| 1. |
- Thomas, HS, et al.
(författare)
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- 2019
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swepub:Mat__t
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| 2. |
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| 3. |
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| 4. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Ujan, Rabail, et al.
(författare)
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Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase : Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation
- 2019
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Ingår i: Molecules. - : MDPI. - 1431-5157 .- 1420-3049. ; 24:5
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Tidskriftsartikel (refereegranskat)abstract
- A small library of new drug-1,3,4-thiazidazole hybrid compounds (3a-3i) was synthesized, characterized, and assessed for their acetyl cholinesterase enzyme (AChE) inhibitory and free radical scavenging activities. The newly synthesized derivatives showed promising activities against AChE, especially compound 3b (IC50 18.1 +/- 0.9 nM), which was the most promising molecule in the series, and was substantially more active than the reference drug (neostigmine methyl sulfate; IC50 2186.5 +/- 98.0 nM). Kinetic studies were performed to elucidate the mode of inhibition of the enzyme, and the compounds showed mixed-type mechanisms for inhibiting AChE. The Ki of 3b (0.0031 mu M) indicates that it can be very effective, even at low concentrations. Compounds 3a-3i all complied with Lipinski's Rule of Five, and showed high drug-likeness scores. The pharmacokinetic parameters revealed notable lead-like properties with insignificant liver and skin-penetrating effects. The structure-activity relationship (SAR) analysis indicated pi-pi interactions with key amino acid residues related to Tyr124, Trp286, and Tyr341.
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| 6. |
- Irshad, Muneeb, et al.
(författare)
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A Brief Description of High Temperature Solid Oxide Fuel Cell's Operation, Materials, Design, Fabrication Technologies and Performance
- 2016
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Ingår i: Applied Sciences. - : MDPI AG. - 2076-3417. ; 6:3
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Forskningsöversikt (refereegranskat)abstract
- Today's world needs highly efficient systems that can fulfill the growing demand for energy. One of the promising solutions is the fuel cell. Solid oxide fuel cell (SOFC) is considered by many developed countries as an alternative solution of energy in near future. A lot of efforts have been made during last decade to make it commercial by reducing its cost and increasing its durability. Different materials, designs and fabrication technologies have been developed and tested to make it more cost effective and stable. This article is focused on the advancements made in the field of high temperature SOFC. High temperature SOFC does not need any precious catalyst for its operation, unlike in other types of fuel cell. Different conventional and innovative materials have been discussed along with properties and effects on the performance of SOFC's components (electrolyte anode, cathode, interconnect and sealing materials). Advancements made in the field of cell and stack design are also explored along with hurdles coming in their fabrication and performance. This article also gives an overview of methods required for the fabrication of different components of SOFC. The flexibility of SOFC in terms fuel has also been discussed. Performance of the SOFC with varying combination of electrolyte, anode, cathode and fuel is also described in this article.
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| 7. |
- Mugheri, Abdul Qayoom, et al.
(författare)
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An advanced and efficient Co3O4/C nanocomposite for the oxygen evolution reaction in alkaline media
- 2019
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Ingår i: RSC Advances. - : Royal Society of Chemistry. - 2046-2069. ; 9:59, s. 34136-34143
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Tidskriftsartikel (refereegranskat)abstract
- The design of efficient nonprecious catalysts for the hydrogen evolution reaction (HER) or the oxygen evolution reaction (OER) is a necessary, but very challenging task to uplift the water-based economy. In this study, we developed a facile approach to produce porous carbon from the dehydration of sucrose and use it for the preparation of nanocomposites with cobalt oxide (Co3O4). The nanocomposites were studied by the powder X-ray diffraction and scanning electron microscopy techniques, and they exhibited the cubic phase of cobalt oxide and porous structure of carbon. The nanocomposites showed significant OER activity in alkaline media, and the current densities of 10 and 20 mA cm(-2) could be obtained at 1.49 and 1.51 V versus reversible hydrogen electrode (RHE), respectively. The impedance study confirms favorable OER activity on the surface of the prepared nanocomposites. The nanocomposite is cost-effective and can be capitalized in various energy storage technologies.
