| 238601. |
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| 238602. |
- Rung, Lena, et al.
(författare)
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Three-year follow-up of visual outcome and quality of life in patients with age-related macular degeneration
- 2013
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Ingår i: Clinical Ophthalmology. - 1177-5467. ; 7, s. 395-401
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Tidskriftsartikel (refereegranskat)abstract
- Background: The purpose of this study was to evaluate the visual outcome and self-reported vision-targeted health status in patients treated with intravitreal ranibizumab for wet age-related macular degeneration (AMD). Methods: A total of 51 eyes from 50 patients aged 76 ± 7 years, with wet AMD not previously treated, were included in this prospective study. Best corrected visual acuity was examined using Early Treatment Diabetic Research Study charts and near vision reading. All patients underwent an ophthalmological examination, including fluorescein and indocyanine green angiography (occult cases) and optical coherence tomography. The Visual Function Questionnaire test was completed before and 37 ± 7 months after the start of intravitreal injections. Results: The patients received a mean number of 7.8 ± 5.0 (range 2-22) injections. One month after the third intravitreal injection, significant improvement was seen in both visual acuity (53 ± 14 to 61 ± 14 letter, P = 0.001) and near vision (17 ± 9 to 11 ± 8 points, P = 0.001). During follow-up, mean visual acuity decreased from 53 ± 14 to 44 ± 24 letters (P = 0.011), and near vision decreased from 17 ± 9 to 20 ± 11 points (P = 0.048). Despite visual impairment, the quality of life test revealed no significant decrease in mental health (P = 0.529) or ability to read a newspaper (P = 0.21), but a decrease in distance activities (reading street signs, steps, going to the theater) from 57 ± 27 to 46 ± 31 points (P = 0.007) was documented. Conclusion: Decreased visual acuity was related to a decrease in self-reported visual function for distance activities, while mental health items, such as worrying, were not influenced.
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| 238603. |
- Runge, N., et al.
(författare)
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The effectiveness of exercise and physical activity programs on fatigue and sleep in people with arthritis - A systematic review with meta-analysis
- 2023
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Ingår i: SLEEP MEDICINE REVIEWS. - 1087-0792 .- 1532-2955. ; 71
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Tidskriftsartikel (refereegranskat)abstract
- This systematic review aimed to systematically investigate the literature on the effectiveness of exercise and physical activity programs on fatigue and sleep in people with arthritis. For that, seven databases were searched for relevant randomized controlled trials. After the searches, 36 studies investigating 2281 participants were included. Risk of bias assessments were done by two independent reviewers using the Cochrane Risk of Bias tool 2. Random-effects meta-analyses were performed, and the Grading of Recommendations Assessment, Development and Evaluation framework was used to judge the certainty of evidence. The evidence on benefits of exercise and physical activity programs on fatigue and sleep parameters in people with osteoarthritis and psoriatic arthritis was either lacking or inconclusive. There was very low to low certainty evidence for a slight benefit of exercise and physical activity programs on fatigue at short-term in people with ankylosing spondylitis and rheumatoid arthritis. However, the evidence was very uncertain for the medium- and long-term as well as for any sleep parameters. The results indicate that exercise and physical activity programs may offer some benefits on fatigue for people with arthritis in the short-term, although the best type of exercise remains uncertain. The available evidence on improvements in sleep was insufficient to draw strong conclusions.
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| 238604. |
- Rungtanakiat, Piboon, et al.
(författare)
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Association of Peri-Implant Mucosa Dimensions With Emergence Profile Angles of the Implant Prosthesis
- 2024
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Ingår i: Clinical and Experimental Dental Research. - : John Wiley & Sons. - 2057-4347. ; 10:4
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Tidskriftsartikel (refereegranskat)abstract
- Objectives The primary aim of this cross-sectional study was to investigate the association between prosthesis design and peri-implant mucosa dimensions and morphology. The secondary aim was to investigate associations between mucosal dimensions and the presence of mucositis. Materials and Methods Forty-seven patients with 103 posterior bone level implants underwent clinical and radiographic examination, including cone beam computer tomography and intraoral optical scanning. Three-dimensional models for each implant and peri-implant mucosa were constructed. Vertical mucosa height (TH), horizontal mucosa width at implant platform (TW), and 1.5 mm coronal of the platform (TW1.5), as well as mucosal emergence angle (MEA), deep angle (DA), and total contour angle (TA) were measured at six sites for each implant. Results There was a consistent correlation between peri-implant mucosa width and height (beta = 0.217, p < 0.001), with the width consistently surpassing height by a factor of 1.4-2.1. All three angles (MEA, DA, TA) were negatively associated with mucosa height (p < 0.001), while DA was negatively associated with mucosa width (TW1.5) (p < 0.001, beta = -0.02, 95% CI: -0.03, -0.01). There was a significant negative association between bleeding on probing (BoP) and mucosa width at platform (OR 0.903, 95% CI: 0.818-0.997, p = 0.043) and 1.5 coronal (OR 0.877, 95% CI: 0.778-0.989, p = 0.033). Implants with less than half sites positive for BoP (0-2/6) had significantly higher mucosa height (OR 3.51, 95% CI: 1.72-7.14, p = 0.001). Conclusions Prosthesis design can influence the dimensions of the peri-implant mucosa, with wider emergence profile angles associated with reduced peri-implant mucosa height. In particular, a wider deep angle is associated with reduced mucosa width in posterior sites. Reduced peri-implant mucosa height and width are associated with more signs of inflammation.
