| 1. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Li, Xuping, et al.
(författare)
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A three-dimensional ratiometric sensing strategy on unimolecular fluorescence-thermally activated delayed fluorescence dual emission
- 2019
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Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Visualized sensing through fluorescence signals is a powerful method for chemical and physical detection. However, the utilization of fluorescent molecular probes still suffers from lack of precise signal self-calibration in practical use. Here we show that fluorescence and thermally activated delayed fluorescence can be simultaneously produced at the single-molecular level. The thermally activated delayed fluorescence serves as a sensing signal with its wavelength and lifetime both altered correlating to polarity, whereas the fluorescence always remains unchanged as an internal reference. Upon the establishment of a three-dimensional working curve upon the ratiometric wavelength and photoluminescence lifetime vs. polarity, disturbance factors during a relevant sensing process can be largely minimized by such a multiple self-calibration. This strategy was further applied into a precise detection of the microenvironmental polarity variation in complex phospholipid systems, towards providing new insights for convenient and accurate diagnosis of membrane lesions.
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| 3. |
- Liu, Kaifei, et al.
(författare)
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Regulatory role of Golgi brefeldin A resistance factor-1 in amyloid precursor protein trafficking, cleavage and Aβ formation
- 2019
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Ingår i: Journal of Cellular Biochemistry. - Hoboken : John Wiley & Sons. - 0730-2312 .- 1097-4644. ; 120:9, s. 15604-15615
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Tidskriftsartikel (refereegranskat)abstract
- β-amyloid peptide (Aβ) deposition derived from sequential cleavage of the amyloid precursor protein (APP) through the amyloidogenic pathway is an important characteristic feature of Alzheimer's disease (AD). During this process, cellular trafficking plays a crucial role. A large Sec7-domain containing ADP-ribosylation factor guanine nucleotide exchange factor (ARF-GEF), Golgi brefeldin A resistance factor 1 (GBF1) has been reported to initiate the ADP-ribosylation factor (Arf) activation cascade at trans-Golgi network, which plays a crucial function at the endoplasmic reticulum-Golgi interface. In this study, we investigated the role of GBF1 in APP transmembrane transport and Aβ formation. Using APP/PS1 (presenilin 1) overexpressing transgenic mice, we demonstrate that GBF1 has upregulated the expression of APP, indicating a role for GBF1 in APP physiological process. Knocking down of GBF1 using small interfering has significantly increased the intracellular but not the surface expression of APP. In contrast, overexpression of wild-type (WT) and guanine nucleotide exchange factor (GEF) in the activated form but not the GEF deficient mutation induced continuous activation of GBF1, which subsequently increased the surface level of APP. Interestingly, inhibition of GBF1 by c(BFA) also impaired APP trafficking and induced endoplasmic reticulum (ER) stress in SH-SY5Y cells. Our results thus for identified the role of GBF1 in APP trafficking and cleavage, and provide evidence for GBF1 as a possible therapeutic target in AD. © 2019 Wiley Periodicals, Inc.
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| 4. |
- Liu, Yanrong, et al.
(författare)
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Cascade utilization of lignocellulosic biomass to high-value products
- 2019
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Ingår i: Green Chemistry. - : Royal Society of Chemistry. - 1463-9262 .- 1463-9270. ; 21:13, s. 3499-3535
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Tidskriftsartikel (refereegranskat)abstract
- Lignocellulosic biomass is a potential sustainable feedstock to replace fossil fuels. However, the complex structure of biomass makes it difficult to convert into high-value products. Utilization of lignocellulosic biomass in a green and effective way is of great significance for sustainable development. Based on the analysis of different options, we proposed that cascade utilization according to its composition, characteristics, and nature is the best way to utilize the lignocellulosic biomass. To promote the cascade utilization of lignocellulosic biomass, this article provides a review of the latest research results from the aspect of cascade utilization of lignocellulosic biomass covering the whole chain from pretreatment to high-value products, and the research on the non-conventional pretreatments including microwave irradiation, supercritical fluids, ultrasonic irradiation, electric field, hydrodynamic cavitation, and ionic liquids are presented in detail and evaluated by 4 proposed levels, and the newly developed high-value applications were further overviewed for lignin (carbon/graphene/carbon nano-tubes, dye dispersants, bioplastics, and aerogels), cellulose (cellulose-based ionic liquids, functional composites, adsorbent materials, carbon, and aerogels), and hemicellulose (films and pharmaceutical carriers), respectively. Finally, perspectives on the future research on the cascade utilization of lignocellulosic biomass are highlighted.
