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Träfflista för sökning "WFRF:(Andersson Irene) "

Sökning: WFRF:(Andersson Irene)

  • Resultat 1-10 av 63
  • [1]234567Nästa
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  • Andersson, Frida, et al. (författare)
  • Avslutning: Geografi på den politiska agendan
  • 2008
  • Ingår i: Regionalpolitikens geografi. Regional tillväxt i teori och praktik. - Studentlitteratur. - 978-91-44-01541-5 ; s. 285-291
  • Bokkapitel (övrigt vetenskapligt)
  • Akimoto, Chizuru, et al. (författare)
  • No GGGGCC-hexanucleotide repeat expansion in C9ORF72 in parkinsonism patients in Sweden
  • 2013
  • Ingår i: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. - Informa Healthcare. - 2167-8421. ; 14:1, s. 26-29
  • Tidskriftsartikel (refereegranskat)abstract
    • An intronic GGGGCC-hexanucleotide repeat expansion in C9ORF72 was recently identified as a major cause of amyotrophic lateral sclerosis and frontotemporal dementia. Some amyotrophic lateral sclerosis patients have signs of parkinsonism, and many parkinsonism patients develop dementia. In this study we examined if the hexanucleotide repeat expansion was present in parkinsonism patients, to clarify if there could be a relationship between the repeat expansion and disease. We studied the size of the hexanucleotide repeat expansion in a well defined population-based cohort of 135 Parkinson's disease patients and 39 patients with atypical parkinsonism and compared with 645 Swedish control subjects. We found no correlation between Parkinson's disease or atypical parkinsonism and the size of the GGGGCC repeat expansion in C9ORF72. In conclusion, this GGGGCC-repeat expansion in C9ORF72 is not a cause of parkinsonism in the Swedish population.
  • Alexeyev, Oleg A, et al. (författare)
  • Direct visualization of Propionibacterium acnes in prostate tissue by multicolor fluorescent in situ hybridization assay.
  • 2007
  • Ingår i: Journal of Clinical Microbiology. - 0095-1137. ; 45:11, s. 3721-8
  • Tidskriftsartikel (refereegranskat)abstract
    • Prostate tissues from patients with prostate cancer and benign prostatic hyperplasia (BPH) frequently contain histological inflammation, and a proportion of these patients show evidence of Propionibacterium acnes infection in the prostate gland. We developed a multicolor fluorescent in situ hybridization (FISH) assay targeting P. acnes 23S rRNA along with a 14-kb region of the P. acnes genome. This assay was used to analyze prostate tissues from patients with prostate cancer and BPH. P. acnes infection of the prostate gland was demonstrated in prostatic tissue in 5 of 10 randomly selected prostate cancer patients. FISH analysis and confocal laser microscopy imaging revealed intracellular localization and stromal biofilm-like aggregates as common forms of P. acnes infection in prostate tissues from both prostate cancer and BPH patients. A sequential analysis of prostate tissue from individual patients suggested that P. acnes can persist for up to 6 years in the prostate gland. These results indicate that P. acnes can establish a persistent infection in the prostate gland. Further study is needed to clarify the link between this bacterium and prostatic inflammation which may contribute to the development of BPH and prostate cancer.
  • Anderson, Leif G, 1951-, et al. (författare)
  • Source and formation of the upper halocline of the Arctic Ocean
  • 2013
  • Ingår i: Journal of Geophysical Research - Oceans. - 0148-0227. ; 118:1, s. 410-421
  • Tidskriftsartikel (refereegranskat)abstract
    • The upper halocline of the Arctic Ocean has a distinct chemical signature with high nutrient concentrations as well as low oxygen and pH values. This signature is formed in the Chukchi and East Siberian Seas, by a combination of mineralization of organic matter and release of decay products to the sea ice brine enriched bottom water. Salinity and total alkalinity data show that the fraction of sea ice brine in the nutrient enriched upper halocline water in the central Arctic Ocean is up to 4%. In the East Siberian Sea the bottom waters with exceptional high nutrient concentration and low pH have typically between 5 and 10% of sea ice brine as computed from salinity and oxygen-18 values. On the continental slope, over bottom depths of 15-200 m, the brine contribution was 6% at the nutrient maximum depth (50-100 m). At the same location as well as over the deeper basin the silicate maximum was found over a wider salinity range than traditionally found in the Canada Basin, in agreement with earlier observations east of the Chukchi Plateau. A detailed evaluation of the chemical and the temperature-salinity properties suggests at least two different areas for the formation of the nutrient rich halocline within the East Siberian Sea. This has not been observed before 2004 and it could be a sign of a changing marine climate in the East Siberian Sea, caused by more open water in the summer season followed by more sea ice formation and brine production in the fall/winter.
