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Putative targeting ...
Putative targeting by BX795 causes decrease in protein kinase C protein levels and inhibition of HSV1 infection
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- Suryawanshi, Rahul K. (författare)
- Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
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- Patil, Chandrashekhar D. (författare)
- Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
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- Wu, David (författare)
- Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
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- Panda, Pritam Kumar, PhD Student, 1991- (författare)
- Uppsala universitet,Materialteori
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- Singh, Sudhanshu Kumar (författare)
- Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.
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- Volety, Ipsita (författare)
- Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA.
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- Ahuja, Rajeev, 1965- (författare)
- Uppsala universitet,Materialteori,Indian Inst Technol Ropar, Dept Phys, Rupnagar 140001, Punjab, India.
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- Mishra, Yogendra Kumar (författare)
- Univ Southern Denmark, NanoSYD, Mads Clausen Inst, Als 2, DK-6400 Alsion, Denmark.
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- Shukla, Deepak (författare)
- Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA.;Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA.
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Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA Materialteori (creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Antiviral Research. - : Elsevier. - 0166-3542 .- 1872-9096. ; 208
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Herpes simplex virus type-1 (HSV1) exploits cellular machinery for its own replicative advantage. Current treatment modalities against HSV1 cause toxicity and drug resistance issues. In the search for alternative forms of treatment, we have uncovered a small molecule, BX795, as a candidate drug with strong antiviral potential owing to its multitargeted mode of action. In this study, we show that in addition to a previously known mechanism of action, BX795 can directly interact with the proviral host factor protein kinase C (PKC) in silico. When administered to HSV1 or mock infected human corneal epithelial (HCE) cells, BX795 significantly reduces the protein level and perinuclear localization of proviral PKC-alpha and PKC-zeta isoforms. This activity closely mimics that of a known PKC inhibitor, Bisindolylmaleimide I (BIM I), which also inhibits viral replication. Taken together our studies demonstrate a previously unknown mechanism by which BX795 exerts its antiviral potential.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Herpesvirus
- BX795
- Antiviral
- Mechanism
- Protein kinase C
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Suryawanshi, Rah ...
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Patil, Chandrash ...
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Wu, David
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Panda, Pritam Ku ...
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Singh, Sudhanshu ...
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Volety, Ipsita
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visa fler...
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Ahuja, Rajeev, 1 ...
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Mishra, Yogendra ...
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Shukla, Deepak
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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Antiviral Resear ...
- Av lärosätet
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Uppsala universitet