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Träfflista för sökning "WFRF:(Muller H) srt2:(1995-1999)"

Sökning: WFRF:(Muller H) > (1995-1999)

  • Resultat 1-10 av 19
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  • Olofsson, A M, et al. (författare)
  • Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis
  • 1999
  • Ingår i: Journal of Clinical Investigation. - 0021-9738. ; 104:7, s. 885-894
  • Tidskriftsartikel (refereegranskat)abstract
    • Neutrophil-borne heparin-binding protein (HBP) is a multifunctional protein involved in the progression of inflammation. HBP is stored in neutrophil granules and released upon stimulation of the cells in proximity to endothelial cells. HBP affects endothelial cells in multiple ways; however, the molecular and cellular mechanisms underlying the interaction of HBP with these cells are unknown. Affinity isolation and enzymatic degradation demonstrated that HBP released from human neutrophils binds to endothelial cell-surface proteoglycans, such as syndecans and glypican. Flow cytometry indicated that a significant fraction of proteoglycan-bound HBP is taken up by the endothelial cells, and we used radiolabeled HBP to determine the internalization rate of surface-bound HBP. Confocal and electron microscopy revealed that internalized HBP is targeted to perinuclear compartments of endothelial cells, where it colocalizes with mitochondria. Western blotting of isolated mitochondria from HBP-treated endothelial cells showed that HBP is present in 2 forms - 28 and 22 kDa. Internalized HBP markedly reduced growth factor deprivation-induced caspase-3 activation and protected endothelial cells from apoptosis, suggesting that uptake and intracellular routing of exogenous HBP to mitochondria contributes to the sustained viability of endothelial cells in the context of locally activated neutrophils.
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  • Anger, S, et al. (författare)
  • High resolution size determination of 20 nm colloidal gold particles by SedFFF
  • 1999
  • Ingår i: PHARMACEUTICAL RESEARCH. - : KLUWER ACADEMIC/PLENUM PUBL. - 0724-8741. ; 16:11, s. 1743-1747
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Purpose. Assessment of lower size limit of Sedimentation Field-Flow Fractionation (SedFFF), specifically to evaluate if the method is suitable to determine the size and size distribution of 20 nm colloidal gold particles with high resolution. Methods. Sed
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  • Engelmann, U, et al. (författare)
  • Experiences with the German teleradiology system MEDICUS
  • 1997
  • Ingår i: COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE. - 0169-2607. ; 54:1-2, s. 131-139
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • This paper introduces the teleradiology system, MEDICUS, which has been developed at the Deutsches Krebsforschungszentrum (German Cancer Research Center) in Heidelberg, Germany. The system is designed to work on ISDN lines as well as in a local area netwo
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  • Engelmann U. Schröter A, Baur U, Werner O, Göransson B, Borälv E, Schwab M, Müller H, Bahner M, Meinzer HP. (författare)
  • Experiences with the German teleradiology system MEDICUS
  • 1998
  • Ingår i: Yearbook of Medical Informatics '98 - Health Informatics and the Internet. - : Stuttgart: Schattauer. ; , s. 199-207
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Resultat 1-10 av 19

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