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The crystal structu...
The crystal structure of human adenylate kinase 6 : An adenylate kinase localized to the cell nucleus
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Ren, Hui (author)
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Wang, Liya (author)
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- Bennett, Matthew (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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Liang, Yuhe (author)
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Zheng, Xiaofeng (author)
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Lu, Fei (author)
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Li, Lanfen (author)
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- Nan, Jie (author)
- Lund University,Lunds universitet,MAX IV-laboratoriet,MAX IV Laboratory
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Luo, Ming (author)
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- Eriksson, Staffan (author)
- Lund University,Lunds universitet,Hållbar vardag och hälsa i ett livsperspektiv,Forskargrupper vid Lunds universitet,Sustainable occupations and health in a life course perspective,Lund University Research Groups
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Zhang, Chuanmao (author)
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- Su, Xiao-Dong (author)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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(creator_code:org_t)
- 2005-01-03
- 2005
- English 6 s.
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In: Proceedings of the National Academy of Sciences. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 102:2, s. 8-303
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Abstract
Subject headings
Close
- Adenylate kinases (AKs) play important roles in nucleotide metabolism in all organisms and in cellular energetics by means of phosphotransfer networks in eukaryotes. The crystal structure of a human AK named AK6 was determined by in-house sulfur single-wavelength anomalous dispersion phasing methods and refined to 2.0-A resolution with a free R factor of 21.8%. Sequence analyses revealed that human AK6 belongs to a distinct subfamily of AKs present in all eukaryotic organisms sequenced so far. Enzymatic assays show that human AK6 has properties similar with other AKs, particularly with AK5. Fluorescence microscopy showed that human AK6 is localized predominantly to the nucleus of HeLa cells. The identification of a nuclear-localized AK sheds light on nucleotide metabolism in the nucleus and the energetic communication between mitochondria and nucleus by means of phosphotransfer networks.
Keyword
- Active Transport, Cell Nucleus
- Adenylate Kinase
- Amino Acid Sequence
- Crystallography, X-Ray
- HeLa Cells
- Humans
- Isoenzymes
- Molecular Sequence Data
- Nucleotides
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Ren, Hui
-
Wang, Liya
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Bennett, Matthew
-
Liang, Yuhe
-
Zheng, Xiaofeng
-
Lu, Fei
-
show more...
-
Li, Lanfen
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Nan, Jie
-
Luo, Ming
-
Eriksson, Staffa ...
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Zhang, Chuanmao
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Su, Xiao-Dong
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show less...
- Articles in the publication
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Proceedings of t ...
- By the university
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Lund University