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| 238605. |
- Rungtanakiat, Piboon, et al.
(författare)
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Association of prosthetic angles of the Implant Supracrestal Complex with peri-implant tissue mucositis
- 2023
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Ingår i: Clinical and Experimental Dental Research. - : John Wiley & Sons. - 2057-4347. ; 9:3, s. 425-436
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Tidskriftsartikel (refereegranskat)abstract
- ObjectivesThe aim of this study was to investigate the association of the Mucosal Emergence Angle (MEA) with peri-implant tissue mucositis. Material and MethodsForty-seven patients with 103 posterior bone level implants underwent clinical and radiographic examination. Three-dimensional data from Cone Bean Computer Tomography and Optica Scan were transposed. Three angles were defined: MEA, Deep Angle (DA) and Total Angle (TA) and measured at six sites for each implant. ResultsThere was a significant correlation between MEA and Bleeding on Probing for all sites with an overall odds ratio of odd ratio 1.07 (95% confidence interval [CI] 1.05-1.09, p < 0.001). Sites with MEA >= 30 degrees, 40 degrees, 50 degrees, 60 degrees, and 70 degrees had a higher risk for bleeding with an odds ratio of 3.1, 5, 7.5, 11.4 and 33.55, respectively. When all 6 sites of an implant prostheses had MEA >= 40 degrees, the risk of having bleeding at all 6 sites was 9.5 times higher (95% CI 1.70-52.97, p = 0.010). ConclusionsMaintaining MEA no wider than 30 degrees-40 degrees is advisable, while the aim should be to keep this angle as narrow as clinically feasible. Registered in Thai Clinical Trials Registry: http://www.thaiclinicaltrials.org/show/TCTR20220204002
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| 238606. |
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| 238607. |
- Runnerstam, Magnus, 1959
(författare)
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Monitoring of extracellular substances after spontaneous and experimental subarachnoid hemorrhage
- 2000
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Even though survival is considerably enhanced after surgical treatment of an aneurysmal subarachnoid hemorrhage (SAH), there is a critical period, which keeps the patient in intensive care for days or even weeks. Complications, such as vasospasm, ischemia and brain edema ultimately lead to further brain damage.The introduction of microdialysis allows regional monitoring of the cerebral extracellular fluid (ECF) for levels of metabolites and marker substances, which may predict development of various complications. However, the results are often difficult to interpret due to the heterogeneity of the patient groups. This thesis addresses the question of whether it is possible to follow courses of events after SAH by monitoring the cerebral ECF with respect to molecules of prognostic value. A model was developed for SAH (I), which compares the effects of blood and of increased ICP. The deleterious effects were mainly ascribed to blood in the subarachnoid fluid.Traumatic SAH (tSAH) is the most common type and is similar to spontaneous SAH with respect to secondary effects, such as vasospasm. Rotational acceleration of the head provides extensive tSAH (II). Glutamate and glycine increased in the hippocampal ECF in agreement with (I), but in addition, the trauma caused increased taurine and GABA. In contrast, aspartate, alanine and serine were less affected than after spontaneous SAH. Extensive neuronal loss occured in the tSAH model, both in the cerebral cortex, hippocampus and cerebellum, an effect interpreted to have a causal relationship with the high concentrations of excitatory amino acids in the ECF. A disadvantage of the tSAH model was the difficulty to distinguish effects of the hemorrhage and of the trauma per se.Seizures, caused by exposition of brain tissue to extravascular blood for a prolonged time, are common after SAH. Breakdown products of hemoglobin have been proposed as causes, paticularly after repeated bleedings. An obvious model for this question are cavernous angiomas (CA), a form of vascular malformations. The main symptoms are seizures, which often disappear upon the excision of the CA. Excised CAs from 10 patients were characterized biochemically (III). Iron and GFAP were markedly elevated in the angiomas as well as in the surrounding gliotic tissue. In the gliotic tissue, the concentrations of glycine and glutamine were increased, but that of GABA decreased.In two clinical studies with microdialysis sampling, SAH patients were operated with clip ligatures of ruptured arterial intracranial aneurysms. Neurotransmitter amino acids and other amino acids, as well as the glial marker protein GFAP were analyzed. The level of total amino acids in the ECF appeared to be higher in patients with low levels of consciousness (IV). Transient elevations of taurine and also of glycine and serine were more frequent than increases of the excitatory amino acids glutamate and aspartate (IV). The concentration of GFAP was higher in the ECF close to the site of the ruptured aneurysm. Specific changes in the concentrations of GFAP also coincided with events such as increased intracranial pressure (ICP), vasospasm and ischemia.
