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- Ahlberg, Mats Steinholtz, et al.
(författare)
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PCASTt/SPCG-17-A randomised trial of active surveillance in prostate cancer: Rationale and design
- 2019
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Overtreatment of localised prostate cancer is substantial despite increased use of active surveillance. No randomised trials help define how to monitor patients or when to initiate treatment with curative intent. Methods and analysis A randomised, multicentre, intervention trial designed to evaluate the safety of an MRI-based active surveillance protocol, with standardised triggers for repeated biopsies and radical treatment. The aim is to reduce overtreatment of prostate cancer. 2000 men will be randomly allocated to either surveillance according to current practice or to standardised triggers at centres in Sweden, Norway, Finland and the UK. Men diagnosed in the past 12 months with prostate cancer, ≤T2a, prostate-specific antigen (PSA) <15 ng/mL, PSA density ≤0.2 ng/mL/cc, any International Society of Urological Pathology (ISUP) grade 1 are eligible. Men with ISUP grade 2 in <30% of cores on systematic biopsy and <10 mm cancer in one core on systematic or targeted biopsy are also eligible. Men diagnosed on systematic biopsy should have an MRI and targeted biopsies against Prostate Imaging and Reporting Data System V.2 3-5 lesions before inclusion. Identical follow-up in the two study arms: biannual PSA testing, yearly clinical examination and MRI every second year. In the experimental arm, standardised triggers based on MRI and PSA density elicit repeated biopsies. MRI and histopathological progression trigger radical treatment. Primary outcome measure is progression-free survival. Secondary outcome measures are cumulative incidence of metastatic disease, treatments with curative intent, pT3-4 at radical prostatectomy, switch to watchful waiting, prostate cancer mortality and quality of life. Inclusion started in October 2016 and in October 2018; 275 patients have been enrolled. Ethics and dissemination Ethical approval was obtained in each participating country. Results for the primary and secondary outcome measures will be submitted for publication in peer-reviewed journals. Trial registration number NCT02914873.
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| 2. |
- Berndt, Adele, 1966-, et al.
(författare)
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Mobilapplikationer inom dagligvaruhandeln Konsumtionens medialisering genom nya digitala tjänster
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Projektet “Medialiserad shopping” utforskar den växande andelen digitala element inom detaljhandeln, samt hur nya tekniska verktyg förändrar shopping som vardagsrutin och kundupplevelse. Materialet belyser hur kunderna upplever den nya teknikens roll och visar samtidigt på de driv krafter som ligger bakom digital innovation bland detaljhandlare. Rapporten sammanfattar det arbete som utförts inom projektet och tar upp frågor kring utvecklingen och användningen av digitala medier inom omnikanalhandeln. Under 2015–2016 genomförde forskare vid Jönköping University och Göteborgs universitet en serie studier av matvarubutikernas omnikanalmiljö i vilka kunder och andra intressenter deltog. En rad olika metoder för datainsamling användes, till exempel enkäter som besvarades av cirka 500 kunder, djupintervjuer och deltagande observationer av konsumenter, kunddagböcker och fler än 150 videoobservationer. • Kvantitativa data visar på ett växande antal användare av shoppingappar, men att användningsgraden ökar långsammare än förväntat. • Appanvändning och besöksfrekvens går hand i hand, vilket kan tolkas som att appanvändarna är mer butikslojala än genomsnittskunden. • Vidare ser inte kunderna appen som ett sammanhållet teknologiskt servicepaket, utan väljer ut de funktioner som motsvarar deras specifika behov och struntar i resten. • Än så länge har introduktionen av den nya tekniken inte förändrat beteendemönstren i någon större utsträckning. Funktionerna är normalt sett utformade så att de härmar redan existerande verktyg och kundvanor. I den mån kunderna använder mobila enheter i butiken handlar detta enbart om att ersätta gammal teknik, som till exempel papper och penna för att hålla reda på inköpslistan eller handenheten vid självskanning. • Kvalitativa data insamlade genom intervjuer med, observationer av och dagböcker skrivna av konsumenter visar att mobiltelefonen uppfyller en rad emotionella och praktiska funktioner under shoppingen, men att detaljhandlarna inte alls har tagit fasta på de emotionella aspekterna. • När det gäller detaljhandlarna beskriver rapporten tre huvudsakliga drivkrafter som påverkar apputvecklingen: i) handlarnas uppfattning av konkurrensmiljön, ii) utvecklingen av kunders köpbeteenden, samt iii) organisatoriska begränsningar, det vill säga i vilken utsträckning organisationens försörjningskedjor och distributions- strukturer tillåter att handlaren skapar nya tjänster baserat på mobil teknik.
