SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:0028 0836 OR L773:1476 4687 "

Sökning: L773:0028 0836 OR L773:1476 4687

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1001.
  • Rorsman, Patrik, et al. (författare)
  • Cell biology. Glutamate primes the pump
  • 1999
  • Ingår i: Nature. - Nature Publishing Group. - 0028-0836. ; 402:6762, s. 595-596
  • Tidskriftsartikel (refereegranskat)
  •  
1002.
  •  
1003.
  • Rossi, Derrick J, et al. (författare)
  • Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
  • 2007
  • Ingår i: Nature. - Nature Publishing Group. - 0028-0836. ; 447:7145, s. 725-729
  • Tidskriftsartikel (refereegranskat)abstract
    • A diminished capacity to maintain tissue homeostasis is a central physiological characteristic of ageing. As stem cells regulate tissue homeostasis, depletion of stem cell reserves and/or diminished stem cell function have been postulated to contribute to ageing. It has further been suggested that accumulated DNA damage could be a principal mechanism underlying age-dependent stem cell decline. We have tested these hypotheses by examining haematopoietic stem cell reserves and function with age in mice deficient in several genomic maintenance pathways including nucleotide excision repair, telomere maintenance and non-homologous end-joining. Here we show that although deficiencies in these pathways did not deplete stem cell reserves with age, stem cell functional capacity was severely affected under conditions of stress, leading to loss of reconstitution and proliferative potential, diminished self-renewal, increased apoptosis and, ultimately, functional exhaustion. Moreover, we provide evidence that endogenous DNA damage accumulates with age in wild-type stem cells. These data are consistent with DNA damage accrual being a physiological mechanism of stem cell ageing that may contribute to the diminished capacity of aged tissues to return to homeostasis after exposure to acute stress or injury.
  •  
1004.
  • Rowe, Helen M., et al. (författare)
  • KAP1 controls endogenous retroviruses in embryonic stem cells
  • 2010
  • Ingår i: Nature. - Nature Publishing Group. - 0028-0836. ; 463, s. 40-237
  • Tidskriftsartikel (refereegranskat)abstract
    • More than forty per cent of the mammalian genome is derived from retroelements, of which about one-quarter are endogenous retroviruses (ERVs). Some are still active, notably in mice the highly polymorphic early transposon (ETn)/MusD and intracisternal A-type particles (IAP). ERVs are transcriptionally silenced during early embryogenesis by histone and DNA methylation (and reviewed in ref. 7), although the initiators of this process, which is essential to protect genome integrity, remain largely unknown. KAP1 (KRAB-associated protein 1, also known as tripartite motif-containing protein 28, TRIM28) represses genes by recruiting the histone methyltransferase SETDB1, heterochromatin protein 1 (HP1) and the NuRD histone deacetylase complex, but few of its physiological targets are known. Two lines of evidence suggest that KAP1-mediated repression could contribute to the control of ERVs: first, KAP1 can trigger permanent gene silencing during early embryogenesis, and second, a KAP1 complex silences the retrovirus murine leukaemia virus in embryonic cells. Consistent with this hypothesis, here we show that KAP1 deletion leads to a marked upregulation of a range of ERVs, in particular IAP elements, in mouse embryonic stem (ES) cells and in early embryos. We further demonstrate that KAP1 acts synergistically with DNA methylation to silence IAP elements, and that it is enriched at the 5' untranslated region (5'UTR) of IAP genomes, where KAP1 deletion leads to the loss of histone 3 lysine 9 trimethylation (H3K9me3), a hallmark of KAP1-mediated repression. Correspondingly, IAP 5'UTR sequences can impose in cis KAP1-dependent repression on a heterologous promoter in ES cells. Our results establish that KAP1 controls endogenous retroelements during early embryonic development.
  •  
1005.
  • Rowland, L, et al. (författare)
  • Death from drought in tropical forests is triggered by hydraulics not carbon starvation.
