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Träfflista för sökning "WFRF:(Smoller JW) srt2:(2011-2014)"

Sökning: WFRF:(Smoller JW) > (2011-2014)

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  • Kong, J, et al. (författare)
  • S1 is associated with chronic low back pain: a functional and structural MRI study
  • 2013
  • Ingår i: Molecular pain. - : SAGE Publications. - 1744-8069. ; 9, s. 43-
  • Tidskriftsartikel (refereegranskat)abstract
    • A fundamental characteristic of neural circuits is the capacity for plasticity in response to experience. Neural plasticity is associated with the development of chronic pain disorders. In this study, we investigated 1) brain resting state functional connectivity (FC) differences between patients with chronic low back pain (cLBP) and matched healthy controls (HC); 2) FC differences within the cLBP patients as they experienced different levels of endogenous low back pain evoked by exercise maneuvers, and 3) morphometric differences between cLBP patients and matched HC We found the dynamic character of FC in the primary somatosensory cortex (S1) in cLBP patients, i.e., S1 FC decreased when the patients experienced low intensity LBP as compared with matched healthy controls, and FC at S1 increased when cLBP patients experienced high intensity LBP as compared with the low intensity condition. In addition, we also found increased cortical thickness in the bilateral S1 somatotopically associated with the lower back in cLBP patients as compared to healthy controls. Our results provide evidence of structural plasticity co-localized with areas exhibiting FC changes in S1 in cLBP patients.
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  • Smoller, JW, et al. (författare)
  • Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
  • 2013
  • Ingår i: Lancet. - 1474-547X. ; 381:9875, s. 1371-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Findings from family and twin studies suggest that genetic contributions to psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to identify specific variants underlying genetic effects shared between the five disorders in the Psychiatric Genomics Consortium: autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia.
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