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  • Appleyard, Bob, et al. (författare)
  • Best Practice Guideline: Transportation of People Seated in Wheelchairs, Version 2.21.
  • 2010
  • Ingår i: [Host publication title missing]. - PMG Posture and Mobility Group.
  • Konferensbidrag (refereegranskat)abstract
    • Summary, key points: Transport considerations ought to be factored into the initial phase of the wheelchair & seating assessment process. Manufacturers of wheelchairs and seating systems should make information relating to the safe transportation of their products readily available - and easy to understand. With the desire to provide the safest possible transport environment for wheelchair-seated passengers, and other vehicle occupants, all stakeholders must engage in a multi-disciplinary approach to ensuring transport safety; involving the wheelchair user with their families, carers, equipment prescribers, and transport providers*. A proven crashworthy wheelchair, used in conjunction with a proven wheelchair tie-down and occupant restraint system (WTORS), is fundamental to the provision of safe transport for both people who remain seated in their wheelchairs in a motor vehicle and other vehicle occupants. Exceptions exist on certain high-mass, low-speed urban public transport vehicles, where the likelihood of a crash situation and the severity thereof are low. Powered and manual wheelchairs offer a large variety of seated postures through their tilt, recline, and other mechanisms. Guidelines ought to be given by manufacturers with respect to use of these mechanisms during transport. The combination of a crashworthy seating system, that accommodates the proper fit of the occupant restraints, and a crashworthy wheelchair serve to indicate to the prescriber that the risks of equipment failure when exposed to crash conditions during transport have been reduced as far as reasonably possible. To minimise injury risk for wheelchair occupants, prescribers shall seek to ensure that the means of attachment of the seating system to the wheelchair is suitable for use in transport. It is imperative that the manufacturer’s instructions for use and fitting instructions for seating systems are carefully adhered to. Due to the individual nature of disability, prescribers may at times be faced with the need to work beyond manufacturers’ recommendations for the use of systems in order to maximise medical benefits, and to address the postural and functional needs of a wheelchair user. In such cases a risk management process ought to be followed, and transport providers should have a working comprehension of the relevant documented risk assessment process and understand the subsequent Risk/Benefit analysis. When properly used, a WTORS allows the wheelchair to be well secured to the vehicle floor and the passenger in the wheelchair to benefit from a properly fitted seatbelt system. Wheelchair manufacturers should highlight in their pre-sale literature any special requirements relating to the use of their wheelchair with WTORS. This information should include the configuration of the representative wheelchair, which was subjected to crash testing, so that informed decisions can be made with respect to wheelchair selection & configuration. Prescriber awareness of the type of transport environment and the facilities available to assist vehicle entry and egress is highly beneficial in the risk analysis process.
  • Argiropoulos, Bob, et al. (författare)
  • Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3.
  • 2008
  • Ingår i: Experimental hematology. - 0301-472X. ; 36:7, s. 845-59
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: MEIS1, a HOX cofactor, collaborates with multiple HOX and NUP98-HOX fusion proteins to accelerate the onset of acute myeloid leukemia (AML) through largely unknown molecular mechanisms. MATERIALS AND METHODS: To further resolve these mechanisms, we conducted a structure-function analysis of MEIS1 and gene-expression profiling, in the context of NUP98-HOXD13 (ND13) leukemogenesis. RESULTS: We show, in a murine bone marrow transplantation model, that the PBX-interaction domain, the homeodomain, and the C-terminal domain of MEIS1, are all required for leukemogenic collaboration with ND13. In contrast, the N-terminal domain of MEIS1 is dispensable for collaboration with ND13, but is required for Flt3 upregulation, indicating additional roles for MEIS1 in induction of leukemia independent of alterations in Flt3 expression. Gene-expression profiling of a cloned ND13 preleukemic cell line transduced with wild-type or Meis1 mutant forms revealed deregulation of multiple genes, including a set not previously implicated as MEIS1 targets. Chromatin immunoprecipitation revealed the in vivo occupancy of MEIS1 on regulatory sequences of Trib2, Flt3, Dlk1, Ccl3, Ccl4, Pf4, and Rgs1. Furthermore, engineered overexpression of Trib2 complements ND13 to induce AML while Ccl3 potentiates the repopulating ability of ND13. CONCLUSION: This study shows that Meis1-induced leukemogenesis with ND13 can occur in the absence of Flt3 upregulation and reveals the existence of other pathways activated by MEIS1 to promote leukemia.
