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- Rahm, F., et al.
(författare)
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Preparation of chiral enantiopure 2-(hydroxyalkyl)pyridine derivatives. Use of the chiral pool
- 2000
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Ingår i: Journal of the Chemical Society-Perkin Transactions 1. - : Royal Society of Chemistry (RSC). - 1470-4358 .- 1364-5463. ; :12, s. 1983-1990
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Forskningsöversikt (refereegranskat)abstract
- Enantiomerically pure 2-(1-hydroxyalkyl)pyridines were prepared via reaction of 2-lithiopyridine with (R)-2,3-O-isopropylideneglyceraldehyde, methyl (S)-2-methoxypropionate and methyl (S)-2-methoxy-2-phenylacetate, obtained from D-mannitol, L-lactic acid and L-mandelic acid, respectively. 6,6'-Bis(1-hydroxyalkyl)-2,2'-bipyridines were obtained from the same naturally occurring chiral compounds and 2-bromo-6-lithiopyridine with subsequent Ni-catalysed coupling.
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