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Träfflista för sökning "WFRF:(Ullah S) srt2:(2010-2014)"

Sökning: WFRF:(Ullah S) > (2010-2014)

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  • Ullah, S. M. Arman, et al. (författare)
  • Mobile robot navigation via olfaction
  • 2012
  • Ingår i: Adaptive Mobile Robotics. - 9789814415941 ; , s. 97-104
  • Konferensbidrag (refereegranskat)abstract
    • Mobile robot navigation via olfaction has been receiving considerable interest over recent years to assist in the development of advanced cognitive robots which are able to operate in natural environments. With the related advances in electronic noses, it is now possible to detect and recognize and locate a range of different odours for a variety of applications. This paper involves designing and building a chemical sensing mobile robot that is able to navigate using these latest olfactory sensors. A smart robot equipped with olfactory sensors is designed for performing various search tasks in chemical fields; these search tasks include locating point sources, following chemical trails and plume following and investigating how the search efficiencies can be enhanced.
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  • Arabi, A., et al. (författare)
  • Proteomic screen reveals Fbw7 as a modulator of the NF-kappa B pathway
  • 2012
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 3, s. 976-
  • Tidskriftsartikel (refereegranskat)abstract
    • Fbw7 is a ubiquitin-ligase that targets several oncoproteins for proteolysis, but the full range of Fbw7 substrates is not known. Here we show that by performing quantitative proteomics combined with degron motif searches, we effectively screened for a more complete set of Fbw7 targets. We identify 89 putative Fbw7 substrates, including several disease-associated proteins. The transcription factor NF-κB2 (p100/p52) is one of the candidate Fbw7 substrates. We show that Fbw7 interacts with p100 via a conserved degron and that it promotes degradation of p100 in a GSK3 2 phosphorylation-dependent manner. Fbw7 inactivation increases p100 levels, which in the presence of NF-κB pathway stimuli, leads to increased p52 levels and activity. Accordingly, the apoptotic threshold can be increased by loss of Fbw7 in a p100-dependent manner. In conclusion, Fbw7-mediated destruction of p100 is a regulatory component restricting the response to NF-κB2 pathway stimulation.
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