  • Argiropoulos, Bob, et al. (författare)
  • Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3.
  • 2010
  • Ingår i: Blood. - 1528-0020. ; 115:20, s. 4071-82
  • Tidskriftsartikel (refereegranskat)abstract
    • MEIS1 is a three-amino acid loop extension class homeodomain-containing homeobox (HOX) cofactor that plays key roles in normal hematopoiesis and leukemogenesis. Expression of Meis1 is rate-limiting in MLL-associated leukemias and potently interacts with Hox and NUP98-HOX genes in leukemic transformation to promote self-renewal and proliferation of hematopoietic progenitors. The oncogenicity of MEIS1 has been linked to its transcriptional activation properties. To further reveal the pathways triggered by Meis1, we assessed the function of a novel engineered fusion form of Meis1, M33-MEIS1, designed to confer transcriptional repression to Meis1 target genes that are otherwise up-regulated in normal and malignant hematopoiesis. Retroviral overexpression of M33-Meis1 resulted in the rapid and complete eradication of M33-Meis1-transduced normal and leukemic cells in vivo. Cell-cycle analysis showed that M33-Meis1 impeded the progression of cells from G(1)-to-S phase, which correlated with significant reduction of cyclin D3 levels and the inhibition of retinoblastoma (pRb) hyperphosphorylation. We identified cyclin D3 as a direct downstream target of MEIS1 and M33-MEIS1 and showed that the G(1)-phase accumulation and growth suppression induced by M33-Meis1 was partially relieved by overexpression of cyclin D3. This study provides strong evidence linking the growth-promoting activities of Meis1 to the cyclin D-pRb cell-cycle control pathway.
  • Bob, Clifford (författare)
  • What issues rouse global civil society?
  • 2012
  • Ingår i: Global Civil Society : Shifting Powers in a Shifting World. - Uppsala : Uppsala universitet. - 978-91-975741-8-1 ; s. 83-89
  • Bokkapitel (övrigt vetenskapligt)
  • Briscoe, Bob, et al. (författare)
  • Reducing Internet Latency : A Survey of Techniques and Their Merits
  • 2016
  • Ingår i: IEEE Communications Surveys and Tutorials. - IEEE. - 1553-877X. ; 18:3, s. 2149-2196
  • Tidskriftsartikel (refereegranskat)abstract
    • Latency is increasingly becoming a performance bottleneck for Internet Protocol (IP) networks, but historically, networks have been designed with aims of maximizing throughput and utilization. This paper offers a broad survey of techniques aimed at tackling latency in the literature up to August 2014, as well as their merits. A goal of this work is to be able to quantify and compare the merits of the different Internet latency reducing techniques, contrasting their gains in delay reduction versus the pain required to implement and deploy them. We found that classifying techniques according to the sources of delay they alleviate provided the best insight into the following issues: 1) The structural arrangement of a network, such as placement of servers and suboptimal routes, can contribute significantly to latency; 2) each interaction between communicating endpoints adds a Round Trip Time (RTT) to latency, particularly significant for short flows; 3) in addition to base propagation delay, several sources of delay accumulate along transmission paths, today intermittently dominated by queuing delays; 4) it takes time to sense and use available capacity, with overuse inflicting latency on other flows sharing the capacity; and 5) within end systems, delay sources include operating system buffering, head-of-line blocking, and hardware interaction. No single source of delay dominates in all cases, and many of these sources are spasmodic and highly variable. Solutions addressing these sources often both reduce the overall latency and make it more predictable.
  • Carter, Bob, et al. (författare)
  • Nothing gets done and no one knows why : PCS and workplace control of lean in HM revenue and customs
  • 2012
  • Ingår i: Industrial relations journal. - 0019-8692. ; 43:5, s. 416-432
  • Tidskriftsartikel (refereegranskat)abstract
    • This article examines the willingness and capacity of public sector unions to mobilise action against changes in the labour process in order to maintain some measure of control at the point of production. Taking as an instance an extended dispute in Her Majesty's Revenue and Customs over the introduction and impact of Lean processes, it marshals evidence gathered from documentary sources, branch representatives and national lay full-time officers to engage with the notion of a trade union bureaucracy. In taking a union with a left-wing leadership and a section with 80 per cent membership with an expressed willingness to escalate industrial action, the article tests Hyman's 1979 contention that, rather than a concentration on a bureaucratic caste, a much better explanation for conservatism centres on the nature of social relations within the union that encompass a wider layer of representatives.
