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- Tettey, Uniben Yao Ayikoe, et al.
(författare)
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Effects of different insulation materials on primary energy and CO2 emission of a multi-storey residential building
- 2014
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Ingår i: Energy and Buildings. - : Elsevier. - 0378-7788 .- 1872-6178. ; 82, s. 369-377
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we analyzed the implications of various insulation materials on the primary energy and CO2emission for material production of a residential building. We modeled changes to the original design ofthe building to achieve reference buildings to energy-efficiency levels of the Swedish building code of2012 or the Swedish Passivhus 2012 criteria. We varied the insulation materials in different parts of thereference buildings from mineral rock wool to glass wool, cellulose fiber, expanded polystyrene or foamglass. We compared the primary energy use and CO2emission from material production of functionallyequivalent reference and optimum versions of the building. The results showed a reduction of about 6–7%in primary energy use and 6–8% in CO2emission when the insulation material in the reference buildingsis changed from rock wool to cellulose fiber in the optimum versions. Also, the total fossil fuel use for onlyinsulation material production was reduced by about 39%. This study suggests that enhancing materialproduction technologies by reducing fossil fuel-use and increasing renewable energy sources, as wellas careful material choice with renewable-based raw materials can contribute significantly in reducingprimary energy use and GHG emission in the building sector.
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| 2. |
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| 3. |
- Tettey, Uniben Yao Ayikoe, et al.
(författare)
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Primary energy implications of different wall insulation materials for buildings in a cold climate
- 2014
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Ingår i: Energy Procedia: INTERNATIONAL CONFERENCE ON APPLIED ENERGY, ICAE2014. - : Elsevier. ; , s. 1204-1207
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Konferensbidrag (refereegranskat)abstract
- In this study, we investigate the influence of different external wall insulation systems on the primary energy use of a case study building in southern Sweden. We vary the insulation material of the external walls from rock wool to glass wool or expanded polystyrene (EPS) to achieve different energy-efficiency standards of the building. We apply appropriate thicknesses of the different insulation materials to achieve similar thermal transmittance (U-value) of the external walls under the different energy-efficiency standards. The different options are based on the same architectural design. We calculate and compare the primary energy for production of the insulation materials and for operation of the buildings. Rock wool gives the lowest primary energy for production, followed by glass wool and EPS for each energy efficiency standard, although the difference between rock wool and glass wool is small.
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| 4. |
- Wang, Zhaoming, et al.
(författare)
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Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
- 2014
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Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
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