| 1. |
- Chen, Guanying, et al.
(författare)
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(alpha-NaYbF4:Tm3+)/CaF2 Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging
- 2012
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Ingår i: ACS Nano. - : American Chemical Society (ACS). - 1936-0851 .- 1936-086X. ; 6:9, s. 8280-8287
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Tidskriftsartikel (refereegranskat)abstract
- We describe the development of novel and biocompatible core/shell (alpha-NaYbF4:Tm3+)/CaF2 nanoparticles that exhibit highly efficient NIRin-NIROut upconversion (UC) for high contrast and deep bioimaging. When excited at similar to 980 nm, these nanoparticles emit photoluminescence (PL) peaked at similar to 800 nm. The quantum yield of this UC PL under low power density excitation (similar to 0.3 W/cm(2)) is 0.6 +/- 0.1%. This high UC PL efficiency is realized by suppressing surface quenching effects via heteroepitaxial growth of a biocompatible CaF2 shell, which results in a 35-fold increase in the intensity of UC PL from the core. Small-animal whole-body UC PL imaging with exceptional contrast (signal-to-background ratio of 310) is shown using BALB/c mice intravenously injected with aqueously dispersed nanoparticles (700 pmol/kg). High-contrast UC PL imaging of deep tissues is also demonstrated, using a nanoparticle-loaded synthetic fibrous mesh wrapped around rat femoral bone and a cuvette with nanoparticle aqueous dispersion covered with a 3.2 cm thick animal tissue (pork).
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| 2. |
- Chen, Lei, 1981-, et al.
(författare)
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Mathematical Modeling for Optimal Deployment of In-Building Distributed Antenna Systems
- 2012
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Ingår i: Communications in China (ICCC), 2012. - : IEEE. - 9781467328142 ; , s. 786-791
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Konferensbidrag (refereegranskat)abstract
- In-building Distributed Antenna System (IB-DAS) has been proved to be one of the most efficient methods to provide sufficient coverage and capacity for indoor users. The target of a successful IB-DAS deployment is to guarantee the coverage as well as the capacity of the in-building areas with minimum deployment cost. We consider the optimaldeployment of the IB-DAS based on passive DAS in this paper. Mixed Integer Programming model has been developed forthe topology design of IB-DAS through the optimal installation of power splitters in order to connect all the antennas with minimum cable cost, meanwhile, the transmit power at each antenna are kept within the satisfied level for the service guarantee. The model can deliver optimal solutions to systems with a practical size where passive DAS is commonly deployed. To improve the time efficiency, preprocessing has been done to integrate the building layout data into themodeling. Application of the model over realistic IB-DAS deployment has been conducted, which demonstrates the effectiveness of the model.
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| 3. |
- Cruz, Jose Almeida, et al.
(författare)
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RNA-Puzzles : A CASP-like evaluation of RNA three-dimensional structure prediction
- 2012
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Ingår i: RNA. - : Cold Spring Harbor Laboratory. - 1355-8382 .- 1469-9001. ; 18:4, s. 610-625
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Tidskriftsartikel (refereegranskat)abstract
- We report the results of a first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles. The goals are to assess the leading edge of RNA structure prediction techniques; compare existing methods and tools; and evaluate their relative strengths, weaknesses, and limitations in terms of sequence length and structural complexity. The results should give potential users insight into the suitability of available methods for different applications and facilitate efforts in the RNA structure prediction community in ongoing efforts to improve prediction tools. We also report the creation of an automated evaluation pipeline to facilitate the analysis of future RNA structure prediction exercises.
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| 4. |
- Fu, Yifeng, 1984, et al.
(författare)
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Templated Growth of Covalently Bonded Three-Dimensional Carbon Nanotube Networks Originated from Graphene
- 2012
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Ingår i: Advanced Materials. - : Wiley. - 0935-9648 .- 1521-4095. ; 24:12, s. 1576-1581
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Tidskriftsartikel (refereegranskat)abstract
- A template-assisted method that enables the growth of covalently bonded three-dimensional carbon nanotubes (CNTs) originating from graphene at a large scale is demonstrated. Atomic force microscopy-based mechanical tests show that the covalently bonded CNT structure can effectively distribute external loading throughout the network to improve the mechanical strength of the material.
