| 1. |
- Baughn, Linda B., et al.
(författare)
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Targeting TMPRSS2 in SARS-CoV-2 Infection
- 2020
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Ingår i: Mayo Clinic Proceedings. - : Elsevier BV. - 0025-6196. ; 95:9, s. 1989-1999
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Tidskriftsartikel (refereegranskat)abstract
- Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has rapidly caused a global pandemic associated with a novel respiratory infection: coronavirus disease-19 (COVID-19). Angiotensin-converting enzyme-2 (ACE2) is necessary to facilitate SARS-CoV-2 infection, but—owing to its essential metabolic roles—it may be difficult to target it in therapies. Transmembrane protease serine 2 (TMPRSS2), which interacts with ACE2, may be a better candidate for targeted therapies. Using publicly available expression data, we show that both ACE2 and TMPRSS2 are expressed in many host tissues, including lung. The highest expression of ACE2 is found in the testes, whereas the prostate displays the highest expression of TMPRSS2. Given the increased severity of disease among older men with SARS-CoV-2 infection, we address the potential roles of ACE2 and TMPRSS2 in their contribution to the sex differences in severity of disease. We show that expression levels of ACE2 and TMPRSS2 are overall comparable between men and women in multiple tissues, suggesting that differences in the expression levels of TMPRSS2 and ACE2 in the lung and other non–sex-specific tissues may not explain the gender disparities in severity of SARS CoV-2. However, given their instrumental roles for SARS-CoV-2 infection and their pleiotropic expression, targeting the activity and expression levels of TMPRSS2 is a rational approach to treat COVID-19.
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| 2. |
- Johannsen, Emma B., et al.
(författare)
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The genetics of sudden infant death syndrome—towards a gene reference resource
- 2021
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Ingår i: Genes. - : MDPI AG. - 2073-4425. ; 12:2
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Tidskriftsartikel (refereegranskat)abstract
- Sudden infant death syndrome (SIDS) is the unexpected death of an infant under one year of age that remains unexplained after a thorough investigation. Despite SIDS remaining a diagnosis of exclusion with an unexplained etiology, it is widely accepted that SIDS can be caused by environmental and/or biological factors, with multiple underlying candidate genes. However, the lack of biomarkers raises questions as to why genetic studies on SIDS to date are unable to provide a clearer understanding of the disease etiology. We sought to improve the identification of SIDS-associated genes by reviewing the SIDS genetic literature and objectively categorizing and scoring the reported genes based on the strength of evidence (from C1 (high) to C5 (low)). This was followed by analyses of function, associations between genes, the enrichment of gene ontology (GO) terms, and pathways and gender difference in tissue gene expression. We constructed a curated database for SIDS gene candidates consisting of 109 genes, 14 of which received a category 4 (C4) and 95 genes received the lowest category of C5. That none of the genes was classified into the higher categories indicates the low level of supporting evidence. We found that genes of both scoring categories show distinct networks and are highly diverse in function and involved in many GO terms and pathways, in agreement with the perception of SIDS as a heterogeneous syndrome. Genes of both scoring categories are part of the cardiac system, muscle, and ion channels, whereas immune-related functions showed enrichment for C4 genes. A limited association was found with neural development. Overall, inconsistent reports and missing metadata contribute to the ambiguity of genetic studies. Considering those parameters could help improve the identification of at-risk SIDS genes. However, the field is still far from offering a full-pledged genetic test to identify at-risk infants and is still hampered with methodological challenges and misunderstandings of the vulnerabilities of vital biological mechanisms.
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| 3. |
- Kim, Eun Jeong, et al.
