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Sökning: WFRF:(Pagels Joakim)

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1.
  • Ali, Neserin, et al. (författare)
  • Comprehensive proteome analysis of nasal lavage samples after controlled exposure to welding nanoparticles shows an induced acute phase and a nuclear receptor, LXR/RXR, activation that influence the status of the extracellular matrix
  • 2018
  • Ingår i: Clinical Proteomics. - Humana Press. - 1542-6416. ; 15:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Epidemiological studies have shown that many welders experience respiratory symptoms. During the welding process a large number of airborne nanosized particles are generated, which might be inhaled and deposited in the respiratory tract. Knowledge of the underlying mechanisms behind observed symptoms is still partly lacking, although inflammation is suggested to play a central role. The aim of this study was to investigate the effects of welding fume particle exposure on the proteome expression level in welders suffering from respiratory symptoms, and changes in protein mediators in nasal lavage samples were analyzed. Such mediators will be helpful to clarify the pathomechanisms behind welding fume particle-induced effects. Methods: In an exposure chamber, 11 welders with work-related symptoms in the lower airways during the last month were exposed to mild-steel welding fume particles (1 mg/m3) and to filtered air, respectively, in a double-blind manner. Nasal lavage samples were collected before, immediately after, and the day after exposure. The proteins in the nasal lavage were analyzed with two different mass spectrometry approaches, label-free discovery shotgun LC-MS/MS and a targeted selected reaction monitoring LC-MS/MS analyzing 130 proteins and four in vivo peptide degradation products. Results: The analysis revealed 30 significantly changed proteins that were associated with two main pathways; activation of acute phase response signaling and activation of LXR/RXR, which is a nuclear receptor family involved in lipid signaling. Connective tissue proteins and proteins controlling the degradation of such tissues, including two different matrix metalloprotease proteins, MMP8 and MMP9, were among the significantly changed enzymes and were identified as important key players in the pathways. Conclusion: Exposure to mild-steel welding fume particles causes measurable changes on the proteome level in nasal lavage matrix in exposed welders, although no clinical symptoms were manifested. The results suggested that the exposure causes an immediate effect on the proteome level involving acute phase proteins and mediators regulating lipid signaling. Proteases involved in maintaining the balance between the formation and degradation of extracellular matrix proteins are important key proteins in the induced effects.
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  • Bladh, Henrik, et al. (författare)
  • Influence of Soot Particle Aggregation on Time-Resolved Laser-Induced Incandescence Signals
  • 2011
  • Ingår i: Applied Physics B. - Springer. - 0946-2171. ; 104:2, s. 331-341
  • Tidskriftsartikel (refereegranskat)abstract
    • Laser-induced incandescence (LII) is a versatile technique for quantitative soot measurements in flames and exhausts. When used for particle sizing, the time-resolved signals are analysed as these will show a decay rate dependent on the soot particle size. Such an analysis has traditionally been based on the assumption of isolated primary particles. However, soot particles in flames and exhausts are usually aggregated, which implies loss of surface area, less heat conduction and hence errors in estimated particle sizes. In this work we present an experimental investigation aiming to quantify this effect. A soot generator, based on a propane diffusion flame, was used to produce a stable soot stream and the soot was characterised by transmission electron microscopy (TEM), a scanning mobility particle sizer (SMPS) and an aerosol particle mass analyzer coupled in series after a differential mobility analyzer (DMA-APM). Despite nearly identical primary particle size distributions for three selected operating conditions, LII measurements resulted in signal decays with significant differences in decay rate. However, the three cases were found to have quite different levels of aggregation as shown both in TEM images and mobility size distributions, and the results agree qualitatively with the expected effect of diminished heat conduction from aggregated particles resulting in longer LII signal decays. In an attempt to explain the differences quantitatively, the LII signal dependence on aggregation was modelled using a heat and mass transfer model for LII given the primary particle and aggregate size distribution data as input. Quantitative agreement was not reached and reasons for this discrepancy are discussed.
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