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- Maleki, Shohreh, et al.
(författare)
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Identification of a novel flow-mediated gene expression signature in patients with bicuspid aortic valve
- 2013
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Ingår i: Journal of Molecular Medicine. - : Springer-Verlag New York. - 0946-2716 .- 1432-1440. ; 91:1, s. 129-139
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: Individuals with bicuspid aortic valve (BAV) are at significantly higher risk of developing serious aortic complications including aortic aneurysm and dissection than individuals with a tricuspid aortic valve (TAV). Studies have indicated an altered aortic blood flow in patients with BAV, however the extent to which altered flow may influence the pathological state of BAV aorta is still unclear.Objective: To dissect flow-mediated gene expression potentially leading to increased aneurysm susceptibility in patients with BAV.Methods and Results: A large collection of publically available microarray data sets were screened for consistent co-expression with KLF2, KLF4, TIE1, THBD, and PKD2, five previously well-characterized flow-regulated genes. This identified 122 genes with coexpression probability of >0.5. Of these, 44 genes satisfied two additional filtering criteria in ascending aorta (127 arrays). The criteria were significant correlation with one or more of the 5 query genes (R>0.40) and differential expression between patients with BAV and TAV. No gene fulfilled the criteria in mammary artery (88 arrays). A large proportion of the identified genes were angiogenesis related genes. Further, 55% of the genes differentially expressed between BAV and TAV showed differential expression in disturbed vs. uniform flow pattern regions in rat aorta. Protein expression of ZFP36, PKD2 and GPR116 were analyzed by immunohistochemistry and their association with BAV were further discussed.Conclusions: With a new strategy to dissect flow-mediated gene expression, we identified novel genes associated with valve morphology. The complex pattern of blood flow, as a consequence of BAV
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- Maleki, S., et al.
(författare)
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Power allocation for energy-constrained cognitive radios in the presence of an eavesdropper
- 2014
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Ingår i: 2014 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP). - : IEEE conference proceedings. ; , s. 5695-5699
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Konferensbidrag (refereegranskat)abstract
- Reliable and agile spectrum sensing as well as secure communication are key requirements of a cognitive radio system. In this paper, secrecy throughput of a cognitive radio is maximized in order to determine the sensing threshold, the sensing time, and the transmission power. Constraints of the problem are defined as a lower-bound on the detection probability, an upper-bound on the average energy consumption per time-frame, and the maximum transmission power of the cognitive radio. We show that the problem can be solved by an on-off strategy where the cognitive radio only performs sensing and transmits data if the cognitive channel gain is greater than the average eavesdropper channel gain. The problem is then solved by a line-search over sensing time. Eventually, the secrecy throughput of the cognitive radio is evaluated employing the IEEE 802.15.4/Zig-Bee standard.
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- Maleki, V., et al.
(författare)
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Earthquake relocation in the Central Alborz region of Iran using a non-linear probabilistic method
- 2013
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Ingår i: Journal of Seismology. - : Springer Science and Business Media LLC. - 1383-4649 .- 1573-157X. ; 17:2, s. 615-628
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we calculate accurate absolutelocations for nearly 3,000 shallow earthquakes(≤20 km depth) that occurred from 1996 to 2010 inthe Central Alborz region of northern Iran using a nonlinearprobabilistic relocation algorithm on a localscale. We aim to produce a consistent dataset with arealistic assessment of location errors using probabilistichypocenter probability density functions. Ourresults indicate significant improvement in hypocenterlocations and far less scattering than in the routineearthquake catalog. According to our results, 816earthquakes have horizontal uncertainties in the 0.5–3.0 km range, and 981 earthquakes are relocated withfocal-depth errors less than 3.0 km, even with a suboptimalnetwork geometry. Earthquake relocated aretightly clustered in the eastern Tehran region and aremainly associated with active faults in the study area(the Mosha and Garmsar faults). Strong historicalearthquakes have occurred along the Mosha andGarmsar faults, and the relocated earthquakes alongthese faults show clear north-dipping structures andalign along east–west lineations, consistent with thepredominant trend of faults within the study region.After event relocation, all seismicity lies in the upper20 km of the crust, and no deep seismicity (>20 kmdepth) has been observed. In many circumstances, theseismicity at depth does not correlate with surfacefaulting, suggesting that the faulting at depth doesnot directly offset overlying sediments.
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