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| 238608. |
- Ruohoalho, J., et al.
(författare)
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Systematic review of tonsil surgery quality registers and introduction of the Nordic Tonsil Surgery Register Collaboration
- 2018
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Ingår i: European Archives of Oto-Rhino-Laryngology. - : Springer Science and Business Media LLC. - 0937-4477 .- 1434-4726. ; 275:6, s. 1353-1363
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Forskningsöversikt (refereegranskat)abstract
- Surgical quality registers provide tools to measure and improve the outcome of surgery. International register collaboration creates an opportunity to assess and critically evaluate national practices, and increases the size of available datasets. Even though millions of yearly tonsillectomies and tonsillotomies are performed worldwide, clinical practices are variable and inconsistency of evidence regarding the best clinical practice exists. The need for quality improvement actions is evident. We aimed to systematically investigate the existing tonsil surgery quality registers found in the literature, and to provide a thorough presentation of the planned Nordic Tonsil Surgery Register Collaboration. A systematic literature search of MEDLINE and EMBASE databases (from January 1990 to December 2016) was conducted to identify registers, databases, quality improvement programs or comprehensive audit programs addressing tonsil surgery. We identified two active registers and three completed audit programs focusing on tonsil surgery quality registration. Recorded variables were fairly similar, but considerable variation in coverage, number of operations included and length of time period for inclusion was discovered. Considering tonsillectomies and tonsillotomies being among the most commonly performed surgical procedures in otorhinolaryngology, it is surprising that only two active registers could be identified. We present a Nordic Tonsil Surgery Register Collaboration-an international tonsil surgery quality register project aiming to provide accurate benchmarks and enhance the quality of tonsil surgery in Denmark, Finland, Norway and Sweden.
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| 238609. |
- Ruokolainen, Olli, et al.
(författare)
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Construct validity and reliability of Finnish version of Orebro Musculoskeletal Pain Screening Questionnaire
- 2016
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Ingår i: Scandinavian Journal of Pain. - : Elsevier. - 1877-8860 .- 1877-8879. ; 13, s. 148-153
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Chronic pain causes suffering for affected individuals and incurs costs to society through work disability. Interventions based on early screening of psychological risk factors for chronic pain using screening tools such as the Orebro Musculoskeletal Pain Screening Questionnaire (OMPSQ) have been found to reduce work absenteeism and health care visits and increase perceived health. The aim of the current study was to translate the OMPSQ into Finnish and test its validity and reliability in a patient sample.Methods: The OMPSQ was forward-backward translated and cross-culturally adapted, and applied to our study population (n = 69), the members of which had been referred to the Department of Physical and Rehabilitation Medicine of Oulu University Hospital from primary health care centres in Northern Finland due to chronic low back pain. The patients answered the OMPSQ two weeks before the hospital visit, and the follow-up questionnaire either during the hospital visit, or after by mail. The reliability of the OMPSQ was evaluated using intraclass correlation coefficients (ICC). Factor analysis was used to group items of the OMPSQ, and internal consistency between the items was determined by calculating Cronbach's alphas.Results: The cross-cultural adaptation revealed only minor semantic and cultural differences. Measurements showed reliability as moderate to nearly perfect for all of the OMPSQ items (ICC values ranged from 0.59 to 0.96). Items loaded into five different factors: disability, psychological symptoms, pain, fear avoidance, and work. All except one (work) showed acceptable internal consistency. The OMPSQ score was positively associated with both intensity of pain and the Oswestry Disability Index.Conclusions and implications: The reliability and construct validity of the Finnish version of the OMPSQ were good. The predictive ability of the OMPSQ in the Finnish population should be evaluated in further studies. (C) 2016 Scandinavian Association for the Study of Pain.
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| 238610. |
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