SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Smith AD) srt2:(2015-2019)"

Search: WFRF:(Smith AD) > (2015-2019)

  • Result 1-10 of 87
Sort/group result
   
EnumerationReferenceCoverFind
1.
  •  
2.
  •  
3.
  •  
4.
  • Clark, DW, et al. (author)
  • Associations of autozygosity with a broad range of human phenotypes
  • 2019
  • In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4957-
  • Journal article (peer-reviewed)abstract
    • In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-10 of 87
Type of publication
journal article (84)
conference paper (2)
Type of content
peer-reviewed (77)
other academic/artistic (9)
Author/Editor
Metspalu, A (31)
Gudnason, V (23)
Martin, NG (23)
Esko, T (23)
Uitterlinden, AG (22)
Hayward, C. (22)
show more...
Hottenga, JJ (21)
Montgomery, GW (20)
Psaty, BM (20)
Stefansson, K (20)
Teumer, A (19)
van Duijn, CM (18)
Jukema, JW (18)
Gordon, SD (18)
Milani, L (18)
Sullivan, PF (17)
Boomsma, DI (17)
Rotter, JI (17)
Deary, IJ (17)
Lewis, CM (17)
Borglum, AD (17)
Ripke, S (17)
Boerwinkle, E (17)
Kutalik, Z. (17)
Lehtimaki, T. (17)
O'Donovan, MC (17)
Gill, M. (17)
Baune, BT (16)
Werge, T (16)
Smith, AV (16)
Hofman, A (16)
Nothen, MM (16)
Medland, SE (16)
Mors, O (16)
Owen, MJ (16)
Willemsen, G (15)
Wang, YP (15)
Amin, N (15)
Penninx, BWJH (15)
Breen, G (15)
Mattheisen, M (15)
Milaneschi, Y (15)
Cichon, S (15)
McIntosh, AM (15)
Rietschel, M (15)
Ikram, MA (15)
Lucae, S (15)
Hougaard, DM (15)
Elliott, P (15)
Grove, J (15)
show less...
University
Karolinska Institutet (85)
Lund University (22)
Uppsala University (18)
University of Gothenburg (14)
Umeå University (11)
Högskolan Dalarna (7)
show more...
Chalmers University of Technology (3)
Stockholm University (2)
Linköping University (2)
Royal Institute of Technology (1)
Stockholm School of Economics (1)
University of Skövde (1)
show less...
Language
English (87)
Research subject (UKÄ/SCB)
Medical and Health Sciences (43)
Natural sciences (3)
Engineering and Technology (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view