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Träfflista för sökning "WFRF:(Small N) srt2:(2005-2009)"

Sökning: WFRF:(Small N) > (2005-2009)

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1.
  • Brooks, P, et al. (författare)
  • A predictive framework for coupling Hydrology, Biogeochemistry, and Ecology
  • 2008
  • Ingår i: Vol. 10, EGU2008-A-09502, 2008.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • The coupling of hydrological, biogeochemical, and ecological processes at catchment to landscape scale results in observable patterns in ecosystem structure, the amount and chemistry of stream discharge, and landsurface-atmosphere exchanges of energy and biogeochemicals. All of these patterns result from the close coupling of water, energy, carbon, and nutrient cycling, yet rarely are both the vertical (landsurfaceatmosphere) and lateral (hydrological residence time and streamflow) exchanges associated with a particular ecosystem structure studied in concert. Our research attempts to bridge this gap by focusing on how ecosystem structure, specifically vegetation, mediates four-dimensional (X,Y,Z, and time) fluxes of water, carbon, and nutrients in semi-arid environments of the southwestern United States. Our generalized approach involves an iterative combination of measurement, modeling, and experimentation where process-level inferences drawn from one research activity are used to develop testable hypothesis for related efforts. Preliminary results have linked spatial variability in hydrologic residence time to seasonal variability in nutrient limitation; spatial and interannual variability in water source with carbon uptake and isotopic signature; vegetation controls on both snow water input and soil moisture; and the importance of alluvial aquifers in stream and river biogeochemistry.
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2.
  • Jallow, Muminatou, et al. (författare)
  • Genome-wide and fine-resolution association analysis of malaria in West Africa.
  • 2009
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; , s. 657-665
  • Tidskriftsartikel (refereegranskat)abstract
    • We report a genome-wide association (GWA) study of severe malaria in The Gambia. The initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a replication study included 3,400 children. We used this to examine the performance of GWA methods in Africa. We found considerable population stratification, and also that signals of association at known malaria resistance loci were greatly attenuated owing to weak linkage disequilibrium (LD). To investigate possible solutions to the problem of low LD, we focused on the HbS locus, sequencing this region of the genome in 62 Gambian individuals and then using these data to conduct multipoint imputation in the GWA samples. This increased the signal of association, from P = 4 x 10(-7) to P = 4 x 10(-14), with the peak of the signal located precisely at the HbS causal variant. Our findings provide proof of principle that fine-resolution multipoint imputation, based on population-specific sequencing data, can substantially boost authentic GWA signals and enable fine mapping of causal variants in African populations.
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