| 1. |
- Martin-Boglind, Lene, et al.
(författare)
-
The effect of topical antiglaucoma drugs on the results of high-pass resolution perimetry
- 1991
-
Ingår i: American Journal of Ophthalmology. - 0002-9394 .- 1879-1891. ; 11:6, s. 711-714
-
Tidskriftsartikel (refereegranskat)abstract
- We conducted a randomly assigned, double-masked, crossover study of the effects of betaxolol, epinephrine, pilocarpine, and timolol on the high-passresolution perimetry results in normal subjects. The influence of topical administration of these intraocular pressure reducing drugs was negligible, which confirmed the reliability of high-pass resolution perimetry results. The method seems appropriate for the diagnosis of glaucoma and the follow-up ofpatients with glaucoma.
|
|
| 2. |
- Oohashi, T, et al.
(författare)
-
Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues
- 1999
-
Ingår i: Journal of Cell Biology. - 0021-9525. ; 145:3, s. 563-577
-
Tidskriftsartikel (refereegranskat)abstract
- The Drosophila gene ten-m/odz is the only pair rule gene identified to date which is not a transcription factor. In an attempt to analyze the structure and the function of ten-m/odz in mouse, we isolated four murine ten-m cDNAs which code for proteins of 2,700-2, 800 amino acids. All four proteins (Ten-m1-4) lack signal peptides at the NH2 terminus, but contain a short hydrophobic domain characteristic of transmembrane proteins, 300-400 amino acids after the NH2 terminus. About 200 amino acids COOH-terminal to this hydrophobic region are eight consecutive EGF-like domains. Cell transfection, biochemical, and electronmicroscopic studies suggest that Ten-m1 is a dimeric type II transmembrane protein. Expression of fusion proteins composed of the NH2-terminal and hydrophobic domain of ten-m1 attached to the alkaline phosphatase reporter gene resulted in membrane-associated staining of the alkaline phosphatase. Electronmicroscopic and electrophoretic analysis of a secreted form of the extracellular domain of Ten-m1 showed that Ten-m1 is a disulfide-linked dimer and that the dimerization is mediated by EGF-like modules 2 and 5 which contain an odd number of cysteines. Northern blot and immunohistochemical analyses revealed widespread expression of mouse ten-m genes, with most prominent expression in brain. All four ten-m genes can be expressed in variously spliced mRNA isoforms. The extracellular domain of Ten-m1 fused to an alkaline phosphatase reporter bound to specific regions in many tissues which were partially overlapping with the Ten-m1 immunostaining. Far Western assays and electronmicroscopy demonstrated that Ten-m1 can bind to itself.
|
|
| 3. |
- Sandberg Wollheim, Magnhild, et al.
(författare)
-
A long-term prospective study of optic neuritis: evaluation of risk factors
- 1990
-
Ingår i: Annals of Neurology. - : Wiley. - 1531-8249 .- 0364-5134. ; 27:4, s. 386-393
-
Tidskriftsartikel (refereegranskat)abstract
- Eighty-six patients with monosymptomatic optic neuritis of unknown cause were followed prospectively for a median period of 12.9 years. At onset, cerebrospinal fluid (CSF) pleocytosis was present in 46 patients (53%) but oligoclonal immunoglobulin in only 40 (47%) of the patients. The human leukocyte antigen (HLA)-DR2 was present in 45 (52%). Clinically definite multiple sclerosis (MS) was established in 33 patients. Actuarial analysis showed that the cumulative probability of developing MS within 15 years was 45%. Three risk factors were identified: low age and abnormal CSF at onset, and early recurrence of optic neuritis. Female gender, onset in the winter season, and the presence of HLA-DR2 antigen increased the risk for MS, but not significantly. Magnetic resonance imaging detected bilateral discrete white matter lesions, similar to those in MS, in 11 of 25 patients, 7 to 18 years after the isolated attack of optic neuritis. Nine were among the 13 with abnormal CSF and only 2 belonged to the group of 12 with normal CSF (p = 0.01). Normal CSF at the onset of optic neuritis conferred better prognosis but did not preclude the development of MS.
|
|
| 4. |
- Frisén, Lars, 1939, et al.
(författare)
-
A primer of ophthalmic computer graphics.
- 1990
-
Ingår i: Documenta ophthalmologica. Advances in ophthalmology. - 0012-4486. ; 74:4, s. 337-50
-
Tidskriftsartikel (refereegranskat)abstract
- Computer graphics offers an unprecedented opportunity to probe new and old ideas in vision testing, without going to the expense of building dedicated equipment. However, the large variety of computer hardware is bewildering and only occasionally can commercial software tools be used. This mini review of the basic principles of computer graphics on personal computers is intended to help the newcomer to the field.
|
|
| 5. |
- Frisén, Lars, 1939
(författare)
-
High-pass resolution perimetry. A clinical review.
