| 1. |
- Rusu, Lazar, et al.
(författare)
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Adding Value to IT Outsourcing Practices in Global Companies: A Case Study of Electrolux
- 2008
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Ingår i: The 9th IBIMA Conference: Information Management in Modern Organizations. - GARDEN CITY PARK : INT BUSINESS INFORMATION MANAGEMENT ASSOC-IBIMA. ; , s. pp. 667-673, s. 667-673
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- In today’s business, organizations seek to optimize the use of their global IT resources therefore IT Outsourcing (ITO) is a tool that enables this optimization, especially when resources with specific competence are needed. The purpose of this paper is to examine what can be learned from best practices regarding ITO in case of Electrolux a Swedish leading global company. We have done that by carrying out a critical analysis of the ITO success factors by analyzing different aspects of ITO in case of Electrolux, and also by using transaction cost economics (TCE). Moreover, in our analysis, we have considered as important factors the outsourcing drivers and models and types of outsourcing that we have identified to have a great impact on the IT outsourcing practices and outcomes.
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| 2. |
- Badawy, Shaimaa Ali, et al.
(författare)
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Multivariate similarity-based conformity measure (MSCM : An outlier detection measure for data mining applications
- 2008
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Ingår i: Proceedings of the IASTED International Conference on Artificial Intelligence and Applications Machine Learning. - Anaheim, Calif : ACTA Press. - 9780889867093 ; , s. 314-320
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Konferensbidrag (refereegranskat)abstract
- Outliers, the odd objects in the dataset, can be viewed from two different perspectives; the outliers as undesirable objects that should be treated or deleted in the data preparation step of the data mining process, and the outliers as interesting objects that are identified for their own interest in the data mining step of the mining process. In the latter case, outliers shouldn't be removed, that's why one of the main categories of tasks performed by data mining techniques is outlier detection. Applications that make use of such detection include credit card fraud detection and network intrusion detection. Most of the available outlier detection techniques rely in a distance measure to compare the objects in the dataset which imposed the restriction of dealing with numeric data. In this paper a new multivariate similarity-based conformity measure (MSCM) is suggested to be used to detect outliers in datasets that contain attributes of different data types. The MSCM satisfies two other desirable features; being a multivariate measure and giving ranking instead of a binary judgment of the object. The measure has been applied on three different datasets in order to be evaluated; the measure has shown good results in these experiments.
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| 3. |
- Issa, Mohamed Mahmoud, 1974-
(författare)
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Linear and Branched Chitosan Oligomers as Delivery Systems for pDNA and siRNA In Vitro and In Vivo
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In this thesis, chitosan, a biocompatible polysaccharide that has been approved as a food additive was selected as a platform for the development of safe, efficient non-viral gene delivery systems to mammalian cells. Previously, chitosan-based gene formulations had been generally associated with high molecular weight chitosans, which were poorly characterised in terms of molecular weight distribution and degree of acetylation. Therefore, in order to improve the properties of chitosan-based gene formulations, the research associated with this thesis focused on establishing the structure-property relationships of well-defined, low molecular weight chitosans (chitosan oligomers) as delivery systems for nucleic acids (pDNA and siRNA) in vitro and after lung administration in vivo. pDNA dissociated more easily from chitosan oligomers than from conventional high molecular weight chitosans, resulting in a faster onset and higher levels of in vivo gene expression, comparable to those mediated by polyethyleneimine (PEI), one of the most efficient non-viral delivery systems. Coupling of a trisaccharide branch to the chitosan oligomers so as to target extracellular lectins resulted in a significant improvement in transfection efficiency because of enhanced cellular uptake and colloidal stability. In contrast to pDNA, longer linear chitosan oligomers were required to form physically-stable nanoparticles with siRNA that mediated efficient, sustained gene silencing in vitro. Finally, the use of an optimised catheter device for the nebulisation of small volumes of pDNA formulations resulted in improved dose precision and lung distribution in vivo compared with conventional intratracheal instillation. In conclusion, chitosan oligomers are interesting and viable alternatives to other non-viral gene delivery systems.
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