  • 2015
  • Ingår i: Nature. - Nature Publishing Group. - 0028-0836. ; 528:7580, s. 119-122
  • Tidskriftsartikel (refereegranskat)abstract
    • Drought threatens tropical rainforests over seasonal to decadal timescales, but the drivers of tree mortality following drought remain poorly understood. It has been suggested that reduced availability of non-structural carbohydrates (NSC) critically increases mortality risk through insufficient carbon supply to metabolism ('carbon starvation'). However, little is known about how NSC stores are affected by drought, especially over the long term, and whether they are more important than hydraulic processes in determining drought-induced mortality. Using data from the world's longest-running experimental drought study in tropical rainforest (in the Brazilian Amazon), we test whether carbon starvation or deterioration of the water-conducting pathways from soil to leaf trigger tree mortality. Biomass loss from mortality in the experimentally droughted forest increased substantially after >10 years of reduced soil moisture availability. The mortality signal was dominated by the death of large trees, which were at a much greater risk of hydraulic deterioration than smaller trees. However, we find no evidence that the droughted trees suffered carbon starvation, as their NSC concentrations were similar to those of non-droughted trees, and growth rates did not decline in either living or dying trees. Our results indicate that hydraulics, rather than carbon starvation, triggers tree death from drought in tropical rainforest.
  •  
1006.
  • Royant, A, et al. (författare)
  • Helix deformation is coupled to vectorial proton transport in the photocycle of bacteriorhodopsin
  • 2000
  • Ingår i: NATURE. - MACMILLAN PUBLISHERS LTD. - 0028-0836. ; 406:6796, s. 645-648
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>A wide variety of mechanisms are used to generate a protonmotive potential across cell membranes, a function lying at the heart of bioenergetics. Bacteriorhodopsin, the simplest known proton pump(1), provides a paradigm for understanding this process. Her</p>
  •  
1007.
  •  
1008.
  • Rundlöf, Maj, et al. (författare)
  • Seed coating with a neonicotinoid insecticide negatively affects wild bees.
  • 2015
  • Ingår i: Nature. - Nature Publishing Group. - 0028-0836. ; 521:7550, s. 77-162
  • Tidskriftsartikel (refereegranskat)abstract
    • Understanding the effects of neonicotinoid insecticides on bees is vital because of reported declines in bee diversity and distribution and the crucial role bees have as pollinators in ecosystems and agriculture. Neonicotinoids are suspected to pose an unacceptable risk to bees, partly because of their systemic uptake in plants, and the European Union has therefore introduced a moratorium on three neonicotinoids as seed coatings in flowering crops that attract bees. The moratorium has been criticized for being based on weak evidence, particularly because effects have mostly been measured on bees that have been artificially fed neonicotinoids. Thus, the key question is how neonicotinoids influence bees, and wild bees in particular, in real-world agricultural landscapes. Here we show that a commonly used insecticide seed coating in a flowering crop can have serious consequences for wild bees. In a study with replicated and matched landscapes, we found that seed coating with Elado, an insecticide containing a combination of the neonicotinoid clothianidin and the non-systemic pyrethroid β-cyfluthrin, applied to oilseed rape seeds, reduced wild bee density, solitary bee nesting, and bumblebee colony growth and reproduction under field conditions. Hence, such insecticidal use can pose a substantial risk to wild bees in agricultural landscapes, and the contribution of pesticides to the global decline of wild bees may have been underestimated. The lack of a significant response in honeybee colonies suggests that reported pesticide effects on honeybees cannot always be extrapolated to wild bees.
  •  
1009.