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| 5. |
- Li, Qiang, et al.
(författare)
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Plasmonic devices for optical interconnect
- 2012
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Ingår i: Proc. - ICOCN: Int. Conf. Opt. Commun. Networks. - 9781467349574 ; , s. 72-74
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Konferensbidrag (refereegranskat)abstract
- Plasmonic nanowire waveguides, hybrid couplers and planar couplers are potential optical interconnect components, which feature small footprint, low loss, high coupling efficiency at optical communication wavelength, and could be integrated to photonic integrated circuits.
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| 6. |
- Rockey, William M., et al.
(författare)
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Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling
- 2011
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Ingår i: Nucleic Acid Therapeutics. - : Mary Ann Liebert. - 2159-3337 .- 2159-3345. ; 21:5, s. 299-314
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Tidskriftsartikel (refereegranskat)abstract
- RNA aptamers represent an emerging class of pharmaceuticals with great potential for targeted cancer diagnostics and therapy. Several RNA aptamers that bind cancer cell-surface antigens with high affinity and specificity have been described. However, their clinical potential has yet to be realized. A significant obstacle to the clinical adoption of RNA aptamers is the high cost of manufacturing long RNA sequences through chemical synthesis. Therapeutic aptamers are often truncated postselection by using a trial-and-error process, which is time consuming and inefficient. Here, we used a rational truncation approach guided by RNA structural prediction and protein/RNA docking algorithms that enabled us to substantially truncateA9, an RNA aptamer to prostate-specific membrane antigen (PSMA),with great potential for targeted therapeutics. This truncated PSMA aptamer (A9L; 41mer) retains binding activity, functionality, and is amenable to large-scale chemical synthesis for future clinical applications. In addition, the modeled RNA tertiary structure and protein/RNA docking predictions revealed key nucleotides within the aptamer critical for binding to PSMA and inhibiting its enzymatic activity. Finally, this work highlights the utility of existing RNA structural prediction and protein docking techniques that may be generally applicable to developing RNA aptamers optimized for therapeutic use. © 2011 Mary Ann Liebert, Inc.
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| 7. |
- Tian, Jie, et al.
(författare)
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Nanowaveguides and couplers based on hybrid plasmonic modes
- 2010
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Ingår i: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 97:23, s. 231121-
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Tidskriftsartikel (refereegranskat)abstract
- Experimental demonstration of silicon nanowires based hybrid plasmonic waveguides and couplers with subwavelength mode confinement at the near infrared wavelength lambda = 980 nm are presented. By measuring the radiating light from the discontinuities in a nanowire, the estimated propagation length of the hybrid plasmonic waveguide is about 30 mu m (corresponding to a propagation loss of similar to 0.14 dB/mu m). For the coupler, the experimental results show that the hybrid plasmonic modes can be efficiently coupled between two overlapping nanowires only with a 1.9 mu m long coupling length.
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| 8. |
- Zhao, Wang, et al.
(författare)
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Non-data-aided timing acquisition for asynchronous IDMA systems
- 2013
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Ingår i: Wireless personal communications. - : Springer Science+Business Media B.V.. - 0929-6212 .- 1572-834X. ; 69:2, s. 957-978
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Tidskriftsartikel (refereegranskat)abstract
- Sample-timing error can cause significant performance degradation for the interleave-division multiple-access systems (Wang et al.2009). In this paper, we propose a nondata-aided timing acquisition scheme tomitigate sample-timing error due to the asynchronoustransmission of random allocated user ends (UEs) on the uplink.Aclosed-loop timing control scheme is constructed for the asynchronous IDMA system in this paper.We use the extrinsic information generated during the iterative detection algorithm with signal noise ratio volution to estimate the timing offset for the asynchronous uplink in the base station (BS) receiver. The BS receiver returns the timing control bits, which is generated with estimated timing offsets, to the corresponding UE. And the UE uses the timing control bits to adjust local transmission time to guarantee the sampling performance at the BS receiver. The simulation results show that the proposed acquisition scheme based on feedback loop can provide high acquisition probability and low false alarm probability. The proposed scheme can overcome the bit-error-rate performance bottleneck, which is caused by the sample-timing error in BS receiver due to the asynchronous signals in the uplink.
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