- 1993
-
Ingår i: Documenta ophthalmologica. Advances in ophthalmology. - 0012-4486. ; 83:1, s. 1-25
-
Forskningsöversikt (refereegranskat)abstract
- Review of all available reports comparing high-pass resolution perimetry (HRP) and conventional perimetry in normals and in subjects with different visual disorders reveals closely comparable aspects of sensitivity, specificity, and reliability. HRP shows important advantages concerning variability, test duration, and subject preferences. Drawbacks seem largely limited to somewhat loose renditions of visual field defects of small area and large depth. Otherwise HRP's novel format of graphic result presentation may be better suited to visual evaluation than conventional gray-scale maps with their lumping of thresholds and extensive interpolations. Several examples are provided of visual field defects due to various lesions throughout the visual system.
|
|
| 6. |
- Frisén, Lars, 1939
(författare)
-
High-pass resolution perimetry and age-related loss of visual pathway neurons.
- 1991
-
Ingår i: Acta ophthalmologica. - 0001-639X. ; 69:4, s. 511-5
-
Tidskriftsartikel (refereegranskat)abstract
- The normal, age-related decline of results of high-pass resolution perimetry (HRP) predicts a loss of approximately 9,000 retino-cortical neural channels per year of age, or about 1 channel each hour. Previously published counts of numbers of neurons in the optic nerve indicate a loss of approximately 5,000 neurons per year. The HRP results can be accounted for by postulating that neurons are lost at the same rate also in the geniculo-striate visual pathway.
|
|
| 7. |
- Frisén, Lars, 1939
(författare)
-
High-pass resolution perimetry: central-field neuroretinal correlates.
- 1995
-
Ingår i: Vision research. - 0042-6989. ; 35:2, s. 293-301
-
Tidskriftsartikel (refereegranskat)abstract
- Minimum angles of resolution (MAR) were measured at 0-10 deg horizontal eccentricity in three normal subjects, using high-pass spatial frequency filtered targets, at four different contrast levels. Results were correlated with recent data on human cone and ganglion cell separations in corresponding retinal locations. MARs and cone separations showed a close proportionality through the origin for all contrast levels. Ganglion cell correlates were more difficult to elucidate as the cell bodies are displaced from their input cones. Taking a functional estimate of the displacement into account, the number of ganglion cells appeared to be large enough to uphold an "effective" distribution that obeys the same proportional relationship to MAR that previously has been demonstrated outside 10 deg. Analysis of the nature of age effects provided support for this model.
|
|
| 8. |
- Frisén, Lars, 1939, et al.
(författare)
-
Relative dispersion analysis enhances perimetric sensitivity.
- 1996
-
Ingår i: Vision research. - 0042-6989. ; 36:3, s. 491-7
-
Tidskriftsartikel (refereegranskat)abstract
- Objective identification of minor visual field defects is problematic. A possible solution is to examine spatial correlations by means of relative dispersion analysis, a tool of fractal analysis. We studied patients with glaucoma, previous optic neuritis, chiasmal compression and lesions of the brain hemispheres, using high-pass resolution perimetry. One-hundred visual field records were drawn consecutively for each category and ranked according to severity of defects. Records with scores ranking below the 35th percentile, i.e. those with the smallest field defects, were analysed. Relative dispersion analysis recognized 1.3-2.4 times more abnormal subjects than did pattern standard deviation. A previously described form index was intermediate in sensitivity. Specificity was 96%. Relative dispersion analysis appears to capture a novel aspect of visual field abnormality, with good sensitivity and specificity. The analysis is easily performed.
|
|
| 9. |
- Frisén, Lars, 1939, et al.
(författare)
-
Surgically created fourth-third cranial nerve communication: temporary success in a child with bilateral third nerve hamartomas. Case report.
- 1999
-
Ingår i: Journal of neurosurgery. - : Journal of Neurosurgery Publishing Group (JNSPG). - 0022-3085. ; 90:3, s. 542-5
-
Tidskriftsartikel (refereegranskat)abstract
- Shortly after birth, an otherwise healthy infant developed eye deviation and ptosis due to a hamartomatous lesion of the interpeduncular segment of the right oculomotor nerve. The left nerve became similarly involved when the child was 1.5 years of age. Direct nerve repair was not possible. Instead, the trochlear nerve was divided and its proximal end was attached to the distal end of the third nerve. Elevation of the upper eyelid and partial adduction of the eye developed gradually over the ensuing 3 to 5 months. Both functions were lost after an additional 2 months, presumably as a result of tumor recurrence or neuroma formation. This case report shows that surgically created fourth-third cranial nerve communication is feasible and may merit consideration under similar circumstances.
|
|
| 10. |
|
|