  • Ryan, K. K., et al. (författare)
  • FXR is a molecular target for the effects of vertical sleeve gastrectomy
  • 2014
  • Ingår i: Nature. - 0028-0836. ; 509:7499, s. 183-188
  • Tidskriftsartikel (refereegranskat)abstract
    • Bariatric surgical procedures, such as vertical sleeve gastrectomy (VSG), are at present the most effective therapy for the treatment of obesity, and are associated with considerable improvements in co-morbidities, including type-2 diabetes mellitus. The underlying molecular mechanisms contributing to these benefits remain largely undetermined, despite offering the potential to reveal new targets for therapeutic intervention. Substantial changes in circulating total bile acids are known to occur after VSG. Moreover, bile acids are known to regulate metabolism by binding to the nuclear receptor FXR (farsenoid-X receptor, also known as NR1H4). We therefore examined the results of VSG surgery applied to mice with diet-induced obesity and targeted genetic disruption of FXR. Here we demonstrate that the therapeutic value of VSG does not result from mechanical restriction imposed by a smaller stomach. Rather, VSG is associated with increased circulating bile acids, and associated changes to gut microbial communities. Moreover, in the absence of FXR, the ability of VSG to reduce body weight and improve glucose tolerance is substantially reduced. These results point to bile acids and FXR signalling as an important molecular underpinning for the beneficial effects of this weight-loss surgery.
  •  
1010.
  •  
Skapa referenser, mejla, bekava och länka
Åtkomst
fritt online (59)
Typ av publikation
tidskriftsartikel (1128)
forskningsöversikt (11)
annan publikation (10)
recension (9)
Typ av innehåll
refereegranskat (1025)
övrigt vetenskapligt (254)
populärvet., debatt m.m. (9)
Författare/redaktör
Collins, Francis S. (23)
Chasman, Daniel I., (21)
Ahlberg, Per E., (20)
Thorleifsson, Gudmar (20)
Hofman, Albert (19)
Harris, Tamara B. (19)
visa fler...
Gudnason, Vilmundur (18)
Ridker, Paul M., (18)
Mangino, Massimo (18)
Gieger, Christian (18)
Esko, Tonu (18)
Jackson, Anne U. (17)
Prokopenko, Inga (17)
Hayward, Caroline (17)
Caulfield, Mark J. (17)
Lindblad-Toh, Kersti ... (16)
Melander, Olle, (16)
Uitterlinden, Andre ... (16)
Salomaa, Veikko (16)
Lander, Eric S. (16)
Luan, Jian'an (16)
Hicks, Andrew A. (16)
Stringham, Heather M ... (16)
Amin, Najaf (15)
Teumer, Alexander (15)
Montgomery, Grant W. (15)
Wareham, Nicholas J (15)
Rose, Lynda M (15)
Feitosa, Mary F. (15)
Zhao, Jing Hua (15)
Perry, John R. B. (15)
Van Duijn, Cornelia ... (14)
Mohlke, Karen L (14)
Andersson, Leif, (14)
Wood, Andrew R. (14)
Sanna, Serena (14)
Campbell, Harry (14)
McArdle, Wendy L. (14)
Bergman, Richard N. (14)
Groop, Leif, (13)
Kuusisto, Johanna, (13)
McCarthy, Mark I (13)
Langenberg, Claudia (13)
Kaprio, Jaakko (13)
Samani, Nilesh J. (13)
Jarvelin, Marjo-Riit ... (13)
Hattersley, Andrew T (13)
Estrada, Karol (13)
Vedantam, Sailaja (13)
Ohlsson, Claes (13)
visa färre...
Lärosäte
Karolinska Institutet (242)
Uppsala universitet (240)
Lunds universitet (186)
Stockholms universitet (136)
Göteborgs universitet (86)
Umeå universitet (75)
visa fler...
Kungliga Tekniska Högskolan (54)
Chalmers tekniska högskola (45)
Linköpings universitet (43)
Sveriges Lantbruksuniversitet (43)
Linnéuniversitetet (13)
RISE (9)
Luleå tekniska universitet (7)
Örebro universitet (5)
Högskolan i Halmstad (4)
Mittuniversitetet (3)
Naturhistoriska riksmuseet (3)
Högskolan i Jönköping (2)
Södertörns högskola (2)
Högskolan i Skövde (2)
Högskolan Dalarna (2)
Mälardalens högskola (1)
Högskolan i Gävle (1)
visa färre...
Språk
Engelska (1153)
Odefinierat språk (3)
Svenska (1)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (562)
Medicin och hälsovetenskap (205)
Samhällsvetenskap (36)
Teknik (34)
Lantbruksvetenskap (28)
Humaniora (17)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy