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- Boremalm, Malin, et al.
(författare)
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Discontinuation and dose reduction of rituximab in relapsing-remitting multiple sclerosis
- 2021
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Ingår i: Journal of Neurology. - : Springer. - 0340-5354 .- 1432-1459. ; 268:6, s. 2161-2168
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Tidskriftsartikel (refereegranskat)abstract
- Background: Rituximab is safe and effective for treating relapsing–remitting multiple sclerosis (RRMS) according to phase II and observational studies. There are limited data on disease activity after discontinuation and dose reduction. The objective of this study was to evaluate the effects on inflammatory disease activity after discontinuation or dose reduction of rituximab in patients with RRMS or clinically isolated syndrome (CIS).Methods: In this retrospective observational study, we included all RRMS and CIS patients ever treated with rituximab at the University Hospital of Umeå who had either; (1) discontinued treatment at any time or (2) reduced the dose to a mean of < 1000 mg yearly. The patients served as their own controls by contributing patient years on full dose, reduced dose, and off treatment.Results: A total of 225 patients treated with mean (SD) 6256 (2456) mg rituximab during mean (SD) 6.5 (2.0) years were included. There were no differences regarding the annualized relapse rates during full dose versus reduced dose or off treatment (0.02 versus < 0.01 and 0.02, p = 0.09), neither regarding proportion MRI scans with new or enlarged T2 lesions (0.03 versus 0.01 and 0.03, p = 0.37) or contrast-enhancing lesions (< 0.01 versus 0 and 0.02, p = 0.22).Conclusions: This study indicates that rituximab has long-term effects on inflammatory disease activity and that disease reactivation is rare in MS patients who discontinued treatment for any reason. It also suggests that treatment with low-dose rituximab (< 1000 mg yearly) is sufficient to maintain suppression of inflammatory disease activity in patients with stable disease.
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| 2. |
- Borgström, Benedikte, et al.
(författare)
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Smart Consumer-Oriented Urban Logistics
- 2021
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Service innovation is the nexus between the growing e-commerce in urban areas and the ongoing Corona pandemic and seasonal peaks like Christmas. The growing market of urban e-commerce logistics needs solution-driven freight and urban logistics, which is an assumption of this study. Consumer-oriented urban logistics services enable consumers in their everyday and enable a well-functioning urban logistics market are a co-operation between consumers and urban service providers. A service-logic perspective may offer service innovation and value co-creation for the urban logistics challenge that includes last mile logistics.This conceptual paper aims to develop strategic logistics service provision literature and service innovation literature to facilitate collaborative development between consumers and service providers. Central aspects are consumer's everyday routines and available solutions in terms of urban deliveries and returns, available interaction points between consumers and service providers in daily practices, and knowledge and resources of urban service provider (related to e-commerce logistics) for innovative offerings. The everyday consumption practice and its logistics are key in co-created service innovations. In-depth understanding of consumption practices and production practices is the basis to align resources for a differentiated urban logistics solution. Such a process develops both urban service consumption practices and production practices. Urban service providers like logistics firms, commercial real estaters, and e-retailers have complementary types of competencies to facilitate urban service innovation. The study will generate implications to the urban e-commerce logistics research area and benefit both academia and business.
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| 3. |
- Boström, Margareta, et al.
(författare)
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Lojalitet på riktigt
- 2021. - 1
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- På olika plan i samhället diskuteras lojalitet och man är överens om att lojalitet är viktigt för människor och för olika typer av verksamheter. Men vad är lojalitet? Och hur uppstår lojalitet hos människan? Hur kan verksamheter främja lojalitet?Denna bok reder ut begreppet lojalitet och placerar in det i ett större sammanhang. Boken bidrar till en djupare insikt om vad lojalitet innebär och manar läsaren till att reflektera över begreppet och över vad som egentligen är lojalitetsfrämjande. Läsaren får också konkret hjälp att förstå hur lojalitet kan främjas, utvärderas och mätas i den egna verksamheten."Under tiden jag läste den här boken gick det fullständigt klart upp för mig vilken okunskap jag haft om lojalitetsbegreppet. Malin och Margareta ger mig alla nycklar till vad lojalitet betyder och hur det fungerar, kort sagt de reder ut begreppen och ger många och handfasta guider till hur verksamheter kan ge förutsättningar för lojalitet."Arne B. Andersson, e-handels- och logistikexpert, "Arnepåposten", tidigare Postnord AB"Med stort engagemang och en stark vilja att låta läsaren få en djupare förståelse för begreppet lojalitet, har Margareta och Malin skrivit en inspirerande och engagerande bok som alla borde ta sig tid att läsa. Boken låter dig fundera och ifrågasätta samtidigt som den ger dig verktyg för att kunna förstå begreppet lojalitet bättre."Joachim Frykberg, vd Jula Holding AB och Jula AB
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| 5. |
- Edvinsson, Åsa, 1982-, et al.
(författare)
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Placental glucocorticoid receptors are not affected by maternal depression or SSRI treatment.