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| 3. |
- Bhatt, Deepak L., et al.
(författare)
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Rationale, design and baseline characteristics of the effect of ticagrelor on health outcomes in diabetes mellitus patients Intervention study
- 2019
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Ingår i: Clinical Cardiology. - : Wiley. - 0160-9289 .- 1932-8737. ; 42:5, s. 498-505
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Tidskriftsartikel (refereegranskat)abstract
- In the setting of prior myocardial infarction, the oral antiplatelet ticagrelor added to aspirin reduced the risk of recurrent ischemic events, especially, in those with diabetes mellitus. Patients with stable coronary disease and diabetes are also at elevated risk and might benefit from dual antiplatelet therapy. The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS, NCT01991795) is a Phase 3b randomized, double-blinded, placebo-controlled trial of ticagrelor vs placebo, on top of low dose aspirin. Patients >= 50 years with type 2 diabetes receiving anti-diabetic medications for at least 6 months with stable coronary artery disease as determined by a history of previous percutaneous coronary intervention, bypass grafting, or angiographic stenosis of >= 50% of at least one coronary artery were enrolled. Patients with known prior myocardial infarction (MI) or stroke were excluded. The primary efficacy endpoint is a composite of cardiovascular death, myocardial infarction, or stroke. The primary safety endpoint is Thrombolysis in Myocardial Infarction major bleeding. A total of 19 220 patients worldwide have been randomized and at least 1385 adjudicated primary efficacy endpoint events are expected to be available for analysis, with an expected average follow-up of 40 months (maximum 58 months). Most of the exposure is on a 60 mg twice daily dose, as the dose was lowered from 90 mg twice daily partway into the study. The results may revise the boundaries of efficacy for dual antiplatelet therapy and whether it has a role outside acute coronary syndromes, prior myocardial infarction, or percutaneous coronary intervention.
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| 4. |
- Cochoy, Franck, 1964, et al.
(författare)
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Bicycles, cyclists and loads: a comparative analysis of cycling practices in Gothenburg and Toulouse
- 2019
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Ingår i: Applied Mobilities. - : Informa UK Limited. - 2380-0127 .- 2380-0135. ; 4:1, s. 1-25
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Tidskriftsartikel (refereegranskat)abstract
- This article reports on a video-based analysis of bicycling practices in Gothenburg and Toulouse. It is based on actor-network theory, an approach that studies human and non-human entities and their contributions to social action equally. The paper examines bicycles and their interactions with cyclists and loads in the transport of people and goods. Accordingly, this paper presents methodological, theoretical and empirical contributions to the study of bicycle transportation as a possible method for developing sustainable urban environments. This paper also presents an innovative way to study ordinary social practices and describes how these practices shape associated societal issues.
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| 5. |
- Hagberg, Johan, 1973, et al.
(författare)
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Travel modes in grocery shopping
- 2017
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Ingår i: International Journal of Retail & Distribution Management. - 0959-0552. ; 45:9, s. 991-1010
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Tidskriftsartikel (refereegranskat)abstract
- Purpose Although the movement of goods by consumers represents a large proportion of the economic and environmental impact of the distribution chain, this topic has been insufficiently explored in the retailing literature. The purpose of this paper is to contribute to the understanding of shopping travel-mode choice in the context of grocery shopping. Design/methodology/approach The paper presents findings from a Swedish national survey of 1,694 respondents that included questions regarding travel-mode choices and consumer characteristics, mobility conditions, shopping behaviours and environmental interests and engagements. Findings This paper shows how travel modes interrelate and how various consumer characteristics, shopping behaviours, mobility conditions and environmental interests and engagements relate to and affect travel-mode choice in grocery shopping. General travel patterns and distance to store are shown to be the most important factors in explaining the mode of transport for grocery shopping. Originality/value This paper presents data from a national representative survey and provides novel analyses of travel-mode choices in grocery shopping and the interrelationships among those choices, in addition to the interrelationship between travel-mode choice and the use of home delivery. This paper contributes to a further understanding of consumer mobility in the context of grocery shopping.
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| 10. |
- Holmberg, Ulrika, 1966, et al.
(författare)
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Constructing a sustainable future
- 2018
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Ingår i: Nordic Conference on Consumer Research, Vaasa, 12-14 June, 2018.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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