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1.	Jukema, JW, et al. (author) Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome: ODYSSEY OUTCOMES Trial 2019 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 74:9, s. 1167-1176 Journal article (peer-reviewed)
2.	Ray, KK, et al. (author) Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial 2019 In: The lancet. Diabetes & endocrinology. - 2213-8595 .- 2213-8587. ; 7:8, s. 618-628 Journal article (peer-reviewed)
3.	Roe, MT, et al. (author) Risk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromes 2019 In: Circulation. - : Ovid Technologies (Wolters Kluwer Health). - 1524-4539 .- 0009-7322. ; 140:19, s. 1578-1589 Journal article (peer-reviewed)
4.	Szarek, M, et al. (author) Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial 2019 In: Circulation. Cardiovascular quality and outcomes. - : Ovid Technologies (Wolters Kluwer Health). - 1941-7705 .- 1941-7713. ; 12:11, s. e005858- Journal article (peer-reviewed)
5.	Szarek, M, et al. (author) Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events: The ODYSSEY OUTCOMES Trial 2019 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 73:4, s. 387-396 Journal article (peer-reviewed)
6.	Bittner, VA, et al. (author) Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome 2020 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 75:2, s. 133-144 Journal article (peer-reviewed)
7.	Goodman, SG, et al. (author) Effects of Alirocumab on Cardiovascular Events After Coronary Bypass Surgery 2019 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 74:9, s. 1177-1186 Journal article (peer-reviewed)
8.	Schwartz, GG, et al. (author) Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome 2018 In: The New England journal of medicine. - : MASSACHUSETTS MEDICAL SOC. - 1533-4406 .- 0028-4793. ; 379:22, s. 2097-2107 Journal article (peer-reviewed)
9.	Locke, Adam E, et al. (author) Genetic studies of body mass index yield new insights for obesity biology. 2015 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401 Journal article (peer-reviewed)abstract Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
10.	Speliotes, Elizabeth K., et al. (author) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index 2010 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948 Journal article (peer-reviewed)abstract Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

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Type of publication: journal article (79)

Type of content: peer-reviewed (79)

Author/Editor: Campbell, Harry (55); Rudan, Igor (55); Wilson, James F. (55); Wright, Alan F. (51); Hayward, Caroline (50); Vitart, Veronique (44); show more...; Polasek, Ozren (44); Gyllensten, Ulf (39); van Duijn, Cornelia ... (38); Hofman, Albert (36); Wild, Sarah H (36); Johansson, Åsa (33); Uitterlinden, André ... (32); Pramstaller, Peter P ... (31); Kolcic, Ivana (29); Gudnason, Vilmundur (29); Oostra, Ben A. (28); Gieger, Christian (28); Hicks, Andrew A. (27); Mangino, Massimo (26); Harris, Tamara B (26); Rivadeneira, Fernand ... (25); Salomaa, Veikko (24); Wareham, Nicholas J. (24); Wichmann, H. Erich (23); Loos, Ruth J F (23); Perola, Markus (22); Metspalu, Andres (22); Launer, Lenore J (22); Esko, Tõnu (22); Zgaga, Lina (21); Boerwinkle, Eric (21); Ripatti, Samuli (20); Boomsma, Dorret I. (20); Meitinger, Thomas (20); Isaacs, Aaron (20); Prokopenko, Inga (20); Chasman, Daniel I. (19); Spector, Tim D. (19); Psaty, Bruce M (19); Hottenga, Jouke-Jan (19); McCarthy, Mark I (18); Ridker, Paul M. (18); Stefansson, Kari (18); Shuldiner, Alan R. (18); Willemsen, Gonneke (18); Martin, Nicholas G. (18); Zhao, Jing Hua (18); Homuth, Georg (18); Zemunik, Tatijana (18); show less...

University: Uppsala University (65); Karolinska Institutet (37); Lund University (23); University of Gothenburg (19); Umeå University (13); Stockholm University (4); show more...; Mid Sweden University (3); Chalmers University of Technology (3); Högskolan Dalarna (3); Stockholm School of Economics (2); Linköping University (1); Linnaeus University (1); Swedish University of Agricultural Sciences (1); show less...

Language: English (79)

Research subject (UKÄ/SCB): Medical and Health Sciences (46); Natural sciences (14); Engineering and Technology (1); Humanities (1)

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