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| 52. |
- Soda, T., et al.
(författare)
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International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic)
- 2020
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Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 270:7, s. 921-932
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Tidskriftsartikel (refereegranskat)abstract
- Recent genome-wide association studies have demonstrated that the genetic burden associated with depression correlates with depression severity. Therefore, conducting genetic studies of patients at the most severe end of the depressive disorder spectrum, those with treatment-resistant depression and who are prescribed electroconvulsive therapy (ECT), could lead to a better understanding of the genetic underpinnings of depression. Despite ECT being one of the most effective forms of treatment for severe depressive disorders, it is usually placed at the end of treatment algorithms of current guidelines. This is perhaps because ECT has controlled risk and logistical demands including use of general anaesthesia and muscle relaxants and side-effects such as short-term memory impairment. Better understanding of the genetics and biology of ECT response and of cognitive side-effects could lead to more personalized treatment decisions. To enhance the understanding of the genomics of severe depression and ECT response, researchers and ECT providers from around the world and from various depression or ECT networks, but not limited to, such as the Psychiatric Genomics Consortium, the Clinical Alliance and Research in ECT, and the National Network of Depression Centers have formed the Genetics of ECT International Consortium (Gen-ECT-ic). Gen-ECT-ic will organize the largest clinical and genetic collection to date to study the genomics of severe depressive disorders and response to ECT, aiming for 30,000 patients worldwide using a GWAS approach. At this stage it will be the largest genomic study on treatment response in depression. Retrospective data abstraction and prospective data collection will be facilitated by a uniform data collection approach that is flexible and will incorporate data from many clinical practices. Gen-ECT-ic invites all ECT providers and researchers to join its efforts.
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| 53. |
- Stralin, P, et al.
(författare)
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First episode psychosis: register-based study of comorbid psychiatric disorders and medications before and after
- 2021
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Ingår i: European archives of psychiatry and clinical neuroscience. - : Springer Science and Business Media LLC. - 1433-8491 .- 0940-1334. ; 271:2, s. 303-313
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Tidskriftsartikel (refereegranskat)abstract
- Comorbid psychiatric disorders are common in first episode psychosis. We investigated comorbid disorders before, at, and after a first hospital-treated psychosis in a naturalistic nation-wide cohort (n = 2091) with a first psychosis hospitalization between 2007 and 2011, and at ages between 16 and 25. Swedish population registers were used to identify the cohort and to collect data on diagnoses at hospitalizations and medications. The proportions of cases with hospitalizations or medications increased year by year before and decreased in the years after the first psychosis hospitalization. In the 2 years before, 30% had hospitalizations with other psychiatric diagnoses and 60% had psychiatric medications. At the first psychosis hospitalization, 46% had other comorbid psychiatric diagnoses or self-harm. In the 2 years before or at the first psychosis hospitalization, 17% had anxiety or stress disorders at hospitalizations, 12% depressive disorders, 5.4% manic or bipolar disorders, 8.6% personality disorders, 26% substance use disorders, and 15% neurodevelopmental disorders. 8.2% had hospitalizations for self-harm. At most, around 30% of the cases were estimated not to have had any comorbid psychiatric disorders before or at the first psychosis presentation. Early comorbid affective, anxiety or personality disorders or self-harm were associated with a worse outcome, as measured by new psychiatric hospitalizations. The outcome was worst for personality disorders with 73% re-hospitalizations within 1 year and for patients with self-harm with 70% re-hospitalizations. In conclusion, most cases with a first psychosis hospitalization had clinical presentations indicating comorbid psychiatric disorders. Cases with comorbidity had a higher risk for re-hospitalizations.
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| 54. |
- Sunnqvist, Charlotta, et al.