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| 8. |
- Shahzad, Danish, et al.
(författare)
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Novel C-2 Symmetric Molecules as -Glucosidase and -Amylase Inhibitors : Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics
- 2019
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Ingår i: Molecules. - : MDPI. - 1431-5157 .- 1420-3049. ; 24:8
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Tidskriftsartikel (refereegranskat)abstract
- A series of symmetrical salicylaldehyde-bishydrazine azo molecules, 5a-5h, have been synthesized, characterized by H-1-NMR and C-13-NMR, and evaluated for their in vitro -glucosidase and -amylase inhibitory activities. All the synthesized compounds efficiently inhibited both enzymes. Compound 5g was the most potent derivative in the series, and powerfully inhibited both -glucosidase and -amylase. The IC50 of 5g against -glucosidase was 0.35917 +/- 0.0189 mu M (standard acarbose IC50 = 6.109 +/- 0.329 mu M), and the IC50 value of 5g against -amylase was 0.4379 +/- 0.0423 mu M (standard acarbose IC50 = 33.178 +/- 2.392 mu M). The Lineweaver-Burk plot indicated that compound 5g is a competitive inhibitor of -glucosidase. The binding interactions of the most active analogues were confirmed through molecular docking studies. Docking studies showed that 5g interacts with the residues Trp690, Asp548, Arg425, and Glu426, which form hydrogen bonds to 5g with distances of 2.05, 2.20, 2.10 and 2.18 angstrom, respectively. All compounds showed high mutagenic and tumorigenic behaviors, and only 5e showed irritant properties. In addition, all the derivatives showed good antioxidant activities. The pharmacokinetic evaluation also revealed promising results
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| 9. |
- Zeb, Shah, et al.
(författare)
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NOMA Enhanced Backscatter Communication for Green IoT Networks
- 2019
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Ingår i: 16th International Symposium on Wireless Communication Systems (ISWCS). - : VDE Verlag GmbH. ; , s. 640-644
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Konferensbidrag (refereegranskat)abstract
- Backscatter communication has recently emerged as a promising technology to enable passive sensing-based Internet-of-things (IoT) applications. In a backscatter communication network, uplink transmissions of multiple nodes are usually multiplexed in time- or frequency-domain to avoid collisions, yet it is desirable to improve the uplink capacity further. In this paper, we study a wireless-powered backscatter communication system, where the sensors use a hybrid channel access scheme by combining time division multiplexing access(TDMA) with power-domain non-orthogonal multiple access(PD-NOMA) to enhance the system performance in terms of outage probability and throughput. Our analysis shows that the proposed PD-NOMA increases both the spectrum efficiency and the throughput of the system.
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| 10. |
- Abas, Naeem, et al.
(författare)
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Dynamic simulation of solar water heating system using supercritical CO2 as mediating fluid under sub-zero temperature conditions
- 2019
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Ingår i: Applied Thermal Engineering. - Oxford, UK : Pergamon Press. - 1359-4311 .- 1873-5606. ; 161
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Tidskriftsartikel (refereegranskat)abstract
- CO2 is becoming increasingly important as a mediating fluid, and simulation studies are indispensable for corresponding developments. In this study, a simulation-based performance investigation of a solar water heating system using CO2 as a mediating fluid under sub-zero temperature condition is performed using the TRNSYS (R) software. The maximum performance is achieved at a solar savings fraction of 0.83 during July. The as lowest solar savingss fraction of 0.41 is obtained during December. The annual heat production of the proposed system under Fargo climate is estimated to be about 2545 kWh. An evacuated glass tube solar collector is designed, fabricated and tested for various climate conditions. Moreover, a detailed comparison of the system's performance at sub/supercritical and supercritical pressures shows that the annual heat transfer efficiency of the modeled system is 10% higher at supercritical pressure than at sub/supercritical pressures. This result can be attributd to the strong convection flow of CO2 caused by density inhomogeneities, especially in the near critical region. This condition resuls in high heat transfer rates.
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