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| 5. |
- Liu, Yanrong, et al.
(författare)
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Preparation of MWCNTs-Graphene-Cellulose Fiber with Ionic Liquids
- 2019
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Ingår i: ACS Sustainable Chemistry and Engineering. - : American Chemical Society (ACS). - 2168-0485. ; 7:24, s. 20013-20021
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Tidskriftsartikel (refereegranskat)abstract
- The conductive multiwalled carbon nanotubes (MWCNTs)-graphene sheets (rGOs)-cellulose fiber was prepared with an eco-friendly wet-spinning method in which ionic liquid (IL) was used as both green solvent and dispersant. It was found that the selected IL 1-ethyl-3-methylimidazolium diethyl phosphate (EmimDep) shows remarkable capacities for dissolving cellulose and dispersing MWCNTs, and the synergistic effect of MWCNTs, rGOs, and cellulose results in a high electrical conductivity of 1195 S/m of MWCNTs-rGOs-cellulose fibers. Macropores and the double-layer structure of MWCNTs and rGOs can be observed by SEM in the studied fibers, and the number of macropores decreased with increasing rGOs amount, which is consistent with the result of the specific surface area. In addition, the prepared MWCNTs-rGOs-cellulose fibers present a nearly perfect electrical double-layer structure. The MWCNTs-rGOs-cellulose fiber with a mass ratio of 2:3:1 shows the best performance as the electrode candidate, with an electrical conductivity of 1195 S/m, specific capacitance of 597 mF/cm2, and specific surface area of 91 m2/g. Furthermore, the results from the molecular dynamics (MD) simulation evidenced that EmimDep can disperse CNTs effectively at 363.15 K, 1 atm compared to rGOs; the synergy effect of CNT and rGO exhibit great potential to enhance the dispersion than each individual component.
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| 6. |
- Liu, Yanrong, et al.
(författare)
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Study on ionic liquid/cellulose/coagulator phase diagram and its application in green spinning process
- 2019
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Ingår i: Journal of Molecular Liquids. - : Elsevier. - 0167-7322 .- 1873-3166. ; 289
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Tidskriftsartikel (refereegranskat)abstract
- In this work, the cellulose phase separation behavior was investigated by using ionic liquids (ILs) as novel solvents to acquire a green process for cellulose fiber spinning. The cloud point titration method combined with the turbidity correlation equation was used to obtain the ternary diagram of IL/cellulose/coagulator throughout the whole compositional range. The effects of the type of ILs, the cellulose materials, the kind of coagulators and the regeneration temperatures for cellulose fiber manufacturing process on the phase separation behavior were studied systematically. It was found that the linearized cloud point (LCP) curve correlation fits to experimental data well and can be used to quantify the optimized coagulator, and among the studied cases, the system of [EMIM]DEP, cotton pulp and water with the regeneration temperature at 298.15 K is the best. Meanwhile, COSMO-RS was used to predict the interaction between solvent, cellulose and coagulator, and the comparison with the LCP correlation shows good agreement. The crystal structure of the regenerated cotton pulp was determined with XRD, and the result evidences that the crystal structure of the regenerated cellulose transforms from cellulose I to cellulose II. The crystallinity decreases from 96.0% (raw cotton pulp) to 85.6% after 24 h dissolution in [EMIM]DEP at 363.15 K, and it has a slight deviation from 24 h to 72 h, which illustrates that the spinning process can run continuously at 363.15 K when using [EMIM]DEP as the solvent.
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| 7. |
- Xia, Xiaoyan, et al.
(författare)
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Effect of a two-stage intervention package on the cesarean section rate in Guangzhou, China: A before-and-after study.
