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Sökning: WFRF:(d'Amore Francesco) > (2005) > Medication use and ...

Medication use and risk of non-Hodgkin's lymphoma

Chang, Ellen T. (författare)
Karolinska Institutet
Smedby, Karin Ekström (författare)
Karolinska Institutet
Hjalgrim, Henrik (författare)
Karolinska Institutet
visa fler...
Schöllkopf, Claudia (författare)
Porwit-MacDonald, Anna (författare)
Karolinska Institutet
Sundström, Christer (författare)
Uppsala universitet,Institutionen för genetik och patologi
Tani, Edneia (författare)
d'Amore, Francesco (författare)
Melbye, Mads (författare)
Adami, Hans-Olov (författare)
Glimelius, Bengt (författare)
Karolinska Institutet
visa färre...
 (creator_code:org_t)
2005-09-28
2005
Engelska.
Ingår i: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 162:10, s. 965-974
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Conflicting results from previous epidemiologic studies shed little light on whether medication use is associated with risk of non-Hodgkin's lymphoma (NHL). To investigate this question, the authors conducted a population-based case-control study in Denmark and Sweden from 1999 to 2002, including 3,055 incident NHL cases and 3,187 controls. Participants reported their past use of medications and history of particular medical conditions. Unconditional logistic regression was used to estimate multivariate odds ratios and 95% confidence intervals for the associations between medication use and risk of NHL; all statistical tests were two sided. Use of antibiotics more than 10 times during adulthood was positively associated with risk of NHL and most major NHL subtypes; when users were compared with nonusers, the odds ratio for NHL was 1.8 (95% confidence interval: 1.4, 2.3); p(trend) for total antibiotic use <0.001. In addition, high cumulative use of nonsteroidal anti-inflammatory drugs was marginally associated with elevated NHL risk. Other medications evaluated were not associated with risk of NHL or its most common subtypes. Findings suggest that inflammation, infections, susceptibility to infections, and/or use of antibiotics or nonsteroidal anti-inflammatory drugs to treat these conditions may increase the risk of NHL. However, most of the medications examined were not associated with NHL risk.

Nyckelord

Adolescent
Adrenal Cortex Hormones/therapeutic use
Adult
Aged
Anti-Bacterial Agents/therapeutic use
Anti-Inflammatory Agents; Non-Steroidal/therapeutic use
Anticonvulsants/therapeutic use
Case-Control Studies
Denmark/epidemiology
Dose-Response Relationship; Drug
Drug Utilization
Female
Histamine Antagonists/therapeutic use
Humans
Lymphoma; Non-Hodgkin/*drug therapy/*epidemiology
Male
Middle Aged
Odds Ratio
Research Support; N.I.H.; Extramural
Research Support; Non-U.S. Gov't
Risk Factors
Sex Distribution
Sweden/epidemiology
MEDICINE
MEDICIN

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