| 11. |
|
|
| 12. |
|
|
| 13. |
- Olsson, H., et al.
(författare)
-
Relief of Pruritus as an Early Sign of Spinal Cord Compression in Hodgkin's Disease
- 1979
-
Ingår i: Journal of Internal Medicine. - : Wiley. - 0001-6101. ; 206:1-6, s. 319-320
-
Tidskriftsartikel (refereegranskat)abstract
- ABSTRACT In a patient with advanced Hodgkin's disease (HD) associated with generalized pruritus, an unexpected relief of itching was found to be an early sign of spinal cord compression. Following irradiation of an extradural mass at the Th II level, itching recurred. Although the mechanisms bringing about itching in HD are unknown, the relief and recurrence of the symptom in our patient are in line with a peripheral origin of pruritus in the disease. Spontaneous relief of pruritus in HD despite other signs of active disease should prompt a neurological examination, since early recognition and treatment of spinal cord compression in lymphoma are important to avoid residual neurological disability. 1979 Association for the Publication of the Journal of Internal Medicine
|
|
| 14. |
- Steele, G., et al.
(författare)
-
Absorption of blocking activity from human tumor‐bearer sera by staphylococcus aureus, cowan I
- 1975
-
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 15:2, s. 180-189
-
Tidskriftsartikel (refereegranskat)abstract
- Staphylococcus aureus, strain Cowan I, contains a cell‐wall substance, protein A, which combines with the Fc part of IgG in most mammalian species. It can therefore be used as a solid‐phase immunoabsorbant for elimination of the reacting immunoglobulins. Since it has been shown that Cowan I could absorb out the blocking activity of sera from rats bearing isografts of polyoma‐virus‐induced sarcomas or chemically induced colon carcinomas, we investigated what effects Cowan I absorption of human tumor‐bearer sera might have. In all tumor‐bearer sera tested, from patients with melanomas or colon carcinomas, treatment with protein‐A‐containing staphylococci decreased the sera's ability to inhibit lymphocyte‐mediated cytotoxicity in vitro. Cowan‐I‐treated sera from healthy controls had no effect on lymphocyte cytotoxicity. Nor did Cowan‐I‐treated tumor‐bearer sera potentiate or „arm” normal lymphocytes against tumor target cells. There was no evidence of complement‐dependent cytotoxicity with added human complement in sera from melanoma and colon carcinoma bearing patients either before or after absorption with Staphylococcus aureus, Cowan I. The concentrations of IgA, IgG and IgM were determined in sera used for in vitro tests of blocking activity and complement‐dependent cytotoxicity before and after absorption. No reduction of IgA, reduction to undetectable levels of IgG and 20–30% reduction of IgM immunoglobulins as compared to unabsorbed sera were demonstrated.
|
|
| 15. |
- Troye-Blomberg, Marita
(författare)
-
In vitro studies of natural and tumor-associated immunity in patients with transitional cell carcinoma of the urinary bladder
- 1979
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Peripheral blood lymphocytes (PBL) from patients with transitional cell carcinoma of the urinary bladder (TCC-bladder) were studied using a SlCr-release assay for their in vitro cytotoxicity against a panel of allogeneic tissue culture cell lines of TCC-bladder and other origins. Control PBL were obtained from four different groups of donors. Individual donor's lymphocytes frequently displayed cytotoxicity to any one of the target cells. However, PBL from each of the three TCC-bladder groups had strongly elevated mean cytotoxicity to the TCC-bladder targets as compared to that to the control targets. The control groups did not show this. The mean cytotoxicity of PBL from the TCC bladder groups to the bladder tumor targets was significantly higher than that of the control groups. The results suggest the existence of a disease related reactivity in TCC-bladder superimposed on background of natural cytotoxicity. Effector cell studies in allogeneic lymphocyte/tumor target combinations revealed that the cytotoxic effector cells within all donor groups were indistinguishable from the lymphocytes responsible for antibody-dependent cellular cytotoxicity (ADCC, K-cells). A possible involvement of antibodies in the cytotoxic reactions was studied by adding Fab-fragments of anti-human immunoglobulin antibodies (Fab-alg) to the PBL/target cell mixtures. These reagents inhibited cytotoxicity, although inhibition was usually incomplete. The results suggest the involvement of both antibody dependent and antibody independent mechanisms in the cell-mediated cytotoxicity (CMC) against allogeneic target cells. Investigations of effector cell mechanisms in autologous PBL/tumor target combinations revealed the presence of other mechanisms than seen in most allogeneic combinations. Thus, the effector cells were distinct from K-cells and the reactions were not inhibited by the presence of Fab-alg. The results suggest that these autologous reactions may be mediated by antibody independent cytolytic T-lymphocytes (CTL) and may require HLA-compatibility between effector cells and target cells. However, at the present stage, alternative explanations must also be considered. In the search for humoral antibodies to tumor cells in serum of TCC-bladder patients and controls an ADCC assay was used. To avoid inhibition by blocking factors present in whole serum, IgG-fractions were prepared. ADCC inducing antibodies were found in IgG-fractions from both TCC-bladder patients and controls. However, when tested against one cell line of TCC-bladder origin and one control cell line, the IgG-fractions from TCC-bladder patients were on the average more cytotoxic to the TCC-bladder target than to the control. This was not seen with the IgG-fractions of the controls. This suggests that TCC-bladder patients develop a humoral response related to their disease. However, the nature of the antigen(s), responsible for these reactions remains to be established.
|
|
| 16. |
- Turesson, I, et al.
(författare)
-
Non-secretory or low-secretory myeloma with intracellular kappa chains. Report of six cases and review of the literature
- 1978
-
Ingår i: Acta Medica Scandinavica. - : Wiley. - 0001-6101. ; 204:6, s. 51-445
-
Tidskriftsartikel (refereegranskat)abstract
- This report concerns six cases of multiple myeloma characterized by either no demonstrable monoclonal immunoglobulin in plasma or urine or by trace amounts (less than or equal to 0.1 g/l) of monoclonal kappa chains in the urine. In all cases there was an infiltration of the bone marrow by plasma cells containing kappa chains but no heavy chains. A retrospective analysis was made of 126 consecutive cases of Bence Jones myeloma. The number of kappa and lambda cases was approximately the same. All cases secreting less than or equal to 0.1 g light chains per 1 urine were of kappa type. This contrasts with a kappa/lambda ratio of 1.4-1.9 among reported series of M-components containing both heavy and light chains. A review of reported cases of non-secretory myeloma revealed a preserved capacity for Ig synthesis in the majority of cases and among these a preponderance of kappa chain producing clones. These observations might be explained by a higher tendency for kappa chain producing cells to mutate to low secretors or to cells producing abnormal light chains which are catabolized rapidly. The clinical data from our patients do not indicate a more pessimistic prognosis in non- or low-secretory myeloma, than in other cases of multiple myeloma.
|
|
