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Träfflista för sökning "WFRF:(Zhang John) srt2:(2000-2004)"

Sökning: WFRF:(Zhang John) > (2000-2004)

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  • Emterling, Anna, et al. (författare)
  • Clinicopathological significance of Nup88 expression in patients with colorectal cancer
  • 2003
  • Ingår i: Oncology. - : S. Karger AG. - 0890-9091 .- 0030-2414 .- 1423-0232. ; 64:4, s. 361-369
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: The nucleoporin Nup88 is overexpressed in a series of human malignancies, however, its clinicopathological significance has not been studied. Our aims were to analyze Nup88 expression in normal mucosa, primary tumors and metastases from colorectal cancer patients and further to identify relationships of Nup88 expression with clinicopathological and other factors.Materials and Methods: Using immunohistochemistry, we investigated Nup88 expression in 198 primary colorectal tumors, 96 normal mucosa samples and 35 lymph node metastases.Results: The results showed that the intensity of Nup88 expression increased from the normal mucosa to the primary tumors (p < 0.0001) and tended to increase from the primary tumors to the metastases (p = 0.15). Both primary tumors and metastases presented stronger expression in the invasive margin and vascular-invaded areas. Nup88 expression was positively related to distal tumor location (p = 0.01), infiltrative growth pattern (p = 0.04) and higher proliferative activity (p = 0.04) and reversely to the grade of differentiation (p = 0.02) and apoptosis (p = 0.049). Strong expression of Nup88 predicted a worse outcome in the patients with distal tumors during the follow-up period of up to 3 years (p = 0.02).Conclusions: It seems that overexpression of Nup88 was involved in the tumorigenesis and aggressiveness of colorectal cancers, and Nup88 may be used as a prognostic factor in patients with distal tumors.
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  • Lygeros, John, et al. (författare)
  • Continuity and invariance in hybrid automata
  • 2001
  • Ingår i: Proceedings of the 40th IEEE Conference on Decision and Control, 2001. - : IEEE. - 0780370619 ; , s. 340-345
  • Konferensbidrag (refereegranskat)abstract
    • Hybrid automata have been proposed as a language for modelling and analysing the interaction of digital and analogue dynamics in embedded computer systems. In the paper, hybrid automata are studied from a dynamical systems perspective. Extending earlier work on conditions for existence and uniqueness of executions of hybrid automata, we characterise a class of hybrid automata whose executions depend continuously on the initial state. The continuity conditions are subsequently used to derive an extension of LaSalle's principle for studying the stability of invariant sets of states of hybrid automata
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  • Zhang, Jun, et al. (författare)
  • Dynamical systems revisited : Hybrid systems with Zeno executions
  • 2000
  • Ingår i: Lecture Notes in Computer Science. - : Springer Berlin/Heidelberg. - 0302-9743 .- 1611-3349. ; 1790, s. 451-464
  • Tidskriftsartikel (refereegranskat)abstract
    • Results from classical dynamical systems are generalized to hybrid dynamical systems. The concept of omega limit set is introduced for hybrid systems and is used to prove new results on invariant sets and stability, where Zeno and non-Zeno hybrid systems can be treated within the same framework. As an example, LaSalle's Invariance Principle is extended to hybrid systems. Zeno hybrid systems are discussed in detail. The omega limit set of a Zeno execution is characterized for classes of hybrid systems.
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  • Resultat 1-6 av 6

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