- 2019
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Ingår i: PLoS medicine. - : Public Library of Science (PLoS). - 1549-1676. ; 16:7
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Tidskriftsartikel (refereegranskat)abstract
- The cesarean section (CS) rate has risen globally during the last two decades. Effective and feasible strategies are needed to reduce it. The aim of this study was to assess the CS rate change after a two-stage intervention package that was designed to reduce the overall CS rate in Guangzhou, China.This intervention package was implemented by the Health Commission of Guangzhou Municipality in 2 stages (October 2010-September 2014 and October 2014-December 2016) and included programs for population health education, skills training for healthcare professionals, equipment and technical support for local healthcare facilities, and capacity building for the maternal near-miss care system. A retrospective repeated cross-sectional study was conducted to evaluate influences of the intervention on CS rates. A pre-intervention period from January 2008 to September 2010 served as the baseline. The primary outcome was the CS rate, and the secondary outcomes included maternal mortality ratio (MMR) and perinatal mortality rate (PMR), all obtained from the Guangzhou Perinatal Health Care and Delivery Surveillance System (GPHCDSS). The Cochran-Armitage test was used to examine the trends of the overall CS rate, MMR, and PMR across different stages. Segmented linear regression analysis was used to assess the change of the CS rate over the intervention period. A total of 1,921,932 records of births and 108 monthly CS rates from 2008 to 2016 were analyzed. The monthly CS rate declined across the intervention stages (Z = 75.067, p < 0.001), with an average rate of 42.4% at baseline, 39.8% at Stage 1, and 35.0% at Stage 2. The CS rate declined substantially among nulliparous women who delivered term singletons, with an accelerating decreasing trend observed across Stage 1 and Stage 2 (the difference in slopes: -0.09 [95% CI -0.16 to -0.02] between Stage 1 and baseline, p = 0.014; -0.11 [95% CI -0.20 to -0.02] between Stage 1 and Stage 2, p = 0.017). The CS rate in the remaining population increased during baseline and Stage 1 and subsequently decreased during Stage 2. The sensitivity analysis suggested no immediate impact of the universal two-child policy on the trend of the CS rate. The MMR (Z = -4.368, p < 0.001) and PMR (Z = -13.142, p < 0.001) declined by stage over the intervention period. One of the main limitations of the study is the lack of a parallel control group. Moreover, the influence of temporal changes in the study population on the CS rate was unknown. Given the observational nature of the present study, causality cannot be confirmed.Apparent decline in the overall CS rate was observed in Guangzhou, China, after the implementation of a two-stage intervention package. The decline was most evident among nulliparous women who delivered term singletons. Despite some limitations for causal inference, Guangzhou's experience in controlling the CS rate by implementing composite interventions with public health education and perinatal healthcare service improvement could have implications for other similar areas with high rates of CS.
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| 8. |
- Zhang, Yue, et al.
(författare)
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Association between anthropometric indicators of obesity and cardiovascular risk factors among adults in Shanghai, China
- 2019
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Ingår i: BMC Public Health. - : BMC. - 1471-2458. ; 19:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: To determine the optimal cut-off values and evaluate the associations of body mass index (BMI), waist circumference (WC) and waist-height ratio (WHtR) with cardiovascular disease (CVD) risk factors. Methods: A large-scale cross-sectional survey was conducted among 35,256 adults aged 20-74 years in Shanghai between June 2016 and December 2017. Receiver operating characteristic (ROC) analyses were conducted to assess the optimal cut-off anthropometric indices of CVD risk factors including hypertension, diabetes, dyslipidemia and hyperuricemia. Multivariate Logistic regression models were preformed to evaluate the odds ratio of CVD risk factors. Results: The area under the curve (AUC) of WHtR was significantly greater than that of BMI or WC in the prediction of hypertension and diabetes, and AUCs were higher in women than men. The optimal cut-off values of WHtR were approximately 0.51 in both sexes, while the cut-off values of BMI and WC were higher for men compared with women. The optimal cutoff values of BMI and WC varied greatly across different age groups, but the difference in WHtR was relatively slight. Among women, the optimal threshold of anthropometric indices appeared to increase with age for hypertension and diabetes. The odds ratio between anthropometric indices and CVD risk factors were attenuated with age. WHtR had the greatest odds ratio for CVD risk factors among adults under 60 years old except for women with hypertension, while among 60-74 years, BMI yielded the greatest odds ratio in terms of all CVD outcomes except for women with diabetes. Conclusions: WHtR had the best performance for discriminating hypertension and diabetes and potentially be served as a standard screening tool in public health. The associations between three anthropometric indices and CVD risk factors differed by sex and decreased with age. These findings indicated a need to develop age- and gender-specific difference and make effective strategies for primary prevention of CVDs.
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