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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Leebens-Mack, James H., et al.
(författare)
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One thousand plant transcriptomes and the phylogenomics of green plants
- 2019
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 574:7780, s. 679-
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Tidskriftsartikel (refereegranskat)abstract
- Green plants (Viridiplantae) include around 450,000-500,000 species(1,2) of great diversity and have important roles in terrestrial and aquatic ecosystems. Here, as part of the One Thousand Plant Transcriptomes Initiative, we sequenced the vegetative transcriptomes of 1,124 species that span the diversity of plants in a broad sense (Archaeplastida), including green plants (Viridiplantae), glaucophytes (Glaucophyta) and red algae (Rhodophyta). Our analysis provides a robust phylogenomic framework for examining the evolution of green plants. Most inferred species relationships are well supported across multiple species tree and supermatrix analyses, but discordance among plastid and nuclear gene trees at a few important nodes highlights the complexity of plant genome evolution, including polyploidy, periods of rapid speciation, and extinction. Incomplete sorting of ancestral variation, polyploidization and massive expansions of gene families punctuate the evolutionary history of green plants. Notably, we find that large expansions of gene families preceded the origins of green plants, land plants and vascular plants, whereas whole-genome duplications are inferred to have occurred repeatedly throughout the evolution of flowering plants and ferns. The increasing availability of high-quality plant genome sequences and advances in functional genomics are enabling research on genome evolution across the green tree of life.
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| 3. |
- Lundgren, Markus, et al.
(författare)
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Analgesic antipyretic use among young children in the TEDDY study : No association with islet autoimmunity
- 2017
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Ingår i: BMC Pediatrics. - : Springer Science and Business Media LLC. - 1471-2431. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The use of analgesic antipyretics (ANAP) in children have long been a matter of controversy. Data on their practical use on an individual level has, however, been scarce. There are indications of possible effects on glucose homeostasis and immune function related to the use of ANAP. The aim of this study was to analyze patterns of analgesic antipyretic use across the clinical centers of The Environmental Determinants of Diabetes in the Young (TEDDY) prospective cohort study and test if ANAP use was a risk factor for islet autoimmunity. Methods: Data were collected for 8542 children in the first 2.5 years of life. Incidence was analyzed using logistic regression with country and first child status as independent variables. Holm's procedure was used to adjust for multiplicity of intercountry comparisons. Time to autoantibody seroconversion was analyzed using a Cox proportional hazards model with cumulative analgesic use as primary time dependent covariate of interest. For each categorization, a generalized estimating equation (GEE) approach was used. Results: Higher prevalence of ANAP use was found in the U.S. (95.7%) and Sweden (94.8%) compared to Finland (78.1%) and Germany (80.2%). First-born children were more commonly given acetaminophen (OR 1.26; 95% CI 1.07, 1.49; p = 0.007) but less commonly Non-Steroidal Anti-inflammatory Drugs (NSAID) (OR 0.86; 95% CI 0.78, 0.95; p = 0.002). Acetaminophen and NSAID use in the absence of fever and infection was more prevalent in the U.S. (40.4%; 26.3% of doses) compared to Sweden, Finland and Germany (p < 0.001). Acetaminophen or NSAID use before age 2.5 years did not predict development of islet autoimmunity by age 6 years (HR 1.02, 95% CI 0.99-1.09; p = 0.27). In a sub-analysis, acetaminophen use in children with fever weakly predicted development of islet autoimmunity by age 3 years (HR 1.05; 95% CI 1.01-1.09; p = 0.024). Conclusions: ANAP use in young children is not a risk factor for seroconversion by age 6 years. Use of ANAP is widespread in young children, and significantly higher in the U.S. compared to other study sites, where use is common also in absence of fever and infection.
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Architecture in effect : vol 1. Rethinking the social in architecture: making effects
- 2018
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- Architecture in Effect presents research on the co-constitution of architecture and the social by addressing concrete problems and forwarding explorative theories and methodologies. The book compromises a wide-ranging collection of essays emerging from a multi-year research collective that has brought together partners from Sweden, the Nordic countries, the United Kingdom, Europe and the United States.The socially oriented perspective of Volume #1, Rethinking the Social, is complemented by discussions of architectural and transdisciplinary theories and methodologies in Volume #2, After Effects. Together these twin volumes reflect on topics such as the utopian idea of a welfare state, the role of intersubjective and non-human points of view, and the impact of historical and current images on the making of realities. The task of these books is to present a wide range of research topics that combine historical, material, and critical research approaches that respond to our current crises and challenges. Ultimately, this enables new modes of knowledge production within architecture to be advanced in its relation to societal transformation.
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| 6. |
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Architecture in Effect Vol #1(2) : Rethinking the Social in Architecture – Making Effects.