- 2020
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Ingår i: Upsala Journal of Medical Sciences. - : Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 125:1, s. 30-36
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Tidskriftsartikel (refereegranskat)abstract
- Background: Prenatal depression is common, with an estimate that up to one in five pregnant women suffers from depressive symptoms. Maternal depression is associated with poor pregnancy outcomes such as preterm birth and low birth-weight. Such outcomes possibly affect offspring development. Previous studies suggest placental RNA levels of the glucocorticoid receptor are altered by maternal depression or anxiety; this stress may affect the placenta of male and female foetuses differently. However, it is unknown if the protein levels and activity of this receptor are additionally affected in women with depressive symptoms or being pharmacologically treated for depression.Methods: In this study, we investigated whether the glucocorticoid receptor (NR3C1) in the placenta is affected by maternal depression and/or selective serotonin reuptake inhibitor (SSRIs) treatment. Placentas from 45 women with singleton, term pregnancies were analysed by Western blot to determine glucocorticoid receptor levels, and by DNA-binding capacity to measure glucocorticoid receptor activation.Results: There were no differences in levels of the glucocorticoid receptor or activity between groups (control, depressive symptoms, and SSRI treatment; n = 45). Similarly, there was no difference in placental glucocorticoid receptor levels or activity dependent upon foetal sex.Conclusion: Maternal depression and SSRI treatment do not affect the glucocorticoid receptors in the placenta.
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| 6. |
- Hidalgo-Lopez, Esmeralda, et al.
(författare)
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Triple network model of brain connectivity changes related to adverse mood effects in an oral contraceptive placebo-controlled trial
- 2023
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Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Combined oral contraceptives (COC) are among the most commonly used contraceptive methods worldwide, and mood side effects are the major reason for discontinuation of treatment. We here investigate the directed connectivity patterns associated with the mood side effects of an androgenic COC in a double-blind randomized, placebo-controlled trial in women with a history of affective COC side effects (n = 34). We used spectral dynamic causal modeling on a triple network model consisting of the default mode network (DMN), salience network (SN) and executive control network (ECN). Within this framework, we assessed the treatment-related changes in directed connectivity associated with adverse mood side effects. Overall, during COC use, we found a pattern of enhanced connectivity within the DMN and decreased connectivity within the ECN. The dorsal anterior cingulate cortex (SN) mediates an increased recruitment of the DMN by the ECN during treatment. Mood lability was the most prominent COC-induced symptom and also arose as the side effect most consistently related to connectivity changes. Connections that were related to increased mood lability showed increased connectivity during COC treatment, while connections that were related to decreased mood lability showed decreased connectivity during COC treatment. Among these, the connections with the highest effect size could also predict the participants' treatment group above chance.
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| 7. |
- Jain, Sheenam, et al.
(författare)
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Toward a conceptualization of personalized services in apparel e-commerce fulfillment
- 2021
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Ingår i: Research Journal of Textile and Apparel. - : Emerald Group Publishing Limited. - 1560-6074. ; 25:4
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Tidskriftsartikel (refereegranskat)abstract
- Purpose – Today, customers’ perceived value does not only depend on the products, but also on the services provided by a firm. In e-commerce, it is important to shift the focus beyond the product and discuss the value of personalized services in the context of e-commerce fulfillment. Therefore, the purpose of this paper is twofold: to develop a conceptual framework proposing satisfaction through personalized services as a middle-range theory; and to suggest foundational premises supporting the theoretical framework, which in turn shape middle-range theory within the context of apparel e-commerce fulfillment.Design/methodology/approach – In this theory-driven paper, the authors apply the scientific circle of enquiry, as it demonstrates the role of theorizing with the help of middle-range theory and empirical evidence and as such provides a methodological scaffolding that connects theory formulation and verification. The authors synthesize literature related to customer perceived value (CPV) and satisfaction, followed by abduction focusing on understanding the empirical domain as it occurred in practice from company cases. The presented case studies are based on semi-structured interviews with three Swedish online retailers within the apparel industry. The theory-driven analysis results in suggestions of foundational premises.Findings – Based on the theoretical foundations and empirical generalizations, three propositions are suggested. The premises regarding satisfaction through personalized service applied in the domain of apparel e-commerce fulfillment are: to ensure customer satisfaction requires a value co-creation perspective using data during the pre-purchase phase; to ensure customer satisfaction and retention require added-value perspective during the post-purchase phase of the shopping journey, and to ensure satisfaction and convenience require an added-value perspective at the last mile.Practical implications – The apparel firms lose a substantial amount of revenue because of poor online customer satisfaction, leading to e-commerce not reaching its full potential. To enhance customer value, online retailers need to find a resort in advanced technologies and analytics to address customer satisfaction, and it is suggested that retailers shift their focus beyond the products and find ways to improve personalized service offerings to gain market advantage, improve fulfillment, drive sales and increase CPV.Originality/value – To consider personalized services as a source for improving e-commerce fulfillment and CPV, the main contribution of this study is conceptual as it presents a theoretical model developed from general theory, middle-range theory and verified with empirical claims.Keywords Customer satisfaction, Apparel industry, Customer perceived value, E-commerce fulfillment, Personalized services Paper type Research paper
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| 10. |
- Li, ShiNa, et al.
(författare)
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Two Tales of One City : Fantasy Proneness, Authenticity, and Loyalty of On-Screen Tourism Destinations
- 2021
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Ingår i: Journal of Travel Research. - : Sage Publications. - 0047-2875 .- 1552-6763. ; 60:8, s. 1802-1820
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Tidskriftsartikel (refereegranskat)abstract
- On-screen tourism destinations provide tourists with a mixture of reality and mass-media experience. This study builds a conceptual framework of authenticity evaluating the relationship between fantasy proneness, authenticity, and destination loyalty. It is among the first to compare perceived authenticity of dual images of a destination, both the film location and the story’s setting. Using Game of Thrones and the city of Dubrovnik as a case, it applies a mixed method of interviews followed by a main survey with both closed- and open-ended questions. The primary findings show that the relationship between authenticity of the film location (Dubrovnik) and loyalty is positive, but such relationship is insignificant for the authenticity of the story’s setting (King’s Landing). This investigation enriches our understanding of the complex assessments of authenticity and expands the theory of imagination by evaluating the effects of fantasy proneness on perceived authenticity in the context of on-screen tourism.
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