
- Nedlich, Kristin, 1983-, et al.
(författare)
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Sketching Architectural Sound Design Using Virtual Reality
- 2022
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Ingår i: Proceedings Internoise 2022. - : International Institute of Noise Control Engineering.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A sketch is an important tool that architects use to visualize and formulate design decisions.The sketch process is a crucial stage where design iterations and decisions can be made fast, easy and abundant. Sketching facilitates idea spawning, design assessment, modification and communication. This exploratory study focuses on qualities with Virtual Reality that can be used for sketching sound in the architectural design process. The study was influenced by Contextual Inquiry Interviews and used trained architects as respondents. The main result of this study is a summary of the pros and cons on how Virtual Reality work today and discusses how to develop a test bed for future research. One of the main cons, as of now, is the bulkiness of the equipment and the fact that it is not intended for sketching sound, yet. Computing speeds and acoustic rendering is another issue on the technical side. A possible benefit of using Virtual Reality is that it gives architects the possibility of incorporating sound in the architectural design process, thus making it an integral part of the practice.
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| 8. |
- Nedlich, Kristin, 1983-, et al.
(författare)
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Spatio-sonic site survey using ambisonics recordings and VR rendering — designing soundscapes in the early planning process
- 2023
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Ingår i: 2023 AES International Conference on Spatial and Immersive Audio. - : Audio Engineering Society, Inc..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- As a part of the on-going city move in Malmberget, Gällivare, the inhabitants of Malmberget mining area need not only new housing but also increased communal services. To accommodate this, the municipality is building a new public building called the Multiactivitiy building. The building will house public services such as: library, sports centre, swimming pools and recreational spaces. The central lobby space creates a hub which connects the different parts of the building and serves as a communal meeting place. The proposed building site, and the site of this study, is in the centre of downtown Gällivare. The study focuses on how ambisonics recordings can be used as a part of the site survey in the early stages of the architectural design process. The spatio-sonic qualities of the existing site are integral to the architectural design process, not only as documentation and analysis of the site’s conditions, but as an integrated design parameter (on par with lighting, climatic, contextual, and other site-specific conditions). A Virtual Reality model of the site, auralized with ambisonics recordings, is the main artefactual outcome of this study. Additional documentation of the site survey includes spatio-sonic mapping of the site plan, written (autoethnographic) impressions from the main surveyor, photographs, ambisonics recordings and a summary and analysis of respondents’ answers to questionnaires in combination with soundwalks. The conclusion of the study is that it is feasible to produce simple, virtual, auralized models that can be used as a base for sketching with sound in architecture.
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