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NumreringReferensOmslagsbildHitta
238591.
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238592.
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238593.
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238594.
  • Rosenbaum, Larry, 1949- (författare)
  • Post-traumatic stress disorder : The chameleon of psyhiatry
  • 2004
  • Ingår i: Nordic Journal of Psychiatry. - 0803-9488 .- 1502-4725. ; 58:5, s. 343-348
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Post-traumatic stress disorder (PTSD) has been included in the DSM category of psychiatric diagnoses since 1980, classified as an anxiety disorder. Since that time, its definition has undergone considerable change and today many physicians are not aware of its current diagnostic criteria or the clinical significance of its high degree of comorbidity with other psychiatric and somatic conditions. PTSD can appear in different forms, and its many manifestations often identified and dealt with, while the underlying pathological trauma and psychological damage continues unrecognized and untreated, resulting in negative consequences for the patient and society. The extent of the problem is considerable in North America but prevalence studies in Europe are practically non-existent amongst the general population, with the subsequent result being that the degree and severity of the problem in Europe remains unknown. This article briefly looks at the history and metamorphosis of PTSD and discusses its present niche in relation to primary healthcare.</p>
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238595.
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238596.
  • Rosenbaum, P., et al. (författare)
  • A report: the definition and classification of cerebral palsy April 2006
  • 2007
  • Ingår i: Dev Med Child Neurol Suppl. - 0419-0238 (Print). ; 109, s. 8-14
  • Tidskriftsartikel (refereegranskat)abstract
    • For a variety of reasons, the definition and the classification of cerebral palsy (CP) need to be reconsidered. Modern brain imaging techniques have shed new light on the nature of the underlying brain injury and studies on the neurobiology of and pathology associated with brain development have further explored etiologic mechanisms. It is now recognized that assessing the extent of activity restriction is part of CP evaluation and that people without activity restriction should not be included in the CP rubric. Also, previous definitions have not given sufficient prominence to the non-motor neurodevelopmental disabilities of performance and behaviour that commonly accompany CP, nor to the progression of musculoskeletal difficulties that often occurs with advancing age. In order to explore this information, pertinent material was reviewed on July 11-13, 2004 at an international workshop in Bethesda, MD (USA) organized by an Executive Committee and participated in by selected leaders in the preclinical and clinical sciences. At the workshop, it was agreed that the concept 'cerebral palsy' should be retained. Suggestions were made about the content of a revised definition and classification of CP that would meet the needs of clinicians, investigators, health officials, families and the public and would provide a common language for improved communication. Panels organized by the Executive Committee used this information and additional comments from the international community to generate a report on the Definition and Classification of Cerebral Palsy, April 2006. The Executive Committee presents this report with the intent of providing a common conceptualization of CP for use by a broad international audience.
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238597.
  • Rosenberg, A., et al. (författare)
  • Multidomain Interventions to Prevent Cognitive Impairment, Alzheimer's Disease, and Dementia : From FINGER to World-Wide FINGERS
  • 2020
  • Ingår i: The Journal of Prevention of Alzheimer's Disease. - 2274-5807 .- 2426-0266. ; 7:1, s. 29-36
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Alzheimer's disease (AD) and dementia are a global public health priority, and prevention has been highlighted as a pivotal component in managing the dementia epidemic. Modifiable risk factors of dementia and AD include lifestyle-related factors, vascular and metabolic disorders, and psychosocial factors. Randomized controlled clinical trials (RCTs) are needed to clarify whether modifying such factors can prevent or postpone cognitive impairment and dementia in older adults. Given the complex, multifactorial, and heterogeneous nature of late-onset AD and dementia, interventions targeting several risk factors and mechanisms simultaneously may be required for optimal preventive effects. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is the first large, long-term RCT to demonstrate that a multidomain lifestyle-based intervention ameliorating vascular and lifestyle-related risk factors can preserve cognitive functioning and reduce the risk of cognitive decline among older adults at increased risk of dementia. To investigate the multidomain intervention in other populations and diverse cultural and geographical settings, the World-Wide FINGERS (WW-FINGERS) network was recently launched (). Within this network, new FINGER-type trials with shared core methodology, but local culture and context-specific adaptations, will be conducted in several countries. The WW-FINGERS initiative facilitates international collaborations, provides a platform for testing multidomain strategies to prevent cognitive impairment and dementia, and aims at generating high-quality scientific evidence to support public health and clinical decision-making. Furthermore, the WW-FINGERS network can support the implementation of preventive strategies and translation of research findings into practice.</p>
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238598.
  • Rosenberg, Anna, et al. (författare)
  • Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics The FINGER trial
  • 2018
  • Ingår i: Alzheimer's & Dementia. - New York : Elsevier. - 1552-5260 .- 1552-5279. ; 14:3, s. 263-270
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Introduction: The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition. Methods: The FINGER recruited 1260 people from the general Finnish population (60-77 years, at risk for dementia). Participants were randomized 1: 1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants' characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses. Results: Sociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini-Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction &gt; .05). Conclusions: The FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia.</p>
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238599.
  • Rosenberg, Anna, et al. (författare)
  • Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics The FINGER trial
  • 2018
  • Ingår i: Alzheimer's & Dementia. - Elsevier. - 1552-5260 .- 1552-5279. ; 14:3, s. 263-270
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Introduction: The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition.</p><p>Methods: The FINGER recruited 1260 people from the general Finnish population (60-77 years, at risk for dementia). Participants were randomized 1: 1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants' characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses.</p><p>Results: Sociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini-Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction &gt; .05). Conclusions: The FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia. </p>
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238600.
  • Rosenberg, Anna, et al. (författare)
  • Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics : The FINGER trial
  • 2018
  • Ingår i: Alzheimer's & Dementia. - 1552-5260 .- 1552-5279. ; 14:3, s. 263-270
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>Introduction</strong>: The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition.</p><p><strong>Methods</strong>: The FINGER recruited 1260 people from the general Finnish population (60-77 years, at risk for dementia). Participants were randomized 1: 1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants' characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses.</p><p><strong>Results</strong>: Sociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini-Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction &gt; .05).</p><p><strong>Conclusions</strong>: The FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia.</p>
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