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- Arctaedius, Isabelle, et al.
(författare)
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Plasma glial fibrillary acidic protein and tau: predictors of neurological outcome after cardiac arrest.
- 2024
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Ingår i: Critical care (London, England). - 1466-609X. ; 28:1
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Tidskriftsartikel (refereegranskat)abstract
- The purpose was to evaluate glial fibrillary acidic protein (GFAP) and total-tau in plasma as predictors of poor neurological outcome after out-of-hospital (OHCA) and in-hospital cardiac arrest (IHCA), including comparisons with neurofilament light (NFL) and neuron-specific enolase (NSE).Retrospective multicentre observational study of patients admitted to an intensive care unit (ICU) in three hospitals in Sweden 2014-2018. Blood samples were collected at ICU admission, 12h, and 48h post-cardiac arrest. Poor neurological outcome was defined as Cerebral Performance Category 3-5 at 2-6months after cardiac arrest. Plasma samples were retrospectively analysed for GFAP, tau, and NFL. Serum NSE was analysed in clinical care. Prognostic performances were tested with the area under the receiver operating characteristics curve (AUC).Of the 428 included patients, 328 were OHCA, and 100 were IHCA. At ICU admission, 12h and 48h post-cardiac arrest, GFAP predicted neurological outcome after OHCA with AUC (95% CI) 0.76 (0.70-0.82), 0.86 (0.81-0.90) and 0.91 (0.87-0.96), and after IHCA with AUC (95% CI) 0.77 (0.66-0.87), 0.83 (0.74-0.92) and 0.83 (0.71-0.95). At the same time points, tau predicted outcome after OHCA with AUC (95% CI) 0.72 (0.66-0.79), 0.75 (0.69-0.81), and 0.93 (0.89-0.96) and after IHCA with AUC (95% CI) 0.61 (0.49-0.74), 0.68 (0.56-0.79), and 0.77 (0.65-0.90). Adding the change in biomarker levels between time points did not improve predictive accuracy compared to the last time point. In a subset of patients, GFAP at 12h and 48 h, as well as tau at 48h, offered similar predictive value as NSE at 48h (the earliest time point NSE is recommended in guidelines) after both OHCA and IHCA. The predictive performance of NFL was similar or superior to GFAP and tau at all time points after OHCA and IHCA.GFAP and tau are promising biomarkers for neuroprognostication, with the highest predictive performance at 48h after OHCA, but not superior to NFL. The predictive ability of GFAP may be sufficiently high for clinical use at 12h after cardiac arrest.
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- Berg, Gita, 1982-, et al.
(författare)
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“You fuel the car with gas, you fuel the body with food” –Educational functions of food for health in home and consumer studies
- 2022
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Ingår i: Scandinavian Journal of Educational Research. - : Taylor & Francis. - 0031-3831 .- 1470-1170. ; , s. 1-15
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Tidskriftsartikel (refereegranskat)abstract
- This study aims to contribute to the understanding of food for health as educational content in Home and Consumer Studies (HCS), specifically targeting three educational functions: (i) qualification, (ii) socialization, and (iii) subjectification. Data came from a comprehensive case study, where one school class and two HCS teachers were followed during one school year. Fourteen classroom observations and eight teacher interviews were included. It is shown how qualification functions comprise nutrition knowledge and cooking skills, how socialization functions entail, e.g., dichotomous values of food as “good” or “bad,” and how conscious consumers who take personal responsibility for themselves and the environment become promoted subjects. Taken together, the results illustrate how educational content can have consequences beyond those intended. Based on the results, an argument is made about the relevance for HCS teachers to critically reflect on their teaching and its potential educational consequences.
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- Boric, Bojan
(författare)
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The Ghost Boulevard
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In 1947, Soviet architect Alexey Shchusev developed a large-scale urban renewal project for the post-war city of Chisinau, the then-capital of the SSR of Moldova. Part of the master plan was the construction of Boulevard D. Cantemir, which would cut through the city’s historic fabric. Only two sections of the boulevard were built before the project was abandoned. During the period of radical institutional political and economic shift towards a market economy in the early 1990s, initiatives to build the boulevard re-emerged through red lines, zoning documents, and planning regulations. The lack of political consensus caused planning paralyses over the city, creating a legal void where different actors competed to appropriate spaces. The power of the red lines has prompted various kinds of materializations of the boulevard. The real battle takes place in the sphere of the imaginary, and memory management is one of the main planning tools. Exploring the trajectory of the “Ghost Boulevard,” I reveal conflicting political and economic agendas and the many forces that constitute complex processes of planning today.
