| 1. |
- Anthony, Lowell B., et al.
(författare)
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Long-Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome
- 2019
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Ingår i: The Oncologist. - : WILEY. - 1083-7159 .- 1549-490X. ; 24:8, s. E662-E670
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Tidskriftsartikel (refereegranskat)abstract
- Background Patients with neuroendocrine tumors (NETs) and carcinoid syndrome experience considerable morbidity and mortality; carcinoid syndrome may be associated with shorter survival. Carcinoid syndrome is linked to tumoral secretion of serotonin and other bioactive substances. The subsequent debilitating diarrhea and urgency to defecate pose significant health risks. In previous studies, telotristat ethyl, a tryptophan hydroxylase inhibitor, was effective and well tolerated in treating carcinoid syndrome diarrhea. We present pooled safety data from five clinical trials with telotristat ethyl in patients with carcinoid syndrome. Subjects, Materials, and Methods Adverse events reported during telotristat ethyl treatment were pooled from two phase II and three phase III clinical trials in 239 patients with carcinoid syndrome. Long-term safety of telotristat ethyl and causes of hospitalization and death were reviewed; overall survival was estimated. Results Mean (median; range) duration of exposure and follow-up was 1.3 years (1.1 years; 1 week to 5.7 years), with 309 total patient-years of exposure. Leading causes of hospitalization were gastrointestinal disorders or were related to the underlying tumor and related treatment. Survival estimates at 1, 2, and 3 years were 93%, 88%, and 77%. Nearly all deaths were due to progression or complication of the underlying disease; none were attributable to telotristat ethyl. There was one death in year 4. Conclusion Based on long-term safety data, telotristat ethyl is well tolerated and has a favorable long-term safety profile in patients with carcinoid syndrome. Implications for Practice Carcinoid syndrome can cause persistent diarrhea, even in patients treated with somatostatin analogs. Across five clinical trials in patients with carcinoid syndrome, telotristat ethyl has been well tolerated and efficacious, providing clinicians with a new approach to help control carcinoid syndrome diarrhea, in addition to somatostatin analog therapy. By reducing the stool frequency in patients with carcinoid syndrome whose diarrhea is refractory to anticholinergics, such as loperamide and atropine/diphenoxylate, and somatostatin analog dose escalation, improvement in quality of life becomes an achievable goal.
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| 2. |
- Kristanl, Matej, et al.
(författare)
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The Seventh Visual Object Tracking VOT2019 Challenge Results
- 2019
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Ingår i: 2019 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW). - : IEEE COMPUTER SOC. - 9781728150239 ; , s. 2206-2241
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Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge VOT2019 is the seventh annual tracker benchmarking activity organized by the VOT initiative. Results of 81 trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis as well as the standard VOT methodology for long-term tracking analysis. The VOT2019 challenge was composed of five challenges focusing on different tracking domains: (i) VOT-ST2019 challenge focused on short-term tracking in RGB, (ii) VOT-RT2019 challenge focused on "real-time" short-term tracking in RGB, (iii) VOT-LT2019 focused on long-term tracking namely coping with target disappearance and reappearance. Two new challenges have been introduced: (iv) VOT-RGBT2019 challenge focused on short-term tracking in RGB and thermal imagery and (v) VOT-RGBD2019 challenge focused on long-term tracking in RGB and depth imagery. The VOT-ST2019, VOT-RT2019 and VOT-LT2019 datasets were refreshed while new datasets were introduced for VOT-RGBT2019 and VOT-RGBD2019. The VOT toolkit has been updated to support both standard short-term, long-term tracking and tracking with multi-channel imagery. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website(1).
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| 3. |
- Liu, Runnan, et al.
