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- Barbui, Tiziano, et al.
(författare)
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Philadelphia-Negative Classical Myeloproliferative Neoplasms : Critical Concepts and Management Recommendations From European LeukemiaNet
- 2011
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Ingår i: Journal of Clinical Oncology. - 0732-183X .- 1527-7755. ; 29:6, s. 761-770
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Tidskriftsartikel (refereegranskat)abstract
- We present a review of critical concepts and produce recommendations on the management of Philadelphia-negative classical myeloproliferative neoplasms, including monitoring, response definition, first-and second-line therapy, and therapy for special issues. Key questions were selected according the criterion of clinical relevance. Statements were produced using a Delphi process, and two consensus conferences involving a panel of 21 experts appointed by the European LeukemiaNet (ELN) were convened. Patients with polycythemia vera (PV) and essential thrombocythemia (ET) should be defined as high risk if age is greater than 60 years or there is a history of previous thrombosis. Risk stratification in primary myelofibrosis (PMF) should start with the International Prognostic Scoring System (IPSS) for newly diagnosed patients and dynamic IPSS for patients being seen during their disease course, with the addition of cytogenetics evaluation and transfusion status. High-risk patients with PV should be managed with phlebotomy, low-dose aspirin, and cytoreduction, with either hydroxyurea or interferon at any age. High-risk patients with ET should be managed with cytoreduction, using hydroxyurea at any age. Monitoring response in PV and ET should use the ELN clinicohematologic criteria. Corticosteroids, androgens, erythropoiesis-stimulating agents, and immunomodulators are recommended to treat anemia of PMF, whereas hydroxyurea is the first-line treatment of PMF-associated splenomegaly. Indications for splenectomy include symptomatic portal hypertension, drug-refractory painful splenomegaly, and frequent RBC transfusions. The risk of allogeneic stem-cell transplantation-related complications is justified in transplantation-eligible patients whose median survival time is expected to be less than 5 years.
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- Calves, G. M., et al.
(författare)
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Observations and analysis of phase scintillation of spacecraft signal on the interplanetary plasma
- 2014
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 564
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Tidskriftsartikel (refereegranskat)abstract
- Aims. The phase scintillation of the European Space Agency's Venus Express (VEX) spacecraft telemetry signal was observed at X-band (lambda = 3.6 cm) with a number of radio telescopes of the European Very Long Baseline Interferometry (VLBI) Network in the period 2009-2013. Methods. We found a phase fluctuation spectrum along the Venus orbit with a nearly constant spectral index of -2.42 +/- 0.25 over the full range of solar elongation angles from 0 degrees to 45 degrees, which is consistent with Kolmogorov turbulence. Radio astronomical observations of spacecraft signals within the solar system give a unique opportunity to study the temporal behaviour of the signal's phase fluctuations caused by its propagation through the interplanetary plasma and the Earth's ionosphere. This gives complementary data to the classical interplanetary scintillation (IPS) study based on observations of the flux variability of distant natural radio sources. Results. We present here our technique and the results on IPS. We compare these with the total electron content for the line of sight through the solar wind. Finally, we evaluate the applicability of the presented technique to phase-referencing VLBI and Doppler observations of currently operational and prospective space missions.
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- Rieck, Carsten, 1972, et al.
(författare)
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VLBI time-transfer using CONT08 data
- 2010
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Ingår i: Proceedings of the 24th European Frequency and Time Forum ESA/ESTEC Noordwijk (NL) 13-16 April 2010. - 9781467359702
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- One important prerequisite for geodetic Very Long Baseline Interferometry (VLBI) is the use of frequency standards with excellent short term stability, i.e. hydrogen masers. This makes VLBI stations, which are often co-located with Global Navigation Satellite System (GNSS) receiving stations, interesting for studies of time- and frequency-transfer techniques. In this paper we present an assessment of VLBI time-transfer based on the data of the two week long consecutive IVS Cont08 VLBI-campaign by using GPS Carrier Phase (GPSCP). Cont08 was a 15 days long campaign in August 2008 that involved eleven VLBI stations on five continents. For Cont08 we estimated the worst case VLBI time link stability between the station clocks of ONSALA and WETTZELL to about 1.5e-15 at one day. Comparisons with clock differences estimated with GPSCP confirm the VLBI results. The paper also indicates time-transfer related problems of the VLBI technique as used today. © 2010 IEEE.
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- Teke, K., et al.
(författare)
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Multi-technique comparison of troposphere zenith delays and gradients during CONT08
- 2011
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Ingår i: Journal of Geodesy. - : Springer Science and Business Media LLC. - 0949-7714 .- 1432-1394. ; 85:7, s. 395-413
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Tidskriftsartikel (refereegranskat)abstract
- CONT08 was a 15 days campaign of continuous Very Long Baseline Interferometry (VLBI) sessions during the second half of August 2008 carried out by the International VLBI Service for Geodesy and Astrometry (IVS). In this study, VLBI estimates of troposphere zenith total delays (ZTD) and gradients during CONT08 were compared with those derived from observations with the Global Positioning System (GPS), Doppler Orbitography and Radiopositioning Integrated by Satellite (DORIS), and water vapor radiometers (WVR) co-located with the VLBI radio telescopes. Similar geophysical models were used for the analysis of the space geodetic data, whereas the parameterization for the least-squares adjustment of the space geodetic techniques was optimized for each technique. In addition to space geodetic techniques and WVR, ZTD and gradients from numerical weather models (NWM) were used from the European Centre for Medium-Range Weather Forecasts (ECMWF) (all sites), the Japan Meteorological Agency (JMA) and Cloud Resolving Storm Simulator (CReSS) (Tsukuba), and the High Resolution Limited Area Model (HIRLAM) (European sites). Biases, standard deviations, and correlation coefficients were computed between the troposphere estimates of the various techniques for all eleven CONT08 co-located sites. ZTD from space geodetic techniques generally agree at the sub-centimetre level during CONT08, and-as expected-the best agreement is found for intra-technique comparisons: between the Vienna VLBI Software and the combined IVS solutions as well as between the Center for Orbit Determination (CODE) solution and an IGS PPP time series; both intra-technique comparisons are with standard deviations of about 3-6 mm. The best inter space geodetic technique agreement of ZTD during CONT08 is found between the combined IVS and the IGS solutions with a mean standard deviation of about 6 mm over all sites, whereas the agreement with numerical weather models is between 6 and 20 mm. The standard deviations are generally larger at low latitude sites because of higher humidity, and the latter is also the reason why the standard deviations are larger at northern hemisphere stations during CONT08 in comparison to CONT02 which was observed in October 2002. The assessment of the troposphere gradients from the different techniques is not as clear because of different time intervals, different estimation properties, or different observables. However, the best inter-technique agreement is found between the IVS combined gradients and the GPS solutions with standard deviations between 0.2 and 0.7 mm.
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