  • Carter, Bob, et al. (författare)
  • ‘Stressed out of my box’ : employee experience of lean working and occupational ill-health in clerical work in the UK public sector
  • 2013
  • Ingår i: Work, Employment and Society. - 0950-0170. ; 27:5, s. 747-767
  • Tidskriftsartikel (refereegranskat)abstract
    • Occupational health and safety (OHS) is under-researched in the sociology of work and employment. This deficit is most pronounced for white-collar occupations. Despite growing awareness of the significance of psychosocial conditions – notably stress – and musculoskeletal disorders, white-collar work is considered by conventional OHS discourse to be ‘safe’. This study’s locus is clerical processing in the UK public sector, specifically Her Majesty’s Revenue and Customs, in the context of efficiency savings programmes. The key initiative was lean working, which involved redesigned workflow, task fragmentation, standardization and individual targets. Utilizing a holistic model of white-collar OHS and in-depth quantitative and qualitative data, the evidence of widespread self-reported ill-health symptoms is compelling. Statistical tests of association demonstrate that the transformed work organization that accompanied lean working contributed most to employees’, particularly women’s, ill-health complaints
  • Carter, Bob, et al. (författare)
  • Taxing times : lean working and the creation of (in)efficiencies in hm revenue and costums
  • 2013
  • Ingår i: Public Administration. - 0033-3298. ; 91:1, s. 83-97
  • Tidskriftsartikel (refereegranskat)abstract
    • The prevailing economic and budgetary climate is intensifying the search for methods and practices aimed at generating efficiencies in public sector provision. This paper investigates the increasingly popular bundle of techniques operating under the generic descriptor of lean, which promises to improve operational quality processes while simultaneously reducing cost. It offers a critical appraisal of lean as a fashionable component of public sector reform and challenges the received wisdom that it unambiguously delivers ‘efficiencies’. Quantitative and qualitative research in HM Revenue and Customs (HMRC) centred on employees' experiences has indicated the extent to which work has been reorganized along lean principles. However, employees perceive that changes in organizational processes and working practices have unintentionally generated inefficiencies which have impacted on the quality of public service. These suggested outcomes raise wider concerns as lean working is adopted in other public sector organizations.
  • Carter, Bob, et al. (författare)
  • ‘‘They can’t be a buffer any longer’ : Supervisors and class relations under white-collar lean production’
  • 2014
  • Ingår i: Capital and Class. - 0309-8168. ; 38:2, s. 323-343
  • Tidskriftsartikel (refereegranskat)abstract
    • This article reasserts the value of the examination of class relations. It does so via a case study of tax-processing sites within HM Revenue and Customs, focusing on the changes wrought by the alterations to labour and supervisory processes implemented under the banner of ‘lean production’. It concentrates on the transformation of front-line managers, as their tasks moved from those that required tax knowledge and team support to those that narrowed their work towards output monitoring and employee supervision. Following Carchedi, these changes are conceptualised as strengthening the function of capital performed by managers, and weakening their role within the labour process.
  • Carter, Bob, et al. (författare)
  • Uncomfortable truths : teamworking under lean in the UK
  • 2017
  • Ingår i: International Journal of Human Resource Management. - Taylor & Francis. - 0958-5192. ; 28:3, s. 449-467
  • Tidskriftsartikel (refereegranskat)abstract
    • A recent contribution in this journal – Procter, S. and Radnor, Z. (2014) ‘Teamworking under Lean in UK public services: lean teams and team targets in Her Majesty’s Revenue and Customs (HMRC)’ International Journal of Human Resource Management, 25:21, 2978–2995 – provides an account of teamworking in the UK Civil Service, specifically Her Majesty’s Revenue and Customs (HMRC), focused on the relationship between recently implemented lean work organisation and teams and teamworking. Procter and Radnor claim in this work that it delivers a ‘more nuanced’ analysis of lean in this government department and, it follows, of the lean phenomenon more generally. Our riposte critiques their article on several grounds. It suffers from problems of logic and construction, conceptual confusion and definitional imprecision. Methodological difficulties and inconsistent evidence contribute additionally to analytical weakness. Included in our response are empirical findings on teamworking at HMRC that challenge Procter and Radnor’s evidential basis and further reveal the shortcomings of their interpretation
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