(författare)
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Suicide attempters :biological stressmarkers and adverse life events
- 2008
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Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - : EAPCN. - 0940-1334 .- 1433-8491. ; 258:8, s. 456-462
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Tidskriftsartikel (refereegranskat)abstract
- Risk factors for suicidal behaviour include adverse life events as well as biochemical parameters acting, e.g. within the hypothalamic–pituitary– adrenal axis and/or monoaminergic systems. The aim of the present investigation was to study stressful life events and biological stress markers among former psychiatric inpatients, who were followed up 12 years after an index suicide attempt. At the time of the index suicide attempt, and before treatment, cerebrospinal fluid (CSF) samples were taken, and 24 h (h) urine (U) was collected. 3-Methoxy-4-hydroxyphenylglycole (MHPG) in CSF and 24 h urinary samples of cortisol and noradrenaline/adrenaline (NA/A) were analysed. Data concerning stressful life events were collected retrospectively from all participants in the study through semi-structured interviews at follow-up. We found that patients who reported sexual abuse during childhood and adolescence had significantly higher levels of CSF-MHPG and U-NA/A, than those who had not. Low 24 h U-cortisol was associated with feelings of neglect during childhood and adolescence. In conclusion, this study has shown significant and discrepant biological stress-system findings in relation to some adverse life events.
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| 55. |
- Toro, P., et al.
(författare)
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Cholesterol in mild cognitive impairment and Alzheimer's disease in a birth cohort over 14 years
- 2014
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Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - : Dr. Dietrich Steinkopff Verlag GmbH and Co. KG. - 0940-1334 .- 1433-8491. ; 264:6, s. 485-492
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Tidskriftsartikel (refereegranskat)abstract
- Animal epidemiological and clinical studies suggest that cholesterol is a risk factor for Alzheimer's disease (AD). Nevertheless, the relation of cholesterol to mild cognitive impairment (MCI), influence of APOE genotype and its changes in lifespan is controversial. We investigated the potential impact of plasma total cholesterol (TC) on development of MCI and AD in the interdisciplinary longitudinal study on adult development and aging, a representative birth cohort (born 1930-1932), examined in 1993/1994 (VT1), 1997/1998 (VT2), and 2005/2007 (VT3). Of 500 participants at baseline, 381 survived and were examined at VT3. After exclusion of participants with lifetime prevalence of major psychiatric diseases or mild cognitive disorder due to a medical condition, 222 participants were included in the analysis. At VT3, 82 participants had MCI, 22 participants had AD, and 118 were in good health. Participants with MCI and AD at VT3 evidenced higher TC levels at VT1 than those who were healthy. Higher TC levels at baseline were associated with an increased risk for cognitive disorders at VT3 (highest vs. lowest quartile: OR 2.64, 95 % CI 1.12-6.23, p < 0.05). Over the 14 year follow-up, TC levels declined in those with MCI and AD, but remained stable in those who remained healthy. These findings were not modified by APOE genotype or use of cholesterol-lowering medications. Our findings demonstrate that higher TC levels are observed long before the clinical manifestation of MCI and AD in patients without psychiatric or somatic comorbidities and are independent of APOE genotype. © 2013 Springer-Verlag.
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| 56. |
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| 57. |
- Waern, Margda, 1955, et al.
(författare)
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Suicidal ideation in a female population sample. Relationship with depression, anxiety disorder and alcohol dependence/abuse.
- 2002
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Ingår i: European archives of psychiatry and clinical neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 252:2, s. 81-5
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The aim was to analyse the association between three psychiatric disorders (anxiety disorder, depression and alcohol dependence/abuse) and past year suicidal ideation in women. METHOD: As part of the longitudinal population-based study "Women and Alcohol in Göteborg", face-to-face interviews were administered to a stratified sample of 25-65 year old women (n = 313). Past year and lifetime diagnoses of depression, anxiety disorder and alcohol dependence/abuse were made according to DSM-III-R. Past year suicidal feelings were rated according to Paykel et al. RESULTS: The weighted one-year prevalence of suicidal thoughts was 6.6%. Such thoughts were acknowledged by 24.2% of the women with a depressive disorder, 20% of the women with an anxiety disorder and 22.7% of those with alcohol dependence/abuse (ADA) during the past year. Depressive disorder and ADA were associated with suicidal thoughts in the univariate analysis. Such an association could not be shown for anxiety disorder. When all three disorders were entered into a logistic regression model, only depressive disorder remained associated with past year suicidal ideation. One third of the women who reported past year suicidal thoughts did not fulfil criteria for a DSM-III-R Axis I disorder during this time period. IMPLICATIONS: Our results underline the need for assessment of suicidality even in women with subsyndromal states.
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