(författare)
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Detecting Abrupt Change in Channel Covariance Matrix for MIMO Communication
- 2023
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Ingår i: IEEE Transactions on Wireless Communications. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 1536-1276 .- 1558-2248. ; 22:11, s. 7834-7847
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Tidskriftsartikel (refereegranskat)abstract
- The acquisition of the channel covariance matrix is of paramount importance to many strategies in multiple-input-multiple-output (MIMO) communications, such as the minimum mean-square error (MMSE) channel estimation. Therefore, plenty of efficient channel covariance matrix estimation schemes have been proposed in the literature. However, an abrupt change in the channel covariance matrix may happen occasionally in practice due to the change in the scattering environment and the user location. Our paper aims to adopt the classic change detection theory to detect the change in the channel covariance matrix as accurately and quickly as possible such that the new covariance matrix can be re-estimated in time. Specifically, this paper first considers the technique of on-line change detection (also known as quickest/sequential change detection), where we need to detect whether a change in the channel covariance matrix occurs at each channel coherence time interval. Next, because the complexity of detecting the change in a high-dimension covariance matrix at each coherence time interval is too high, we devise a low-complexity off-line strategy in massive MIMO systems, where change detection is merely performed at the last channel coherence time interval of a given time period. Numerical results show that our proposed on-line and off-line schemes can detect the channel covariance change with a small delay and a low false alarm rate. Therefore, our paper theoretically and numerically verifies the feasibility of detecting the channel covariance change accurately and quickly in practice.
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| 4. |
- Liu, Runnan, et al.
(författare)
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Detection of Abrupt Change in Channel Covariance Matrix for Multi-Antenna Communication
- 2021
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Ingår i: 2021 IEEE GLOBAL COMMUNICATIONS CONFERENCE (GLOBECOM). - : IEEE. - 9781728181042
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Konferensbidrag (refereegranskat)abstract
- The knowledge of channel covariance matrices is of paramount importance to the estimation of instantaneous channels and the design of beamforming vectors in multi-antenna systems. In practice, an abrupt change in channel covariance matrices may occur due to the change in the environment and the user location. Although several works have proposed efficient algorithms to estimate the channel covariance matrices after any change occurs, how to detect such a change accurately and quickly is still an open problem in the literature. In this paper, we focus on channel covariance change detection between a multiantenna base station (BS) and a single-antenna user equipment (UE). To provide theoretical performance limit, we first propose a genie-aided change detector based on the log-likelihood ratio (LLR) test assuming the channel covariance matrix after change is known, and characterize the corresponding missed detection and false alarm probabilities. Then, this paper considers the practical case where the channel covariance matrix after change is unknown. The maximum likelihood (ML) estimation technique is used to predict the covariance matrix based on the received pilot signals over a certain number of coherence blocks, building upon which the LLR-based change detector is employed. Numerical results show that our proposed scheme can detect the change with low error probability even when the number of channel samples is small such that the estimation of the covariance matrix is not that accurate. This result verifies the possibility to detect the channel covariance change both accurately and quickly in practice.
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| 5. |
- Xiong, Min, et al.
(författare)
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Tailoring Phase Purity in the 2D/3D Perovskite Heterostructures Using Lattice Mismatch
- 2022
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Ingår i: ACS Energy Letters. - : AMER CHEMICAL SOC. - 2380-8195. ; 7:1, s. 550-559
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Tidskriftsartikel (refereegranskat)abstract
- Although the fabrication of two-dimensional (2D)/three-dimensional (3D) halide perovskite heterostructures has been employed to balance the long-term stability and high efficiency of perovskite solar cells, the formation of metastable quasi-2D perovskites remains the most serious challenge. Here, we demonstrate that large lattice mismatch derived from halide and cation differences between 2D and 3D perovskites are key to avoiding the formation of unintended 2D phases in the preparation of 2D/3D bulk heterostructure because the phase transformation becomes less thermodynamically favorable. Specifically, by employing chloride 2D perovskite (PYA)(2) PbCl4 (PYA = propargylammonium) crystals into a 3D precursor solution, we achieve a phase-pure 2D/3D heterojunction with clean type-I band alignment, which exhibits greatly reduced charge recombination. Furthermore, the incorporation of alkyne perovskites is also shown to suppress iodine diffusion and formation due to their exceptional iodine capture capacity. The resultant 2D/3D heterostructured devices exhibited enhanced efficiencies and stabilities compared with their 3D counterparts.
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