  • Andersson, Frida, et al. (författare)
  • Geografi på den politiska agendan
  • 2008
  • Ingår i: Regionalpolitikens geografi: regional tillväxt i teori och praktik. - Lund : Studentlitteratur. - 978-91-44-01541-5 ; s. 285-292
  • Bokkapitel (övrigt vetenskapligt)
  • Andersson, Frida, et al. (författare)
  • Introduktion: En regional politik i förändring
  • 2008
  • Ingår i: Regionalpolitikens geografi. Regional tillväxt i teori och praktik. - Studentlitteratur. - 978-91-44-01541-5 ; s. 7-34
  • Bokkapitel (övrigt vetenskapligt)
  • Andersson, Frida, et al. (författare)
  • Regionalisering och skalpolitik
  • 2008
  • Ingår i: Regionalpolitikens geografi : regional tillväxt i teori och praktik. - Lund : Studentlitteratur. - 978-91-44-01541-5 ; s. 115-138
  • Bokkapitel (övrigt vetenskapligt)
  • Andersson, Irene, 1978- (författare)
  • Cardiovascular effects of growth hormone. Studies in genetically engineered mice
  • 2004
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • The general aim of this thesis was to enhance the understanding on the relationships between growth hormone (GH) and cardiovascular disease using genetically engineered mice. More specifically the effects of GH on blood pressure (BP), vascular and cardiac function, atherosclerosis and autonomic control of heart rate were studied. Two genetically engineered mice models were used, bovine GH transgenic (bGH) and GH receptor/binding protein knock-out mice (GHR KO). In addition a third mouse model was generated through crossbreeding of bGH and an atherosclerosis prone mouse strain, apoE-/-, yielding apoE-/-/bGH mice. bGH mice had increased mean arterial BP compared to control mice as measured by telemetry. The hypertension was not salt sensitive but associated with increased resistance of the hindquarter vasculature. Mesenteric arteries from bGH mice displayed intact endothelial function and decreased sensitivity to noradrenaline, as assessed by myograph technique, while carotid artery and aorta displayed impaired endothelial function. Treatment of the vessels with a super oxide dismutase (SOD) mimetic appeared to abolish differences in endothelium dependent vasodilation between bGH and control mice. However, aorta from young bGH mice had intact endothelial function accompanied by increased mRNA levels of SOD and endothelial nitric oxide synthase, semi quantified by real-time PCR. Heart rate responses measured by telemetry, to pharmacological challenging of the sympathetic and parasympathetic nervous system, showed that bGH mice had reduced ability for sympathetic activation but intact reflex activation of parasympathetic nervous system. bGH mice also had decreased heart rate variability and reduced noradrenaline concentrations in plasma and tissue, measured by high performance liquid chromatography. Systolic BP, measured by tail-cuff technique, was increased in female apoE-/-/bGH mice compared to apoE-/- control mice. Atherosclerotic plaque area in the thoracic aorta, quantified en face after lipid staining, was significantly increased in male apoE-/-/bGH compared to control, and tended to be increased in female apoE-/-/bGH. Interestingly, female apoE-/-/bGH had a more atherogenic serum lipid profile than male. Finally, GHR KO mice had decreased systolic BP measured by tail-cuff technique and reduced cardiac and vascular structure but intact endothelial function. Furthermore, GHR KO mice had impaired cardiac function as assessed by echocardiography. In summary, this thesis has generated new knowledge on the effects of GH on cardiovascular function and development of atherosclerosis. It has presented a novel mouse model that facilitates direct studies on the mechanism involved in GH induced atherogenesis. A further important finding is that GH appears to have profound effects on sympathetic nervous system function and tissue noradrenaline levels. This may be an interesting future target for treatment of diseases associated with autonomic dysfunction.
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