- 2019
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Samlingsverk (redaktörskap) (refereegranskat)abstract
- Architecture in Effect is a substantial double volume that compiles 50 essays emerging from the architectural research environment of Sweden and drawing on a complex matrix of international collaborations. A central premise of the collected research is to question the relationship between the built environment and societal norms and to interrogate architecture’s role in these co-constitutive processes. The Architecture in Effect project is concerned with how contemporary political and environmental conditions place specific demands on society and on the everyday life of individuals. Architectural researchers have the capacity to both initiate and criticize architectural production and culture amidst existing and emerging societies. Architecture in Effect is published by Actar Barcelona New York (2019). Rethinking the Social in Architecture: Making Effects Volume 01 Edited by Sten Gromark, Jennifer Mack, Roemer van Toorn That architecture serves as the setting for social actions, activities, and content is not a new idea. That the architectural project can precipitate crucial social change, even transgression, is a far more modern and disputed claim. Spatial design in society has recently shifted away from universal solutions toward satisfying specific market orientated interests. The time is now to reclaim architecture’s role in promoting political, economic, ecological, and cultural transformations. The radicality of architecture is renewed in the exploration of novel and unforeseen possibilities: making effects.
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| 7. |
- Gromark, Sten, 1951, et al.
(författare)
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Architecture in Effect vol #1(2) Rethinking the Social in Architecture: Making Effects - Editors’ Introduction
- 2019
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Ingår i: Architecture in Effect vol #1(2) Rethinking the Social in Architecture: Making Effects. ; , s. 18-35
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Architecture in Effect is a substantial collection of essays emerging from the Swedish research environment of the same name. While it takes its point of departure from within the specific context that is Sweden, it includes contributions from authors based in the Nordic context, in the United Kingdom, Europe and the United States. A central premise of the collected research is that the built environment and societal norms are co-constitutive and that architecture as a discipline and as a professional practice plays a fundamental role in this relationship. Contemporary political and environmental conditions place specific demands on society and on the everyday life of individuals. There persists, as such, an obligation for actors within the discipline of architecture to contribute to a rethinking of the situated knowledges within architecture by engaging in trans-, cross-, and inter-disciplinary studies. Architectural researchers have the capacity to guide and criticize thinking on architecture and its vital material relations amidst existing and emerging societies. The socially oriented perspective of Volume #1, Rethinking the Social , is complemented by discussions of architectural and transdisciplinary theories and methodologies in Volume #2, After Effects . Together these twin volumes reflect on topics such as the utopian idea of a welfare state, the role of intersubjective and non-human points of view, and the impact of historical and current images on the making of realities – and how such themes are intertwined with the development of architecture. The collected essays draw on historical and contemporary architectural situations, as seen from socially oriented perspectives and through the use of innovative methodologies and theories. A special feature included in the collection is a heteroglossary, a lexicon that defines productive concepts for architectural research that the contributing authors activate across the two volumes. Professor Dana Cuff, UCLA, USA, has provided a perceptive foreword for the double book project. The task of these books is to present a wide range of research topics that combine historical, material, and critical research approaches that respond to our current crises and challenges. Ultimately, this enables new modes of knowledge production within architecture to be advanced in its relation to societal transformation.
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| 8. |
- Gromark, Sten, et al.
(författare)
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Rethinking the social in architecture: making effects : editors' introduction
- 2018
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Ingår i: Architecture in effect. - Barcelona, New York : ACTAR. - 9781940291994 ; , s. 19-35
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Bokkapitel (refereegranskat)abstract
- Architecture in Effect presents research on the co-constitution of architecture and the social by addressing concrete problems and forwarding explorative theories and methodologies. The book compromises a wide-ranging collection of essays emerging from a multi-year research collective that has brought together partners from Sweden, the Nordic countries, the United Kingdom, Europe and the United States.The socially oriented perspective of Volume #1, Rethinking the Social, is complemented by discussions of architectural and transdisciplinary theories and methodologies in Volume #2, After Effects. Together these twin volumes reflect on topics such as the utopian idea of a welfare state, the role of intersubjective and non-human points of view, and the impact of historical and current images on the making of realities. The task of these books is to present a wide range of research topics that combine historical, material, and critical research approaches that respond to our current crises and challenges. Ultimately, this enables new modes of knowledge production within architecture to be advanced in its relation to societal transformation.With the contributions ofAlberto Altés Arlandis, Mariana Alves, Thordis Arrhenius, Anders Bergström, Luis Berríos-Negrón, Katarina Bonnevier, Brady Burroughs, Ragnhild Claesson, Fran Cottell, Hélène Frichot, Hannes Frykholm, Catharina Gabrielsson, David A. Garcia, Charlotte Geldof, Katja Grillner, Sten Gromark, Sophie Handler, Maria Hellström Reimer, Ben Highmore, Katja Hogenboom, Ebba Högström, Nel Janssens, Mark Jarzombek, Sepideh Karami, Daniel Koch, Thérèse Kristiansson, Mattias Kärrholm, Jennifer Mack, Jesper Magnusson, Helena Mattsson, Marianne Mueller, Katrin Paadam, Christina Pech, Karin Reisinger, Jane Rendell, Helen Runting, Gunnar Sandin, Meike Schalk, Miriam von Schantz, Bettina Schwalm, Erik Sigge, Erik Stenberg, Tijana Stevanović, Apolonija Šušteršič, Roemer van Toorn, Fredrik Torisson
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| 9. |
- Jelenkovic, Aline, et al.
(författare)
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Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age : A Study of the CODATwins Project
- 2015
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Ingår i: Twin Research and Human Genetics. - : Cambridge University Press. - 1832-4274 .- 1839-2628. ; 18:5, s. 557-570
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Tidskriftsartikel (refereegranskat)abstract
- A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m(2) in childhood and adolescence and up to 0.2 kg/m(2) in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.
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