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- Brolund de Carvalho, Sara, Adjunkt, 1974-, et al.
(författare)
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‘You can simply say no’ : Narrating the effects and affects of Danish and Swedish housing in crisis
- 2024
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Ingår i: Radical Housing Journal. - : Radical Housing Journal. - 2632-2870. ; 6:1, s. 201-219
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Tidskriftsartikel (refereegranskat)abstract
- Narratives about the ‘failure’ of large-scale post-World War II housing are now guiding major physical, social, and economic changes in neighborhoods all over Europe. This is true even in Denmark and Sweden, which have long been known for their welfare states and benevolent housing policies. Today, however, both countries have enacted new national anti-segregation measures that call for major physical and social changes to neighborhoods built in the postwar era, even as the opinions of local communities and residents of such neighborhoods have been only sparsely heard – if at all. By working with the method ‘witness seminars’, we – as the research collective Aktion Arkiv – foreground residents’ perspectives and their collective resistance: the effects and affects of top-down changes. While sharing their lived experiences and actions, residents say that architects and planners can ‘simply say no’ and thereby refuse to participate in these actions.
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- Elfving, Hedvig, et al.
(författare)
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Evaluation of NTRK immunohistochemistry as a screening method for NTRK gene fusion detection in non-small cell lung cancer
- 2021
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Ingår i: Lung Cancer. - : Elsevier. - 0169-5002 .- 1872-8332. ; 151, s. 53-59
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The small molecule inhibitors larotrectinib and entrectinib have recently been approved as cancer agnostic drugs in patients with tumours harbouring a rearrangement of the neurotrophic tropomyosin receptor kinase (NTRK). These oncogenic fusions are estimated to occur in 0.1-3 % of non-small cell lung cancers (NSCLC). Although molecular techniques are most reliable for fusion detection, immunohistochemical analysis is considered valuable for screening. Therefore, we evaluated the newly introduced diagnostic immunohistochemical assay (clone EPR17341) on a representative NSCLC cohort.Methods: Cancer tissue from 688 clinically and molecularly extensively annotated NSCLC patients were comprised on tissue microarrays and stained with the pan-TRK antibody clone EPR17341. Positive cases were further analysed with the TruSight Tumor 170 RNA assay (Illumina). Selected cases were also tested with a NanoString NTRK fusion assay. For 199 cases, NTRK RNA expression data were available from previous RNA sequencing analysis.Results: Altogether, staining patterns for 617 NSCLC cases were evaluable. Of these, four cases (0.6 %) demonstrated a strong diffuse cytoplasmic and membranous staining, and seven cases a moderate staining (1.1 %). NanoString or TST170-analysis could not confirm an NTRK fusion in any of the IHC positive cases, or any of the cases with high mRNA levels. In the four cases with strong staining intensity in the tissue microarray, whole section staining revealed marked heterogeneity of NTRK protein expression.Conclusion: The presence of NTRK fusion genes in non-small cell lung cancer is exceedingly rare. The use of the immunohistochemical NTRK assay will result in a small number of false positive cases. This should be considered when the assay is applied as a screening tool in clinical diagnostics.
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- Forslund, Helena, 1964-, et al.
(författare)
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In search of supplier flexibility performance measurement
- 2023
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Ingår i: International Journal of Productivity and Performance Management. - : Emerald Group Publishing Limited. - 1741-0401 .- 1758-6658. ; 72:3, s. 772-788
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Tidskriftsartikel (refereegranskat)abstract
- Purpose The purpose of this study is to identify, characterize and assess supplier flexibility measurement practices in the order-to-delivery process. Design/methodology/approach The study involved a survey; participants were 224 purchasing managers at Swedish manufacturing companies that had more than 20 employees. Findings Scrutiny of the details of measurement practices revealed that most respondents actually do not specifically measure supplier flexibility. Instead they measure other measures like delivery reliability, conduct qualitative follow-ups, or cannot specify how supplier flexibility is measured. It was acknowledged that they measure different supplier flexibility aspects, and the applied measures were characterized, e.g. in terms of which flexibility dimension they represent. Research limitations/implications Conceptual clarifications and adaptations to measuring supplier flexibility in the order-to-delivery process are provided. The identified measures can be a contribution in further developing literature on flexibility performance measurement. Practical implications Purchasing, logistics and supply chain managers in search of supplier flexibility performance measurement can find ways to measure and an extended flexibility vocabulary. This has the potential to improve flexibility in the supply chain. Originality/value Even though flexibility is claimed as being an important competitive advantage, few empirical studies and operationalized measures exist, particularly in the order-to-delivery process.
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