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- Harrington, Robert A., et al.
(författare)
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The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA.CER) trial : study design and rationale
- 2009
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Ingår i: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 158:3, s. 327-334
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Tidskriftsartikel (refereegranskat)abstract
- Background The protease-activated receptor 1 (PAR-1), the main platelet receptor for thrombin, represents a novel target for treatment of arterial thrombosis, and SCH 530348 is an orally active, selective, competitive PAR-1 antagonist. We designed TRA.CER to evaluate the efficacy and safety of SCH 530348 compared with placebo in addition to standard of care in patients with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) and high-risk features. Trial design TRA.CER is a prospective, randomized, double-blind, multicenter, phase III trial with an original estimated sample size of 10,000 subjects. Our primary objective is to demonstrate that SCH 530348 in addition to standard of care will reduce the incidence of the composite of cardiovascular death, myocardial infarction (MI), stroke, recurrent ischemia with rehospitalization, and urgent coronary revascularization compared with standard of care alone. Our key secondary objective is to determine whether SCH 530348 will reduce the composite of cardiovascular death, MI, or stroke compared with standard of care alone. Secondary objectives related to safety are the composite of moderate and severe GUSTO bleeding and clinically significant TIMI bleeding. The trial will continue until a predetermined minimum number of centrally adjudicated primary and key secondary end point events have occurred and all subjects have participated in the study for at least I year. The TRA.CER trial is part of the large phase III SCH 530348 development program that includes a concomitant evaluation in secondary prevention. Conclusion TRA.CER will define efficacy and safety of the novel platelet PAR-1 inhibitor SCH 530348 in the treatment of high-risk patients with NSTE ACS in the setting of current treatment strategies.
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| 4. |
- Hartke, René, et al.
(författare)
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Experimental study of the output dynamics of intracavity frequency doubled optically pumped semiconductor disk lasers
- 2008
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Ingår i: Applied Physics Letters. - : American Institute of Physics. - 0003-6951 .- 1077-3118. ; 92:10
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Tidskriftsartikel (refereegranskat)abstract
- The dynamic behavior of the continuous wave output of an intracavity frequency doubled optically pumped semiconductor disk laser is described. These lasers typically exhibit stable emission. The reasons are found to be the tendency to single-mode operation and the high gain coupling of different modes due to an extremely short gain medium and the resonant periodic gain structure. A dependence of the fluctuation amplitude on gain decoupling of different fundamental modes is demonstrated. With the presented laser setup, more than 80% of conversion efficiency with respect to the available fundamental power has been achieved.
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| 5. |
- Huber, Jürgen, et al.
(författare)
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Is more information always better? Experimental financial markets with cumulative information
- 2008
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Ingår i: Journal of Economic Behavior and Organization. - 0167-2681. ; 65:1, s. 86-104
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Tidskriftsartikel (refereegranskat)abstract
- We study the value of information in financial markets by asking whether having more information always leads to higher returns. We address this question in an experiment where information about an asset's intrinsic value is cumulatively distributed among traders. We find that only the very best informed traders (i.e., insiders) significantly outperform less informed traders. However, there is a wide range of information levels (from zero information to above average information levels) where additional information does not yield higher returns. The latter result implies that the value of additional information need not be strictly positive.
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| 6. |
- Huber, Stephan J., et al.
(författare)
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Electroweak phase transition and baryogenesis in the nMSSM
- 2006
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Ingår i: Nuclear Physics B. - : Elsevier BV. - 0550-3213 .- 1873-1562. ; 757:1-2, s. 172-196
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Tidskriftsartikel (refereegranskat)abstract
- We analyze the nMSSM with CP violation in the singlet sector. We study the static and dynamical properties of the electroweak phase transition. We conclude that electroweak baryogenesis in this model is generic in the sense that if the present limits on the mass spectrum are applied, no severe additional tuning is required to obtain a strong first-order phase transition and to generate a sufficient baryon asymmetry. For this we determine the shape of the nucleating bubbles, including the profiles of CP-violating phases. The baryon asymmetry is calculated using the advanced transport theory to first and second order in gradient expansion presented recently. Still, first and second generation sfermions must be heavy to avoid large electric dipole moments.
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