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- Eriksson, Hanna, et al.
(author)
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Low level of education is associated with later stage at diagnosis and reduced survival in cutaneous malignant melanoma : A nationwide population-based study in Sweden
- 2013
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In: European Journal of Cancer. - Oxford : Elsevier. - 0959-8049 .- 1879-0852. ; 49:12, s. 2705-2716
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Journal article (peer-reviewed)abstract
- BACKGROUND:A worse outcome has been reported for cutaneous malignant melanoma (CMM) patients with low socioeconomic status. We have investigated the association between level of education, clinical stage at diagnosis (stage at diagnosis) and CMM-specific survival in Sweden.METHODS:We identified 27,235 patients from the Swedish Melanoma Register diagnosed with a primary invasive CMM between 1990 and 2007 and linked data to nationwide, population-based, health and census registers with a follow-up to 2010.RESULTS:The odds ratio (OR) of higher disease stage at diagnosis was significantly increased in lower education groups (OR stage II versus I=1.6; 95% confidence interval (CI)=1.5-1.7. OR stage III-IV versus I=2.3; 95% CI=1.8-2.9). The risk of dying of CMM, was significantly increased in patients with low (hazard ratio (HR) low versus high=2.02; 95% CI=1.80-2.26; p<0.0001) and intermediate (HR intermediate versus high=1.35; 95% CI=1.20-1.51; p<0.0001) level of education. After adjustment for age, gender, stage at diagnosis and other known prognostic factors, the HRs remained significant for low versus high (HR=1.13; 95% CI=1.01-1.27; p=0.04) but not for intermediate versus high (HR=1.11; 95% CI=0.99-1.24; p=0.08) education. The HR associated with low level of education was significantly higher among female patients, patients <55years, patients with truncal tumours and during the first 5years after diagnosis.CONCLUSION:Lower level of education is associated with reduced CMM-specific survival, which may at least partially be attributed to a more advanced stage at diagnosis. These results emphasise the need for improved early detection strategies.
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- Lindholm, Carl-Johan, et al.
(author)
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Experimental analysis of stresses in curved sandwich structures
- 2015
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In: 20th International Conference on Composite Materials.
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Conference paper (other academic/artistic)abstract
- Some studies indicate that the cross-section of large wind turbine blades subjected to wind and gravity loads will ovalise due to the Brazier effects [1,2]. This feature could however not be verified by numerical experiments of a FE model of a fictive 61.5 m blade, based on the NREL 5MW reference turbine [3], subjected to simplified load cases. Accurate prediction of failure modes of sandwich structures based on finite element calculations are highly important if accurate predictions of such features in large wind turbine blades are to be investigated.In this study, an experimental setup designed to cause deflection and stress patterns in the core similar to what might be achieved by the Brazier effect in a wind turbine blade subjected to severe wind loads has been carried out. The test set up will highlight stress in the through-thickness direction, causing classical shell theory to be circumspect as a modelling tool. By designing specimens with different foam core material properties, stiffness and strength, different failure modes were observed in the test. Through the use of combinations of solid and shell elements and geometrically nonlinear analyses, the experimental effects were shown to be predictable by an otherwise linear FE model.
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| 4. |
- Lindholm, Carl-Johan, et al.
(author)
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Experimental analysis of stresses in sandwich structures due to the brazier effect
- 2015
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In: ICCM International Conferences on Composite Materials. ; 2015-July
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Conference paper (peer-reviewed)abstract
- © 2015 International Committee on Composite Materials. All rights reserved. Some studies indicate that the cross-section of large wind turbine blades subjected to wind and gravity loads will ovalise due to the Brazier effects [1,2]. This feature could however not be verified by numerical experiments of a FE model of a fictive 61.5 m blade, based on the NREL 5MW reference turbine [3], subjected to simplified load cases. Accurate prediction of failure modes of sandwich structures based on finite element calculations are highly important if accurate predictions of such features in large wind turbine blades are to be investigated. In this study, an experimental setup designed to cause deflection and stress patterns in the core similar to what might be achieved by the Brazier effect in a wind turbine blade subjected to severe wind loads has been carried out. The test set up will highlight stress in the through-thickness direction, causing classical shell theory to be circumspect as a modelling tool. By designing specimens with different foam core material properties, stiffness and strength, different failure modes were observed in the test. Through the use of combinations of solid and shell elements and geometrically nonlinear analyses, the experimental effects were shown to be predictable by an otherwise linear FE model.
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- Malmros, Karina, et al.
(author)
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Diagnostic gastrointestinal markers in primary lung cancer and pulmonary metastases
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In: Virchows Archiv. - 0945-6317.
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Journal article (peer-reviewed)abstract
- Histopathological diagnosis of pulmonary tumors is essential for treatment decisions. The distinction between primary lung adenocarcinoma and pulmonary metastasis from the gastrointestinal (GI) tract may be difficult. Therefore, we compared the diagnostic value of several immunohistochemical markers in pulmonary tumors. Tissue microarrays from 629 resected primary lung cancers and 422 resected pulmonary epithelial metastases from various sites (whereof 275 colorectal cancer) were investigated for the immunohistochemical expression of CDH17, GPA33, MUC2, MUC6, SATB2, and SMAD4, for comparison with CDX2, CK20, CK7, and TTF-1. The most sensitive markers for GI origin were GPA33 (positive in 98%, 60%, and 100% of pulmonary metastases from colorectal cancer, pancreatic cancer, and other GI adenocarcinomas, respectively), CDX2 (99/40/100%), and CDH17 (99/0/100%). In comparison, SATB2 and CK20 showed higher specificity, with expression in 5% and 10% of mucinous primary lung adenocarcinomas and both in 0% of TTF-1-negative non-mucinous primary lung adenocarcinomas (25–50% and 5–16%, respectively, for GPA33/CDX2/CDH17). MUC2 was negative in all primary lung cancers, but positive only in less than half of pulmonary metastases from mucinous adenocarcinomas from other organs. Combining six GI markers did not perfectly separate primary lung cancers from pulmonary metastases including subgroups such as mucinous adenocarcinomas or CK7-positive GI tract metastases. This comprehensive comparison suggests that CDH17, GPA33, and SATB2 may be used as equivalent alternatives to CDX2 and CK20. However, no single or combination of markers can categorically distinguish primary lung cancers from metastatic GI tract cancer.
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