(författare)
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Importance of Superstructure in Stabilizing Oxygen Redox in P3-Na0.67Li0.2Mn0.8O2
- 2022
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Ingår i: Advanced Energy Materials. - : John Wiley & Sons. - 1614-6832 .- 1614-6840. ; 12:3
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Tidskriftsartikel (refereegranskat)abstract
- Activation of oxygen redox represents a promising strategy to enhance the energy density of positive electrode materials in both lithium and sodium-ion batteries. However, the large voltage hysteresis associated with oxidation of oxygen anions during the first charge represents a significant challenge. Here, P3-type Na0.67Li0.2Mn0.8O2 is reinvestigated and a ribbon superlattice is identified for the first time in P3-type materials. The ribbon superstructure is maintained over cycling with very minor unit cell volume changes in the bulk while Li ions migrate reversibly between the transition metal and Na layers at the atomic scale. In addition, a range of spectroscopic techniques reveal that a strongly hybridized Mn 3d-O 2p favors ligand-to-metal charge transfer, also described as a reductive coupling mechanism, to stabilize reversible oxygen redox. By preparing materials under three different synthetic conditions, the degree of ordering between Li and Mn is varied. The sample with the maximum cation ordering delivers the largest capacity regardless of the voltage windows applied. These findings highlight the importance of cationic ordering in the transition metal layers, which can be tuned by synthetic control to enhance anionic redox and hence energy density in rechargeable batteries.
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| 4. |
- Kumar, Dhirender, et al.
(författare)
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Population Dynamics of Juniperus macropoda Bossier Forest Ecosystem in Relation to Soil Physico-Chemical Characteristics in the Cold Desert of North-Western Himalaya
- 2022
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Ingår i: Forests. - : MDPI. - 1999-4907 .- 1999-4907. ; 13:10
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Tidskriftsartikel (refereegranskat)abstract
- Juniperus macropoda is the only tree species of a cold desert ecosystem that is experiencing high anthropogenic pressure and has a poor regeneration status due to harsh environmental conditions. Due to the limited distribution of Juniperus macropoda in this region, the species have remained largely unexplored in terms of understanding the distribution pattern along the elevation and soil fertility gradients. Therefore, the current research was carried out along the elevational gradient, starting from the base line at 3000 m above sea level (m asl) asl with an elevational plot distance of 180 m. The study revealed that the average density of J. macropoda declined gradually from the first elevation range, i.e., 3000–3180 m asl onward, and extended up to the elevation range of 3900–4080 m asl. However, the average seedling and sapling densities were highest at mid-elevation and extended up to an elevation range of 4080–4260 m asl. The J. macropoda population formed a reverse J-shaped structure only up to 3540–3720 m asl. The maximum total biomass and carbon density were recorded in the lowest elevational range, and decreased subsequently. The primary soil nutrients under study decreased sharply along the elevational gradient. Seedling, sapling and tree distributions had a significantly positive relationship (p < 0.05) with available N, P, K, SOC, silt and clay contents and were negatively correlated (p < 0.05) with sand contents. The outcome of the study will form the basis for devising a plan for the management and conservation of J. macropoda forests.
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| 5. |
- Neeraj, Kumar, 1991-, et al.
(författare)
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Terahertz charge and spin transport in metallic ferromagnets : The role of crystalline and magnetic order
- 2022
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 120:10
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Tidskriftsartikel (refereegranskat)abstract
- We study the charge and spin dependent scattering in a set of CoFeB thin films whose crystalline order is systematically enhanced and controlled by annealing at increasingly higher temperatures. Terahertz conductivity measurements reveal that charge transport closely follows the development of the crystalline phase, with the increasing structural order leading to higher conductivity. The terahertz-induced ultrafast demagnetization, driven by spin-flip scattering mediated by the spin–orbit interaction, is measurable in the pristine amorphous sample and much reduced in the sample with the highest crystalline order. Surprisingly, the largest demagnetization is observed at intermediate annealing temperatures, where the enhancement in spin-flip probability is not associated with an increased charge scattering. We are able to correlate the demagnetization amplitude with the magnitude of the in-plane magnetic anisotropy, which we characterize independently, suggesting a magnetoresistance-like description of the phenomenon.
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