| 61. |
- Rydén, Stefan, et al.
(författare)
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A scintillation camera technique for measurements of the reticuloendothelial function -Comparison of different methods for measuring RES function
- 1982
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Ingår i: European Journal Of Nuclear Medicine. - 0340-6997. ; 7, s. 16-21
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Tidskriftsartikel (refereegranskat)abstract
- A highly standardized 99mTc-sulphur colloid was used to evaluate reticuloendothelial system (RES)-function in the normal rat and after RE blockade by gelatin (Haemaccel). Activity distribution in the animals was measured with a scintillation camera technique. Total uptake of activity in the liver was estimated. From the time-activity curves over the liver, the phagocytic index (kphag) was evaluated. Estimation of the uptake rate of the labelled colloid into the liver and into other parts of the RES was also performed using a twocompartment model. Different methods of evaluation of RE function were compared. It was shown that for a proper estimation of the RE function, the whole uptake curve must be considered. Gelatin (Haemaccel) significantly reduced the total colloid uptake by the liver. The colloid uptake rate into the liver was also significantly reduced. Liver specimens after colloid injection were examined by light and electron microscopy showing vacuolation of hepatocytes and sinusoidal cells probably due to pinocytosis. The technique described enables functional studies of the RES. It has the advantage of noninvasive registrations and is based on the same technical facilities as used for routine liver scintigraphy.
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| 62. |
- Rydh, Anders, et al.
(författare)
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Serum amyloid P component scintigraphy in familial amyloid polyneuropathy : regression of visceral amyloid following liver transplantation.
- 1998
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Ingår i: European Journal of Nuclear Medicine. - 0340-6997 .- 1432-105X. ; 25:7, s. 709-713
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Tidskriftsartikel (refereegranskat)abstract
- Familial amyloid polyneuropathy (FAP) associated with transthyretin (TTR) mutations is the commonest type of hereditary amyloidosis. Plasma TTR is produced almost exclusively in the liver and orthotopic liver transplantation is the only available treatment, although the clinical outcome varies. Serum amyloid P component (SAP) scintigraphy is a method for identifying and quantitatively monitoring amyloid deposits in vivo, but it has not previously been used to study the outcome of visceral amyloid deposits in FAP following liver transplantation. Whole body scintigraphy following injection of iodine-123 labelled SAP was performed in 17 patients with FAP associated with TTR Met30 and in five asymptomatic gene carriers. Follow-up studies were performed in ten patients, eight of whom had undergone orthotopic liver transplantation 1-5 years beforehand. There was abnormal uptake of 123I-SAP in all FAP patients, including the kidneys in each case, the spleen in five cases and the adrenal glands in three cases. Renal amyloid deposits were also present in three of the asymptomatic carriers. Follow-up studies 1-5 years after liver transplantation showed that there had been substantial regression of the visceral amyloid deposits in two patients and modest improvement in three cases. The amyloid deposits were unchanged in two patients. In conclusion, 123I-SAP scintigraphy identified unsuspected visceral amyloid in each patient with FAP due to TTR Met30. The universal presence of renal amyloid probably underlies the high frequency of renal failure that occurs in FAP following liver transplantation. The variable capacity of patients to mobilise amyloid deposits following liver transplantation may contribute to their long-term clinical outcome.
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| 63. |
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| 64. |
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| 65. |
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| 66. |
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| 67. |
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| 68. |
- Strand, Sven Erik, et al.
(författare)
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The dual photopeak-area method applied to scintillation camera measurements of effective depth and activity of in vivo 123I-distributions
- 1977
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Ingår i: European Journal Of Nuclear Medicine. - 0340-6997. ; 2:2, s. 121-128
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Tidskriftsartikel (refereegranskat)abstract
- Attenuation curves and photopeak ratios of 159 keV and 28 keV phtons emitted in the decay of 123I have been studied using a scintillation camera equipped with an extra ADC for recording the pulse height distribution of the energy signal. Cavities of various sizes containing 123I-solution were placed at different depths in a water phantom in order to vary the effective depth, i.e., the thickness of attenuating material above the cavity plus the distance to the centre of activity in the cavity. The centre of activity varies with the distribution of activity in the cavity, size of cavity, and the effective attenuation coefficient derived from the attenuation curves. From the photopeak ratio an average effective depth is determined which can be used for calculating the attenuation correction factor. The dual photopeak ratio has been used in clinical evaluation of thyroid 123I uptake measurements where effective depths ranging from 21 to 43 mm were obtained for the activity in the thyroid. Applications of the photopeak ratio method for renography with 123I-hippuran and blood flow studies using 133Xe or 127Xe and studies with many other radionuclides are also discussed.
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| 69. |
- Sundberg, Åsa Liljegren, et al.
(författare)
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Treatment of cultured glioma cells with EGFR-TKI gefitinib (‘Iressa’, ZD1839) increases the uptake of astatinated EGF despite absence of gefitinib-mediated growth inhibition
- 2003
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Ingår i: European Journal of Nuclear Medicine. - : Springer Science and Business Media LLC. - 0340-6997 .- 1432-105X .- 1619-7070 .- 1619-7089. ; 30:5, s. 727-9
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Tidskriftsartikel (refereegranskat)abstract
- The EGFR-TKI (epidermal growth factor receptor tyrosine kinase inhibitor) gefitinib ("Iressa", ZD1839), a reversible growth inhibitor of EGFR-expressing tumour cells, has been shown to enhance the antitumour effect of ionising radiation, and also to increase the uptake of radioiodinated EGF. Thus, combination of gefitinib treatment and radionuclide targeting is an interesting option for therapy of brain tumours that are difficult to treat with conventional methods. The aim of this study was to evaluate how pre-treatment with gefitinib affects binding of astatinated EGF ((211)At-EGF) to cultured glioma U343 cells, which express high levels of EGFR. The growth of U343 cells in the presence of gefitinib was investigated, and it was found that gefitinib does not significantly inhibit the growth of these cells. Nevertheless, the uptake of (211)At-EGF in U343 cells was markedly increased (up to 3.5 times) in cells pre-treated with gefitinib (1 microM). This indicates that a combination of gefitinib treatment and radionuclide targeting to EGFR might be a useful therapeutic modality, even for patients who do not respond to treatment with gefitinib alone.
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| 70. |
- Thurfjell, L, et al.
(författare)
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Improved efficiency for MRI-SPET registration based on mutual information
- 2000
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Ingår i: EUROPEAN JOURNAL OF NUCLEAR MEDICINE. - 0340-6997. ; 27:7, s. 847-856
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Tidskriftsartikel (refereegranskat)abstract
- Mutual information has been proposed as a criterion for image registration. The criterion is calculated from a two-dimensional grey-scale histogram of the image pair being registered, In this paper we study how sparse sampling can be used to increase spee
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